ID Q7KVG9_DROME Unreviewed; 596 AA. AC Q7KVG9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2024, entry version 168. DE SubName: Full=Chip, isoform B {ECO:0000313|EMBL:AAM68293.2}; DE SubName: Full=RE67266p {ECO:0000313|EMBL:ADI46811.1}; GN Name=Chi {ECO:0000313|EMBL:AAM68293.2, GN ECO:0000313|FlyBase:FBgn0013764}; GN Synonyms=chi {ECO:0000313|EMBL:AAM68293.2}, Chi-RB GN {ECO:0000313|EMBL:ADI46811.1}, CHIP {ECO:0000313|EMBL:AAM68293.2}, GN chip {ECO:0000313|EMBL:AAM68293.2}, dLdb GN {ECO:0000313|EMBL:AAM68293.2}, dLDB/Chip GN {ECO:0000313|EMBL:AAM68293.2}, Dmel\CG3924 GN {ECO:0000313|EMBL:AAM68293.2}, l(2)04405 GN {ECO:0000313|EMBL:AAM68293.2}, l(2)k04405 GN {ECO:0000313|EMBL:AAM68293.2}, LDB {ECO:0000313|EMBL:AAM68293.2}, Ldb GN {ECO:0000313|EMBL:AAM68293.2}; GN ORFNames=CG3924 {ECO:0000313|EMBL:AAM68293.2, GN ECO:0000313|FlyBase:FBgn0013764}, Dmel_CG3924 GN {ECO:0000313|EMBL:AAM68293.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:ADI46811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:ADI46811.1}; RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the LDB family. {ECO:0000256|ARBA:ARBA00006928, CC ECO:0000256|PROSITE-ProRule:PRU01302}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AAM68293.2; -; Genomic_DNA. DR EMBL; BT125015; ADI46811.1; -; mRNA. DR RefSeq; NP_726403.2; NM_166650.2. DR AlphaFoldDB; Q7KVG9; -. DR SMR; Q7KVG9; -. DR ComplexPortal; CPX-2563; Wnt enhanceosome complex. DR STRING; 7227.FBpp0072101; -. DR PaxDb; 7227-FBpp0072101; -. DR DNASU; 37837; -. DR EnsemblMetazoa; FBtr0072192; FBpp0072101; FBgn0013764. DR GeneID; 37837; -. DR UCSC; CG3924-RB; d. melanogaster. DR AGR; FB:FBgn0013764; -. DR CTD; 37837; -. DR FlyBase; FBgn0013764; Chi. DR VEuPathDB; VectorBase:FBgn0013764; -. DR eggNOG; KOG2181; Eukaryota. DR GeneTree; ENSGT00390000005639; -. DR HOGENOM; CLU_019283_0_0_1; -. DR InParanoid; Q7KVG9; -. DR OMA; HMAVRTH; -. DR OrthoDB; 1369602at2759; -. DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs. DR BioGRID-ORCS; 37837; 0 hits in 3 CRISPR screens. DR ChiTaRS; chic; fly. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0013764; Expressed in oviduct (Drosophila) and 26 other cell types or tissues. DR ExpressionAtlas; Q7KVG9; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central. DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:FlyBase. DR GO; GO:0030274; F:LIM domain binding; IBA:GO_Central. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:FlyBase. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0007350; P:blastoderm segmentation; TAS:FlyBase. DR GO; GO:0022416; P:chaeta development; IMP:FlyBase. DR GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0070983; P:dendrite guidance; IMP:FlyBase. DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007399; P:nervous system development; IMP:FlyBase. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:FlyBase. DR GO; GO:0007563; P:regulation of eclosion; IMP:FlyBase. DR GO; GO:0010468; P:regulation of gene expression; IMP:FlyBase. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1. DR InterPro; IPR041363; LID. DR InterPro; IPR029005; LIM-bd/SEUSS. DR PANTHER; PTHR10378:SF24; CHIP, ISOFORM B; 1. DR PANTHER; PTHR10378; LIM DOMAIN-BINDING PROTEIN; 1. DR Pfam; PF17916; LID; 1. DR Pfam; PF01803; LIM_bind; 1. DR PROSITE; PS51957; LID; 1. PE 2: Evidence at transcript level; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 503..542 FT /note="LIM interaction" FT /evidence="ECO:0000259|PROSITE:PS51957" FT REGION 1..215 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 449..501 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 536..596 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 22..40 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..75 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 83..146 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 158..191 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 473..501 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 574..596 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 596 AA; 64779 MW; B7BB0687580A46D5 CRC64; MQCDIQTSRR ECPIEPTTGM NRRGLNAGNT MTSQANIDDG SWKAVSEGGS MLPASNSAVL NPDGSNQSGF AQGGLPYNSA GNPYPPAGQS SPAGNQSIVF QNSNQPGSNT PQYTSSPAPS GSSTPGPVGA QNIPGNYPQS ATAGNFNGPV GGPFGSPSSG LGQFSRPASS GTPFNSGQAG HFSSPTVFSV GGQFNPMPPA SPFGHGGNHP MMGGPQQMER IDQGFRRHNS YFSHTEHRVF ELNKRLQQRN EESDNCWWDS FTTEFFEDDA RLTILFCLED GPKRYTIGRT LIPRFFRSIY EGGVSDLYFQ LKHAKESFHN TSITLDCDQC TVITQHGKPF FTKVCADARL ILEFMYDDYM RIKSWHMTIK GHRELIPRSV IGTSLPPDPM LLDQITKNIT RAGITNSTLN YLRLCVILEP MQELMSRHKA YALSPRDCLK TTLFQKWQRM VAPPGKKDPQ RPPNKRRKRK GSNSGGGNNS NTPPVTNQKR SPSGPSFSLS SQDVMVVGEP TLMGGEFGEE DERLITRLEN TQYDGTNAVE HDNHTGFGHA DSPISGSNPW SIDRAGAIPA SPGNGAAPQN NANISDIDKK SPIVSQ //