ID Q7KU30_DROME Unreviewed; 1017 AA. AC Q7KU30; Q9VQP3; Q9VQP4; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 03-JUL-2019, entry version 158. DE SubName: Full=Early gene at 23, isoform C {ECO:0000313|EMBL:AAS64617.1}; DE EC=3.6.1.3 {ECO:0000313|EMBL:AAF51121.3, ECO:0000313|EMBL:AAF51122.3, ECO:0000313|EMBL:AAS64617.1}; DE EC=3.6.3.- {ECO:0000313|EMBL:AAF51121.3, ECO:0000313|EMBL:AAF51122.3, ECO:0000313|EMBL:AAS64617.1}; DE SubName: Full=Early gene at 23, isoform D {ECO:0000313|EMBL:AAF51121.3}; DE SubName: Full=Early gene at 23, isoform E {ECO:0000313|EMBL:AAF51122.3}; DE SubName: Full=FI20292p1 {ECO:0000313|EMBL:AFH68356.1}; GN Name=E23 {ECO:0000313|EMBL:AAS64617.1, GN ECO:0000313|FlyBase:FBgn0020445}; GN Synonyms=CG15410 {ECO:0000313|EMBL:AAS64617.1}, Dmel\CG3327 GN {ECO:0000313|EMBL:AAS64617.1}, E23-RC {ECO:0000313|EMBL:AFH68356.1}; GN ORFNames=CG3327 {ECO:0000313|EMBL:AAF51122.3, GN ECO:0000313|FlyBase:FBgn0020445}, Dmel_CG3327 GN {ECO:0000313|EMBL:AAS64617.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAS64617.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAS64617.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAS64617.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AFH68356.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAS64617.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAS64617.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAS64617.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAF51121.3; -; Genomic_DNA. DR EMBL; AE014134; AAF51122.3; -; Genomic_DNA. DR EMBL; AE014134; AAS64617.1; -; Genomic_DNA. DR EMBL; BT133432; AFH68356.1; -; mRNA. DR RefSeq; NP_524648.3; NM_079909.3. DR RefSeq; NP_608768.2; NM_134924.2. DR RefSeq; NP_995622.1; NM_205900.2. DR IntAct; Q7KU30; 6. DR STRING; 7227.FBpp0088917; -. DR EnsemblMetazoa; FBtr0089979; FBpp0088917; FBgn0020445. DR EnsemblMetazoa; FBtr0339548; FBpp0308631; FBgn0020445. DR EnsemblMetazoa; FBtr0339549; FBpp0308632; FBgn0020445. DR GeneID; 43895; -. DR KEGG; dme:Dmel_CG3327; -. DR UCSC; CG3327-RA; d. melanogaster. DR UCSC; CG3327-RB; d. melanogaster. DR UCSC; CG3327-RC; d. melanogaster. DR CTD; 43895; -. DR FlyBase; FBgn0020445; E23. DR eggNOG; KOG0061; Eukaryota. DR eggNOG; COG1131; LUCA. DR OMA; SHGNYLN; -. DR OrthoDB; 1022017at2759; -. DR Reactome; R-DME-1369062; ABC transporters in lipid homeostasis. DR ChiTaRS; E23; fly. DR GenomeRNAi; 43895; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0020445; Expressed in 26 organ(s), highest expression level in Malpighian tubule. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016887; F:ATPase activity; IEA:UniProtKB-EC. DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; ISS:FlyBase. DR GO; GO:0042752; P:regulation of circadian rhythm; IDA:FlyBase. DR GO; GO:0055085; P:transmembrane transport; ISS:FlyBase. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR013525; ABC_2_trans. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF01061; ABC2_membrane; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|SAAS:SAAS00555301}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Hydrolase {ECO:0000313|EMBL:AAS64617.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434, KW ECO:0000256|SAAS:SAAS00555311}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 791 812 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 833 855 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 867 891 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 898 917 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 986 1008 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 353 590 ABC transporter. {ECO:0000259|PROSITE: FT PS50893}. FT NP_BIND 385 392 ATP. {ECO:0000256|PROSITE-ProRule: FT PRU00434}. FT REGION 28 61 Disordered. {ECO:0000256|MobiDB-lite: FT Q7KU30}. FT REGION 247 289 Disordered. {ECO:0000256|MobiDB-lite: FT Q7KU30}. SQ SEQUENCE 1017 AA; 112352 MW; D3F096E05E6EC76F CRC64; MIISKDLFIF GEQIFATIIP EGGAAALATQ QQHQQQHQQQ HQQSHQQPHQ QSQQQQQQQQ PAIINSTTTT ATSLVINSTA GAAEQVVEES LKVAAAAAAA TTTTTAAAAT TLPAKQETVA VAAACVAPRK LAKIQKIPKE PEELKAKKKA KCEAAAAATH YEKMPMNLMI VESVEAVDMG SSDNDNETTE QVPLVSASRR NLAKIVADCR LQIEVEPATS AVAAAAAAAA SVASPPATSD ATAATSVASS DSSASSSASS TSSSSSSSTS SEFTHTSQTT IPSTDNLTSS NGLANIGKSI LVDAKSNSPA SLSYHFEKSA AANQQKQHHN INICNSHHPH HHSQNQPQHS LQLTFQNLNV LHNERQILSD VSGFVSPCEV LAIMGPSGSG KTTLLDCLSG QRHIDSGSVF LNREPLTKKW RRRIGYVLQE EIFFPQLTLR ETVVYTALLR LPESMPRAEK MRQVDHILEA LELGCCQQTK FGDYLNRGLS GGEKKRANIA CELLTNPLLM LLDEPTSGLD SHSAISLMKV LKRYAQLEQK TIVISVHQPS SQMFHMFDKL LLLHQGRTAY FGDVQNIYRH FEDIGVTIKP HYNPADFVLE QLKSHPDIRE KLFIAAKESH GNYLNRNCIT SSHHNQVSVS GAKGKKQADS ILIDDIINNY YNQRSNRHHH QYENLHHTSN GCRVEEDEEA AQHLVWCAAD SQSNFSSCAS SDCHSYSAGS GPGHSADDDW LSYPTSFHTQ FCVLSSRNFR EAKPRMLSKL NWFQTIGLAL MAGAIWFQLP RTEEFLHDLQ GWMFFSQTYW MLFALFGALN SFPSEREVVS KERRSGAYRL SAYYLAKMCA ELPLVITLPT VYLMISYPML GCTSLKLFFL MLIFLLINTI VAQSVGFFIG ACCMDMNVSI TLSALYTLAT QLFGGYLSSR IPEGLSWIRY TSMIHYAYQN MQILEFREGA AIGCGSPSSY EICKQQSTEF IPYEEILKAQ NSTSPLWLNT LILMMFFLVF RCLGYAVLRF LRCPKKT //