ID   Q7KTI7_DROME            Unreviewed;      1215 AA.
AC   Q7KTI7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   01-SEP-2009, entry version 63.
DE   SubName: Full=PDGF-and VEGF-receptor related, isoform F;
DE            EC=2.7.10.-;
DE            EC=2.7.10.1;
GN   Name=Pvr; ORFNames=Dmel_CG8222;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
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DR   EMBL; AE014134; AAS64657.1; -; Genomic_DNA.
DR   RefSeq; NP_995647.1; -.
DR   UniGene; Dm.4698; -.
DR   HSSP; P11362; 1AGW.
DR   IntAct; Q7KTI7; 1.
DR   STRING; Q7KTI7; -.
DR   PRIDE; Q7KTI7; -.
DR   Ensembl; FBtr0079628; FBpp0089341; FBgn0032006; Drosophila melanogaster.
DR   GeneID; 34127; -.
DR   UCSC; CG8222-RF; d. melanogaster.
DR   CTD; 34127; -.
DR   FlyBase; FBgn0032006; Pvr.
DR   NextBio; 786990; -.
DR   ArrayExpress; Q7KTI7; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:FlyBase.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kin...; IPI:FlyBase.
DR   GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR   GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
DR   GO; GO:0007298; P:border follicle cell migration; IGI:FlyBase.
DR   GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR   GO; GO:0007298; P:border follicle cell migration; TAS:FlyBase.
DR   GO; GO:0030031; P:cell projection assembly; IMP:FlyBase.
DR   GO; GO:0035099; P:hemocyte migration; IMP:FlyBase.
DR   GO; GO:0035099; P:hemocyte migration; TAS:FlyBase.
DR   GO; GO:0035172; P:hemocyte proliferation; TAS:FlyBase.
DR   GO; GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; NAS:FlyBase.
DR   GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase.
DR   GO; GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase.
DR   GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR   GO; GO:0007419; P:ventral cord development; IMP:FlyBase.
DR   InterPro; IPR013151; Ig.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00047; ig; 2.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF07686; V-set; 1.
DR   ProDom; PD000001; Prot_kinase; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; UNKNOWN_1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Complete proteome; Immunoglobulin domain; Kinase;
KW   Membrane; Nucleotide-binding; Receptor; Transferase; Transmembrane;
KW   Tyrosine-protein kinase.
SQ   SEQUENCE   1215 AA;  137254 MW;  0EFE908A7192B42E CRC64;
     MEWFTPSRDE NRIFASQSRT DPKTRNSTHQ TGRSTLTVLN AQPSDTGLYK CVTTDNSNQN
     VQRATYRIKV LKQNESYLNV GEPSGHYNVQ EYANRTIQMT ANFEGFPTPS FSWFKPDGTE
     VRQSENNFKI LSTELSTMLQ VLNAQLQDSG TYVLRGSNSF GVVQREYNVS VMDAPALKMS
     DAYVQVGSVA RLECTVRSYP PAIVTFFFRP CSLEPQWPTC SVLNQNFSLP SEQEKYQFQT
     RPRPGKLSVE RIYEVSFLPT EPGILTCIAQ NIIDGKERRT LTKAHVLLGN ISENMTIYGF
     DKDHKIAKED NVNFTCEALA YHFDGNLKWF INGEDLKESD SVHIETSHTK YSYKSTVHIT
     TISDRDRGTY ECRAYHNDKD AVYSSREIDL YVHDPSAPQW TNGGQEGHSK IKRKLSQTLE
     LECASTAVPV AIVRWFKDDK EVTESKLRHI IEKESKLLIT HLYPGDEGVY KCVVENRLDR
     IERSFTVVIS DLPGISMAWV WFGVILFLIL IGLCVFLAVR YQKEHKRHLA LKAAGLANFE
     EGAVGHINPD LTLDEQAELL PYNREFEFPR ENLKLGKQLG AGAFGVVLKG EAKGIRREEP
     TTTVAVKMVK ATADNEVVRA LVSELKIMVH LGQHLNVVNL LGAVTKNIAK RELMVIVEYC
     RFGNIQNFLL RNRKCFINQI NPDTDHIDPS IMTQRMSDNY ELHRDTNGGG LKYANVGFPI
     HSYINEPHNN NTQPPTHRRN SDNDPRSGTR AGRTGSGTAT YSYDRQMDTC ATVMTTVPED
     DQIMSNNSVQ PAWRSNYKTD STEAMTVTTV DLISWAFQVA RGMDYLSSKK VLHGDLAARN
     ILLCEDNVVK ICDFGLARSM YRGDNYKKSE NGKLPIKWLA LESLSDHVFS TYSDVWSYGI
     VLWEMFSLAK VPYPGIDPNQ ELFNKLNDGY RMEKPKFANQ ELYEIMLECW RKNPESRPLF
     AELEKRFANM LGEDVASHYL DLNNPYMQSN IEYMKKQSTD YLALMGSPDE LAPAAPRYVN
     GHIVPDIRIE ELPDDYMEMS RDSDPDACTA IFSPTRLEGE SSDFPDFSSE TTFNFPGARQ
     SPTLSNNLNS GSSKPLRKKN GMPTVDVADQ APEEIPMLHR SSTGSDGSPE QGRRFNQALK
     QQYVTPTPSP RHHVETKLNG EPSENYVNMK PPRKNIPGKT TTGGGGAAAG ASTEAFSNPS
     YQPLSTVNEK EQRRY
//