ID Q7KVG9_DROME Unreviewed; 596 AA. AC Q7KVG9; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 16-OCT-2019, entry version 144. DE SubName: Full=Chip, isoform B {ECO:0000313|EMBL:AAM68293.2}; DE SubName: Full=RE67266p {ECO:0000313|EMBL:ADI46811.1}; GN Name=Chi {ECO:0000313|EMBL:AAM68293.2, GN ECO:0000313|FlyBase:FBgn0013764}; GN Synonyms=chi {ECO:0000313|EMBL:AAM68293.2}, Chi-RB GN {ECO:0000313|EMBL:ADI46811.1}, CHIP {ECO:0000313|EMBL:AAM68293.2}, GN Chip {ECO:0000313|EMBL:AAM68293.2}, chip GN {ECO:0000313|EMBL:AAM68293.2}, dLDB {ECO:0000313|EMBL:AAM68293.2}, GN dLdb {ECO:0000313|EMBL:AAM68293.2}, Dmel\CG3924 GN {ECO:0000313|EMBL:AAM68293.2}, l(2)04405 GN {ECO:0000313|EMBL:AAM68293.2}, l(2)k04405 GN {ECO:0000313|EMBL:AAM68293.2}, LDB {ECO:0000313|EMBL:AAM68293.2}, Ldb GN {ECO:0000313|EMBL:AAM68293.2}; GN ORFNames=CG3924 {ECO:0000313|EMBL:AAM68293.2, GN ECO:0000313|FlyBase:FBgn0013764}, Dmel_CG3924 GN {ECO:0000313|EMBL:AAM68293.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAM68293.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:ADI46811.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:ADI46811.1}; RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAM68293.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; AAM68293.2; -; Genomic_DNA. DR EMBL; BT125015; ADI46811.1; -; mRNA. DR RefSeq; NP_726403.2; NM_166650.2. DR SMR; Q7KVG9; -. DR STRING; 7227.FBpp0072101; -. DR PRIDE; Q7KVG9; -. DR EnsemblMetazoa; FBtr0072192; FBpp0072101; FBgn0013764. DR GeneID; 37837; -. DR UCSC; CG3924-RB; d. melanogaster. DR CTD; 37837; -. DR FlyBase; FBgn0013764; Chi. DR eggNOG; KOG2181; Eukaryota. DR eggNOG; ENOG410YZVH; LUCA. DR GeneTree; ENSGT00390000005639; -. DR OMA; RRGLNTG; -. DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs. DR ChiTaRS; chic; fly. DR GenomeRNAi; 37837; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0013764; Expressed in 35 organ(s), highest expression level in embryo. DR ExpressionAtlas; Q7KVG9; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0030274; F:LIM domain binding; IBA:GO_Central. DR GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IBA:GO_Central. DR GO; GO:0001085; F:RNA polymerase II transcription factor binding; IPI:FlyBase. DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro. DR GO; GO:0008134; F:transcription factor binding; IPI:FlyBase. DR GO; GO:0007411; P:axon guidance; IMP:FlyBase. DR GO; GO:0007350; P:blastoderm segmentation; TAS:FlyBase. DR GO; GO:0022416; P:chaeta development; IMP:FlyBase. DR GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0070983; P:dendrite guidance; IMP:FlyBase. DR GO; GO:0035050; P:embryonic heart tube development; IMP:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0007275; P:multicellular organism development; IBA:GO_Central. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central. DR GO; GO:0007399; P:nervous system development; IMP:FlyBase. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:FlyBase. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:FlyBase. DR GO; GO:0007563; P:regulation of eclosion; IMP:FlyBase. DR GO; GO:0010468; P:regulation of gene expression; IMP:FlyBase. DR InterPro; IPR030174; LDB2. DR InterPro; IPR041363; LID. DR InterPro; IPR029005; LIM-bd/SEUSS. DR PANTHER; PTHR10378; PTHR10378; 1. DR PANTHER; PTHR10378:SF8; PTHR10378:SF8; 1. DR Pfam; PF17916; LID; 1. DR Pfam; PF01803; LIM_bind; 2. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 503 531 LID. {ECO:0000259|Pfam:PF17916}. FT REGION 1 215 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 449 501 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 536 596 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 22 40 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 50 75 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 83 146 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 158 191 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 473 501 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 574 596 Polar. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 596 AA; 64779 MW; B7BB0687580A46D5 CRC64; MQCDIQTSRR ECPIEPTTGM NRRGLNAGNT MTSQANIDDG SWKAVSEGGS MLPASNSAVL NPDGSNQSGF AQGGLPYNSA GNPYPPAGQS SPAGNQSIVF QNSNQPGSNT PQYTSSPAPS GSSTPGPVGA QNIPGNYPQS ATAGNFNGPV GGPFGSPSSG LGQFSRPASS GTPFNSGQAG HFSSPTVFSV GGQFNPMPPA SPFGHGGNHP MMGGPQQMER IDQGFRRHNS YFSHTEHRVF ELNKRLQQRN EESDNCWWDS FTTEFFEDDA RLTILFCLED GPKRYTIGRT LIPRFFRSIY EGGVSDLYFQ LKHAKESFHN TSITLDCDQC TVITQHGKPF FTKVCADARL ILEFMYDDYM RIKSWHMTIK GHRELIPRSV IGTSLPPDPM LLDQITKNIT RAGITNSTLN YLRLCVILEP MQELMSRHKA YALSPRDCLK TTLFQKWQRM VAPPGKKDPQ RPPNKRRKRK GSNSGGGNNS NTPPVTNQKR SPSGPSFSLS SQDVMVVGEP TLMGGEFGEE DERLITRLEN TQYDGTNAVE HDNHTGFGHA DSPISGSNPW SIDRAGAIPA SPGNGAAPQN NANISDIDKK SPIVSQ //