ID   Q7KTI7_DROME            Unreviewed;      1215 AA.
AC   Q7KTI7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   02-OCT-2007, entry version 39.
DE   CG8222-PF, isoform F.
GN   Name=Pvr; ORFNames=Dmel_CG8222;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22426065; PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   (er) Genome Biol. 3 (12), RESEARCH0079 (2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22426070; PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RG   Drosophila Heterochromatin Genome Project;
RA   Smith C.D., Shu S., Yandell M.D., Karpen G.H.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R.,
RA   Park S., Svirskas R., Karpen G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
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DR   EMBL; AE014134; AAS64657.1; -; Genomic_DNA.
DR   RefSeq; NP_995647.1; -.
DR   UniGene; Dm.4698; -.
DR   HSSP; P11362; 1AGW.
DR   Ensembl; CG8222; Drosophila melanogaster.
DR   KEGG; dme:CG8222-PF; -.
DR   FlyBase; FBgn0032006; Pvr.
DR   ArrayExpress; Q7KTI7; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004713; F:protein-tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR013151; Ig.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00047; ig; 2.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF07686; V-set; 1.
DR   ProDom; PD000001; Prot_kinase; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; UNKNOWN_1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; UNKNOWN_1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Immunoglobulin domain; Kinase;
KW   Membrane; Nucleotide-binding; Receptor; Repeat; Transferase;
KW   Transmembrane; Tyrosine-protein kinase.
SQ   SEQUENCE   1215 AA;  137254 MW;  0EFE908A7192B42E CRC64;
     MEWFTPSRDE NRIFASQSRT DPKTRNSTHQ TGRSTLTVLN AQPSDTGLYK CVTTDNSNQN
     VQRATYRIKV LKQNESYLNV GEPSGHYNVQ EYANRTIQMT ANFEGFPTPS FSWFKPDGTE
     VRQSENNFKI LSTELSTMLQ VLNAQLQDSG TYVLRGSNSF GVVQREYNVS VMDAPALKMS
     DAYVQVGSVA RLECTVRSYP PAIVTFFFRP CSLEPQWPTC SVLNQNFSLP SEQEKYQFQT
     RPRPGKLSVE RIYEVSFLPT EPGILTCIAQ NIIDGKERRT LTKAHVLLGN ISENMTIYGF
     DKDHKIAKED NVNFTCEALA YHFDGNLKWF INGEDLKESD SVHIETSHTK YSYKSTVHIT
     TISDRDRGTY ECRAYHNDKD AVYSSREIDL YVHDPSAPQW TNGGQEGHSK IKRKLSQTLE
     LECASTAVPV AIVRWFKDDK EVTESKLRHI IEKESKLLIT HLYPGDEGVY KCVVENRLDR
     IERSFTVVIS DLPGISMAWV WFGVILFLIL IGLCVFLAVR YQKEHKRHLA LKAAGLANFE
     EGAVGHINPD LTLDEQAELL PYNREFEFPR ENLKLGKQLG AGAFGVVLKG EAKGIRREEP
     TTTVAVKMVK ATADNEVVRA LVSELKIMVH LGQHLNVVNL LGAVTKNIAK RELMVIVEYC
     RFGNIQNFLL RNRKCFINQI NPDTDHIDPS IMTQRMSDNY ELHRDTNGGG LKYANVGFPI
     HSYINEPHNN NTQPPTHRRN SDNDPRSGTR AGRTGSGTAT YSYDRQMDTC ATVMTTVPED
     DQIMSNNSVQ PAWRSNYKTD STEAMTVTTV DLISWAFQVA RGMDYLSSKK VLHGDLAARN
     ILLCEDNVVK ICDFGLARSM YRGDNYKKSE NGKLPIKWLA LESLSDHVFS TYSDVWSYGI
     VLWEMFSLAK VPYPGIDPNQ ELFNKLNDGY RMEKPKFANQ ELYEIMLECW RKNPESRPLF
     AELEKRFANM LGEDVASHYL DLNNPYMQSN IEYMKKQSTD YLALMGSPDE LAPAAPRYVN
     GHIVPDIRIE ELPDDYMEMS RDSDPDACTA IFSPTRLEGE SSDFPDFSSE TTFNFPGARQ
     SPTLSNNLNS GSSKPLRKKN GMPTVDVADQ APEEIPMLHR SSTGSDGSPE QGRRFNQALK
     QQYVTPTPSP RHHVETKLNG EPSENYVNMK PPRKNIPGKT TTGGGGAAAG ASTEAFSNPS
     YQPLSTVNEK EQRRY
//