ID Q7KTI7_DROME Unreviewed; 1215 AA. AC Q7KTI7; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 28-NOV-2012, entry version 96. DE SubName: Full=PDGF-and VEGF-receptor related, isoform F; DE EC=2.7.10.-; DE EC=2.7.10.1; GN Name=Pvr; ORFNames=Dmel_CG8222; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a CC [protein]-L-tyrosine phosphate. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAS64657.1; -; Genomic_DNA. DR RefSeq; NP_995647.1; NM_205925.2. DR UniGene; Dm.4698; -. DR HSSP; P11362; 1AGW. DR ProteinModelPortal; Q7KTI7; -. DR SMR; Q7KTI7; 1-213, 295-493, 555-975. DR STRING; Q7KTI7; -. DR PRIDE; Q7KTI7; -. DR EnsemblMetazoa; FBtr0079630; FBpp0089340; FBgn0032006. DR GeneID; 34127; -. DR KEGG; dme:Dmel_CG8222; -. DR UCSC; CG8222-RF; d. melanogaster. DR CTD; 5817; -. DR GeneTree; ENSGT00660000095142; -. DR InParanoid; Q7KTI7; -. DR KO; K05096; -. DR OrthoDB; EOG4XD265; -. DR GenomeRNAi; 34127; -. DR NextBio; 786990; -. DR ArrayExpress; Q7KTI7; -. DR Bgee; Q7KTI7; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IPI:FlyBase. DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase. DR GO; GO:0061327; P:anterior Malpighian tubule development; IMP:FlyBase. DR GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase. DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase. DR GO; GO:0030031; P:cell projection assembly; IMP:FlyBase. DR GO; GO:0035099; P:hemocyte migration; IMP:FlyBase. DR GO; GO:0035172; P:hemocyte proliferation; TAS:FlyBase. DR GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase. DR GO; GO:0007443; P:Malpighian tubule morphogenesis; IMP:FlyBase. DR GO; GO:0000022; P:mitotic spindle elongation; IMP:FlyBase. DR GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase. DR GO; GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase. DR GO; GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase. DR GO; GO:0007419; P:ventral cord development; IMP:FlyBase. DR Gene3D; 2.60.40.10; Ig-like_fold; 5. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_cat_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR Pfam; PF07679; I-set; 3. DR Pfam; PF07714; Pkinase_Tyr; 1. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; KW Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; KW Reference proteome; Repeat; Transferase; Transmembrane; KW Transmembrane helix; Tyrosine-protein kinase. SQ SEQUENCE 1215 AA; 137254 MW; 0EFE908A7192B42E CRC64; MEWFTPSRDE NRIFASQSRT DPKTRNSTHQ TGRSTLTVLN AQPSDTGLYK CVTTDNSNQN VQRATYRIKV LKQNESYLNV GEPSGHYNVQ EYANRTIQMT ANFEGFPTPS FSWFKPDGTE VRQSENNFKI LSTELSTMLQ VLNAQLQDSG TYVLRGSNSF GVVQREYNVS VMDAPALKMS DAYVQVGSVA RLECTVRSYP PAIVTFFFRP CSLEPQWPTC SVLNQNFSLP SEQEKYQFQT RPRPGKLSVE RIYEVSFLPT EPGILTCIAQ NIIDGKERRT LTKAHVLLGN ISENMTIYGF DKDHKIAKED NVNFTCEALA YHFDGNLKWF INGEDLKESD SVHIETSHTK YSYKSTVHIT TISDRDRGTY ECRAYHNDKD AVYSSREIDL YVHDPSAPQW TNGGQEGHSK IKRKLSQTLE LECASTAVPV AIVRWFKDDK EVTESKLRHI IEKESKLLIT HLYPGDEGVY KCVVENRLDR IERSFTVVIS DLPGISMAWV WFGVILFLIL IGLCVFLAVR YQKEHKRHLA LKAAGLANFE EGAVGHINPD LTLDEQAELL PYNREFEFPR ENLKLGKQLG AGAFGVVLKG EAKGIRREEP TTTVAVKMVK ATADNEVVRA LVSELKIMVH LGQHLNVVNL LGAVTKNIAK RELMVIVEYC RFGNIQNFLL RNRKCFINQI NPDTDHIDPS IMTQRMSDNY ELHRDTNGGG LKYANVGFPI HSYINEPHNN NTQPPTHRRN SDNDPRSGTR AGRTGSGTAT YSYDRQMDTC ATVMTTVPED DQIMSNNSVQ PAWRSNYKTD STEAMTVTTV DLISWAFQVA RGMDYLSSKK VLHGDLAARN ILLCEDNVVK ICDFGLARSM YRGDNYKKSE NGKLPIKWLA LESLSDHVFS TYSDVWSYGI VLWEMFSLAK VPYPGIDPNQ ELFNKLNDGY RMEKPKFANQ ELYEIMLECW RKNPESRPLF AELEKRFANM LGEDVASHYL DLNNPYMQSN IEYMKKQSTD YLALMGSPDE LAPAAPRYVN GHIVPDIRIE ELPDDYMEMS RDSDPDACTA IFSPTRLEGE SSDFPDFSSE TTFNFPGARQ SPTLSNNLNS GSSKPLRKKN GMPTVDVADQ APEEIPMLHR SSTGSDGSPE QGRRFNQALK QQYVTPTPSP RHHVETKLNG EPSENYVNMK PPRKNIPGKT TTGGGGAAAG ASTEAFSNPS YQPLSTVNEK EQRRY //