ID SU6H_HUMAN STANDARD; PRT; 1726 AA. AC Q7KZ85; Q15737; Q6GMQ4; Q7KYW9; Q7LDK4; Q8N526; Q92775; Q96AH3; AC Q9BTH9; Q9BTI2; DT 25-OCT-2004 (Rel. 45, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 25-OCT-2004 (Rel. 45, Last annotation update) DE Suppressor of Ty 6 homolog protein (Chromatin structural protein). GN Name=SUPT6H; Synonyms=KIAA0162, SPTH6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM 1). RX MEDLINE=96374824; PubMed=8786132; DOI=10.1006/geno.1996.0294; RA Chiang P.-W., Wang S., Smithivas P., Song W.-J., Ramamoorthy S., RA Hillman J., Puett S., Van Keuren M.L., Crombez E., Kumar A., RA Glover T.W., Miller D.E., Tsai C.-H., Blackburn C.C., Chen X.-N., RA Sun Z., Cheng J.-F., Korenberg J.R., Kurnit D.M.; RT "Identification and analysis of the human and murine putative RT chromatin structure regulator SUPT6H and Supt6h."; RL Genomics 34:328-333(1996). RN [2] RP SEQUENCE FROM N.A. (ISOFORM 1). RC TISSUE=Bone marrow; RX MEDLINE=96281124; PubMed=8724849; RA Nagase T., Seki N., Ishikawa K.-I., Tanaka A., Nomura N.; RT "Prediction of the coding sequences of unidentified human genes. V. RT The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by RT analysis of cDNA clones from human cell line KG-1."; RL DNA Res. 3:17-24(1996). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS 1; 2 AND 3). RC TISSUE=Cervix, Lung, Melanoma, Placenta, and Testis; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP SEQUENCE OF 1460-1726 FROM N.A. (ISOFORM 1/2). RC TISSUE=Brain; RA Yu W., Gibbs R.A.; RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May be a mediator of differentiation and development CC through the establishment and/or maintenance of chromatin CC structure. CC -!- SUBCELLULAR LOCATION: Nuclear (Probable). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q7KZ85-1; Sequence=Displayed; CC Name=2; CC IsoId=Q7KZ85-2; Sequence=VSP_011505, VSP_011506; CC Name=3; CC IsoId=Q7KZ85-3; Sequence=VSP_011507; CC -!- TISSUE SPECIFICITY: Ubiquitously expressed. CC -!- SIMILARITY: Contains 1 S1 motif domain. CC -!- SIMILARITY: Contains 1 SH2 domain. CC -!- CAUTION: Ref.1 (AAB18949) sequence differs from that shown due to CC a frameshift in position 988. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U38623; AAC99996.1; -. DR EMBL; U38658; AAB18949.1; ALT_FRAME. DR EMBL; U46691; AAC50821.1; ALT_INIT. DR EMBL; D79984; BAA11479.2; ALT_INIT. DR EMBL; BC003692; AAH03692.1; -. DR EMBL; BC003696; AAH03696.1; -. DR EMBL; BC017105; AAH17105.1; -. DR EMBL; BC033074; AAH33074.1; ALT_INIT. DR EMBL; BC073963; AAH73963.1; -. DR EMBL; AF070532; AAC28631.1; -. DR Genew; HGNC:11470; SUPT6H. DR MIM; 601333; -. DR GO; GO:0005634; C:nucleus; TAS. DR GO; GO:0003700; F:transcription factor activity; TAS. DR GO; GO:0006333; P:chromatin assembly/disassembly; TAS. DR GO; GO:0006338; P:chromatin remodeling; NAS. DR GO; GO:0006357; P:regulation of transcription from Pol II pro...; TAS. