ID Q7KVT3_DROME Unreviewed; 1367 AA. AC Q7KVT3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 16-JAN-2019, entry version 145. DE SubName: Full=Stardust, isoform E {ECO:0000313|EMBL:AAS65284.1}; DE EC=2.7.4.8 {ECO:0000313|EMBL:AAS65284.1}; GN Name=sdt {ECO:0000313|EMBL:AAS65284.1, GN ECO:0000313|FlyBase:FBgn0261873}; GN Synonyms=anon-EST:fe2E6 {ECO:0000313|EMBL:AAS65284.1}, BP1063 GN {ECO:0000313|EMBL:AAS65284.1}, CG12657 {ECO:0000313|EMBL:AAS65284.1}, GN CG12658 {ECO:0000313|EMBL:AAS65284.1}, CG15339 GN {ECO:0000313|EMBL:AAS65284.1}, CG15340 {ECO:0000313|EMBL:AAS65284.1}, GN CG15341 {ECO:0000313|EMBL:AAS65284.1}, CG15342 GN {ECO:0000313|EMBL:AAS65284.1}, CG1617 {ECO:0000313|EMBL:AAS65284.1}, GN cGUK1 {ECO:0000313|EMBL:AAS65284.1}, cMAGUK1 GN {ECO:0000313|EMBL:AAS65284.1}, Dmel\CG32717 GN {ECO:0000313|EMBL:AAS65284.1}, l(1)7Ef {ECO:0000313|EMBL:AAS65284.1}, GN pal1 {ECO:0000313|EMBL:AAS65284.1}, PALS1 GN {ECO:0000313|EMBL:AAS65284.1}, Pals1 {ECO:0000313|EMBL:AAS65284.1}, GN Sdt {ECO:0000313|EMBL:AAS65284.1}, Std {ECO:0000313|EMBL:AAS65284.1}, GN std {ECO:0000313|EMBL:AAS65284.1}; GN ORFNames=CG32717 {ECO:0000313|EMBL:AAS65284.1, GN ECO:0000313|FlyBase:FBgn0261873}, Dmel_CG32717 GN {ECO:0000313|EMBL:AAS65284.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [8] {ECO:0000313|EMBL:AAS65284.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). CC -!- SIMILARITY: Belongs to the MAGUK family. CC {ECO:0000256|SAAS:SAAS00914726}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAS65284.1; -; Genomic_DNA. DR RefSeq; NP_996376.1; NM_206653.3. DR UniGene; Dm.17605; -. DR ProteinModelPortal; Q7KVT3; -. DR SMR; Q7KVT3; -. DR PRIDE; Q7KVT3; -. DR EnsemblMetazoa; FBtr0089974; FBpp0088912; FBgn0261873. DR GeneID; 44861; -. DR UCSC; CG32717-RE; d. melanogaster. DR CTD; 44861; -. DR FlyBase; FBgn0261873; sdt. DR eggNOG; KOG0609; Eukaryota. DR eggNOG; COG0194; LUCA. DR GeneTree; ENSGT00940000156087; -. DR SignaLink; Q7KVT3; -. DR ChiTaRS; sdt; fly. DR GenomeRNAi; 44861; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0261873; Expressed in 35 organ(s), highest expression level in head. DR ExpressionAtlas; Q7KVT3; baseline and differential. DR GO; GO:0005912; C:adherens junction; IDA:FlyBase. DR GO; GO:0045179; C:apical cortex; IDA:FlyBase. DR GO; GO:0016324; C:apical plasma membrane; IDA:FlyBase. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:FlyBase. DR GO; GO:0005918; C:septate junction; TAS:FlyBase. DR GO; GO:0035003; C:subapical complex; IPI:FlyBase. DR GO; GO:0004385; F:guanylate kinase activity; ISS:FlyBase. DR GO; GO:0045176; P:apical protein localization; IMP:FlyBase. DR GO; GO:0007043; P:cell-cell junction assembly; NAS:FlyBase. DR GO; GO:0040003; P:chitin-based cuticle development; IMP:FlyBase. DR GO; GO:0007163; P:establishment or maintenance of cell polarity; NAS:FlyBase. DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:FlyBase. DR GO; GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:FlyBase. DR GO; GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase. DR GO; GO:0002009; P:morphogenesis of an epithelium; TAS:FlyBase. DR GO; GO:0042461; P:photoreceptor cell development; IMP:FlyBase. DR GO; GO:0045186; P:zonula adherens assembly; IMP:FlyBase. DR CDD; cd12036; SH3_MPP5; 1. DR InterPro; IPR008145; GK/Ca_channel_bsu. DR InterPro; IPR008144; Guanylate_kin-like_dom. DR InterPro; IPR020590; Guanylate_kinase_CS. DR InterPro; IPR014775; L27_C. DR InterPro; IPR004172; L27_dom. DR InterPro; IPR035601; MPP5_SH3. