ID Q7KWJ5_PLAF7 Unreviewed; 504 AA. AC Q7KWJ5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 07-OCT-2020, entry version 128. DE SubName: Full=Hexose transporter {ECO:0000313|EMBL:CZT98059.1}; GN ORFNames=PF3D7_0204700 {ECO:0000313|EMBL:CZT98059.1}; OS Plasmodium falciparum (isolate 3D7). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98059.1, ECO:0000313|Proteomes:UP000001450}; RN [1] {ECO:0000313|EMBL:CZT98059.1, ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=9804551; DOI=10.1126/science.282.5391.1126; RA Gardner M.J., Tettelin H., Carucci D.J., Cummings L.M., Aravind L., RA Koonin E.V., Shallom S., Mason T., Yu K., Fujii C., Pederson J., Shen K., RA Jing J., Aston C., Lai Z., Schwartz D.C., Pertea M., Salzberg S., Zhou L., RA Sutton G.G., Clayton R., White O., Smith H.O., Fraser C.M., Adams M.D., RA Venter J.C., Hoffman S.L.; RT "Chromosome 2 sequence of the human malaria parasite Plasmodium RT falciparum."; RL Science 282:1126-1132(1998). RN [2] {ECO:0000313|EMBL:CZT98059.1, ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=12368864; DOI=10.1038/nature01097; RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S., RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.; RT "Genome sequence of the human malaria parasite Plasmodium falciparum."; RL Nature 419:498-511(2002). CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar CC transporter (TC 2.A.1.1) family. {ECO:0000256|RuleBase:RU003346}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LN999943; CZT98059.1; -; Genomic_DNA. DR RefSeq; XP_001349558.1; XM_001349522.1. DR SMR; Q7KWJ5; -. DR SwissPalm; Q7KWJ5; -. DR PRIDE; Q7KWJ5; -. DR EnsemblProtists; CZT98059; CZT98059; PF3D7_0204700. DR GeneDB; PF3D7_0204700.1:pep; -. DR GeneID; 812640; -. DR KEGG; pfa:PF3D7_0204700; -. DR EuPathDB; PlasmoDB:PF3D7_0204700; -. DR HOGENOM; CLU_001265_30_5_1; -. DR OMA; SCHEQEM; -. DR Reactome; R-PFA-189200; Cellular hexose transport. DR Reactome; R-PFA-196836; Vitamin C (ascorbate) metabolism. DR Reactome; R-PFA-422356; Regulation of insulin secretion. DR Reactome; R-PFA-5653890; Lactose synthesis. DR Reactome; R-PFA-6798695; Neutrophil degranulation. DR Reactome; R-PFA-8981373; Intestinal hexose absorption. DR Proteomes; UP000001450; Chromosome 2. DR GO; GO:0005887; C:integral component of plasma membrane; IDA:GeneDB. DR GO; GO:0005353; F:fructose transmembrane transporter activity; IDA:GeneDB. DR GO; GO:0005355; F:glucose transmembrane transporter activity; IDA:GeneDB. DR GO; GO:0015149; F:hexose transmembrane transporter activity; IDA:GeneDB. DR GO; GO:0008645; P:hexose transmembrane transport; IDA:GeneDB. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR005828; MFS_sugar_transport-like. DR InterPro; IPR036259; MFS_trans_sf. DR InterPro; IPR003663; Sugar/inositol_transpt. DR InterPro; IPR005829; Sugar_transporter_CS. DR Pfam; PF00083; Sugar_tr; 1. DR PRINTS; PR00171; SUGRTRNSPORT. DR SUPFAM; SSF103473; SSF103473; 1. DR TIGRFAMs; TIGR00879; SP; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000001450}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}; KW Transport {ECO:0000256|RuleBase:RU003346}. FT DOMAIN 29..480 FT /note="MFS" FT /evidence="ECO:0000259|PROSITE:PS50850" SQ SEQUENCE 504 AA; 56417 MW; 79AE4CB7D514FA58 CRC64; MTKSSKDICS ENEGKKNGKS GFFSTSFKYV LSACIASFIF GYQVSVLNTI KNFIVVEFEW CKGEKDRLNC SNNTIQSSFL LASVFIGAVL GCGFSGYLVQ FGRRLSLLII YNFFFLVSIL TSITHHFHTI LFARLLSGFG IGLVTVSVPM YISEMTHKDK KGAYGVMHQL FITFGIFVAV MLGLAMGEGP KADSTEPLTS FAKLWWRLMF LFPSVISLIG ILALVVFFKE ETPYFLFEKG RIEESKNILK KIYETDNVDE PLNAIKEAVE QNESAKKNSL SLLSALKIPS YRYVIILGCL LSGLQQFTGI NVLVSNSNEL YKEFLDSHLI TILSVVMTAV NFLMTFPAIY IVEKLGRKTL LLWGCVGVLV AYLPTAIANE INRNSNFVKI LSIVATFVMI ISFAVSYGPV LWIYLHEMFP SEIKDSAASL ASLVNWVCAI IVVFPSDIII KKSPSILFIV FSVMSILTFF FIFFFIKETK GGEIGTSPYI TMEERQKHMT KSVV //