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; NAS. DR InterPro; IPR008994; Nucleic_acid_OB. DR InterPro; IPR003029; S1. DR InterPro; IPR000980; SH2. DR InterPro; IPR006641; YqgFc. DR Pfam; PF00575; S1; 1. DR Pfam; PF00017; SH2; 1. DR SMART; SM00316; S1; 1. DR SMART; SM00252; SH2; 1. DR SMART; SM00732; YqgFc; 1. DR PROSITE; PS50126; S1; 1. DR PROSITE; PS50001; SH2; 1. KW Alternative splicing; Coiled coil; Nuclear protein. FT DOMAIN 1213 1282 S1 motif. FT DOMAIN 1325 1431 SH2. FT DOMAIN 6 250 Asp/Glu-rich. FT DOMAIN 478 498 Coiled coil (Potential). FT DOMAIN 1525 1528 Poly-Ser. FT DOMAIN 1654 1657 Poly-Ser. FT VARSPLIC 1 1181 Missing (in isoform 2). FT /FTId=VSP_011505. FT VARSPLIC 1182 1211 ESYDQAIRNDETGLWQCPFCQQDNFPELSE -> MPSRGTR FT PEDSSVLIPTDNSTPHKEDLSSK (in isoform 2). FT /FTId=VSP_011506. FT VARSPLIC 617 1616 Missing (in isoform 3). FT /FTId=VSP_011507. FT CONFLICT 61 73 DDDEDEGEEDEGS -> ATAPGHPKLSEGR (in Ref. FT 1; AAC50821). FT CONFLICT 100 109 DFDLIEENLG -> LEDDDFLLNE (in Ref. 3; FT AAH33074). FT CONFLICT 988 994 YVCGLGP -> VCLWPGT (in Ref. 1). FT CONFLICT 1545 1545 L -> P (in Ref. 3; AAH17105). FT CONFLICT 1627 1627 S -> I (in Ref. 3; AAH17105). SQ SEQUENCE 1726 AA; 199071 MW; F7EB22FA669EB030 CRC64; MSDFVESEAE ESEEEYNDEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE QGNLKGFIND DDDEDEGEED EGSDSGDSED DVGHKKRKRT SFDDRLEDDD FDLIEENLGV KVKRGQKYRR VKKMSDDEDD DEEEYGKEEH EKEAIAEEIF QDGEGEEGQE AMEAPMAPPE EEEEDDEESD IDDFIVDDDG QPLKKPKWRK KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEEY EYEDDEAEGE IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL RSIPVKGAED DELEEEADWI YRNAFATPTI SLQESCDYLD RGQPASSFSR KGPSTIQKIK EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD EKWTQLRIRK ENLTRLFEKM QAYQYEQISA DPDKPLADGI RALDTTDMER LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN AAKASRKKLK RVREEGDEEG EGDEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG LTPEQFGENL RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD DQFLKICLAE DEGLLTTDIS IDLKGVEGYG NDQTYFEEIK QFYYRDEFSH QVQEWNRQRT MAIERALQQF LYVQMAKELK NKLLAEAKEY VIKACSRKLY NWLRVAPYRP DQQVEEDDDF MDENQGKGIR VLGIAFSSAR DHPVFCALVN GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL LNKKPHVVTV AGENRDAQML IEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV KEELLNALYC EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL LKILKQNNTR LESRTQLVTM CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI EVLDGSRVHP ETYEWARKMA VDALEYDESA EDANPAGALE EILENPERLK DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA YRSPNTEEIF NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV KRPEERVKVG MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY YDFDAEAADH KQEEDMKRKQ QRTTYIKRVI AHPSFHNINF KQAEKMMETM DQGDVIIRPS SKGENHLTVT WKVSDGIYQH VDVREEGKEN AFSLGATLWI NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR KKLEELLIKT KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI FPTVNGLFRW FKDHYQDPVP GITPSSSSRT RTPASINATP ANINLADLTR AVNALPQNMT SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA YHVFPTPAQQ PVATPLMTPS YSYTTPSQPI TTPQYHQLQA STTPQSAQAQ PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ WLQEKEAERR KQKQRLTPRP SPSPMIESTP MSIAGDATPL LDEMDR //