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF00625; Guanylate_kin; 1. DR Pfam; PF02828; L27; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF07653; SH3_2; 1. DR SMART; SM00072; GuKc; 1. DR SMART; SM00228; PDZ; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR SUPFAM; SSF50156; SSF50156; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1. DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1. DR PROSITE; PS51022; L27; 1. DR PROSITE; PS50106; PDZ; 1. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q7KVT3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192, KW ECO:0000256|SAAS:SAAS00071823}; KW Transferase {ECO:0000313|EMBL:AAS65284.1}. FT DOMAIN 762 818 L27. {ECO:0000259|PROSITE:PS51022}. FT DOMAIN 911 990 PDZ. {ECO:0000259|PROSITE:PS50106}. FT DOMAIN 1016 1087 SH3. {ECO:0000259|PROSITE:PS50002}. FT DOMAIN 1166 1346 Guanylate kinase-like. FT {ECO:0000259|PROSITE:PS50052}. FT COILED 183 206 {ECO:0000256|SAM:Coils}. FT COILED 622 642 {ECO:0000256|SAM:Coils}. FT COILED 1331 1351 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1367 AA; 148311 MW; 1D7E0610B05DF6EE CRC64; MRILKQWNRR RSGSSIVVLD GDDLKPCLPD DYISGQHHLN HQQQLQLQQQ LQQQHPLQQQ HYRTHSGDIR EIDQEMLTML SVNQDNGPHR EMAVDCPDTF IARNKTPPRY PPPRPPQKHK KSTNTTTTTT ITALTNNDHA NKMLIVAYHS SHQHEQLQQQ HPSKTSTTTT TIALDVATQN LYNQKQQNKL EQIENYENCL QSERNEQHEQ QFEQQKQHQA TTAMAATQVA QQQTPSHKLQ ATLSSDPNGN SNSNNNSHIV GISSSSSSNN SSITDDFLCV VDGLYQGRKD TASPSSSAFD EVMSKHTLDS FGSIAYRHLH QQHQATSNGN SSSNTSNTNS NTNSNTNSNS NTNGNTSNNT AVSTKTATVT KTGVSSSNSN SNSLNSSNSS MHTSSSSSGH SSNIASATSS SSATSSSTVP DDLSLAPPGY EVSQQQQQQH LVATPVTMLL PPMAKHRELP VDVPDSFIEM VKTTPRYPPP AHLSSRGSLL SNGSASTAHT TLSSMGVAPS PVTATAAAAA SASAACATTA VAAAAVSGVA DGDARRVADE LNGNAKPVPP PRDHLRVEKD GRLVNCSPAP QLPDRRAPGN ASSGSSGATT HPLQHQQIAQ IVEPTLEQLD SIKKYQEQLR RRREEEERIA QQNEFLRNSL RGSRKLKALQ DTATPGKAVA QQQQQATLAT QVVGVENEAY LPDEDQPQAE QIDGYGELIA ALTRLQNQLS KSGLSTLAGR VSAAHSVLAS ASVAHVLAAR TAVLQRRRSR VSGPLHHSSL GLQKDIVELL TQSNTAAAIE LGNLLTSHEM EGLLLAHDRI ANHTDGTPSP TPTPTPAIGA ATGSTLSSPV AGPKRNLGMV VPPPVVPPPL AQRGAMPLPR GESPPPVPMP PLATMPMSMP VNLPMSACFG TLNDQNDNIR IIQIEKSTEP LGATVRNEGE AVVIGRIVRG GAAEKSGLLH EGDEILEVNG QELRGKTVNE VCALLGAMQG TLTFLIVPAG SPPSVGVMGG TTGSQLAGLG GAHRDTAVLH VRAHFDYDPE DDLYIPCREL GISFQKGDVL HVISREDPNW WQAYREGEED QTLAGLIPSQ SFQHQRETMK LAIAEEAGLA RSRGKDGSGS KGATLLCARK GRKKKKKASS EAGYPLYATT APDETDPEEI LTYEEVALYY PRATHKRPIV LIGPPNIGRH ELRQRLMADS ERFSAAVPHT SRARREGEVP GVDYHFITRQ AFEADILARR FVEHGEYEKA YYGTSLEAIR TVVASGKICV LNLHPQSLKL LRASDLKPYV VLVAPPSLDK LRQKKLRNGE PFKEEELKDI IATARDMEAR WGHLFDMIII NNDTERAYHQ LLAEINSLER EPQWVPAQWV HNNRDES //