ID Q7KTI7_DROME Unreviewed; 1215 AA. AC Q7KTI7; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2007, entry version 37. DE CG8222-PF, isoform F. GN Name=Pvr; ORFNames=Dmel_CG8222; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426065; PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL (er) Genome Biol. 3 (12), RESEARCH0079 (2002). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426070; PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [6] RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE. RG Drosophila Heterochromatin Genome Project; RA Smith C.D., Shu S., Yandell M.D., Karpen G.H.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., RA Park S., Svirskas R., Karpen G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the Tyr protein kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAS64657.1; -; Genomic_DNA. DR UniGene; Dm.4698; -. DR HSSP; P11362; 1AGW. DR Ensembl; CG8222; Drosophila melanogaster. DR KEGG; dme:CG8222-PF; -. DR FlyBase; FBgn0032006; Pvr. DR ArrayExpress; Q7KTI7; -. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004713; F:protein-tyrosine kinase activity; IEA:InterPro. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro. DR InterPro; IPR013151; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003006; Ig_MHC. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR001245; Tyr_pkinase. DR InterPro; IPR008266; Tyr_pkinase_AS. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2. DR Pfam; PF07679; I-set; 1. DR Pfam; PF00047; ig; 2. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF07686; V-set; 1. DR ProDom; PD000001; Prot_kinase; 2. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 1. DR SMART; SM00219; TyrKc; 1. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00290; IG_MHC; UNKNOWN_1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; UNKNOWN_1. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; KW Membrane; Nucleotide-binding; Receptor; Repeat; Transferase; KW Transmembrane; Tyrosine-protein kinase. SQ SEQUENCE 1215 AA; 137254 MW; 0EFE908A7192B42E CRC64; MEWFTPSRDE NRIFASQSRT DPKTRNSTHQ TGRSTLTVLN AQPSDTGLYK CVTTDNSNQN VQRATYRIKV LKQNESYLNV GEPSGHYNVQ EYANRTIQMT ANFEGFPTPS FSWFKPDGTE VRQSENNFKI LSTELSTMLQ VLNAQLQDSG TYVLRGSNSF GVVQREYNVS VMDAPALKMS DAYVQVGSVA RLECTVRSYP PAIVTFFFRP CSLEPQWPTC SVLNQNFSLP SEQEKYQFQT RPRPGKLSVE RIYEVSFLPT EPGILTCIAQ NIIDGKERRT LTKAHVLLGN ISENMTIYGF DKDHKIAKED NVNFTCEALA YHFDGNLKWF INGEDLKESD SVHIETSHTK YSYKSTVHIT TISDRDRGTY ECRAYHNDKD AVYSSREIDL YVHDPSAPQW TNGGQEGHSK IKRKLSQTLE LECASTAVPV AIVRWFKDDK EVTESKLRHI IEKESKLLIT HLYPGDEGVY KCVVENRLDR IERSFTVVIS DLPGISMAWV WFGVILFLIL IGLCVFLAVR YQKEHKRHLA LKAAGLANFE EGAVGHINPD LTLDEQAELL PYNREFEFPR ENLKLGKQLG AGAFGVVLKG EAKGIRREEP TTTVAVKMVK ATADNEVVRA LVSELKIMVH LGQHLNVVNL LGAVTKNIAK RELMVIVEYC RFGNIQNFLL RNRKCFINQI NPDTDHIDPS IMTQRMSDNY ELHRDTNGGG LKYANVGFPI HSYINEPHNN NTQPPTHRRN SDNDPRSGTR AGRTGSGTAT YSYDRQMDTC ATVMTTVPED DQIMSNNSVQ PAWRSNYKTD STEAMTVTTV DLISWAFQVA RGMDYLSSKK VLHGDLAARN ILLCEDNVVK ICDFGLARSM YRGDNYKKSE NGKLPIKWLA LESLSDHVFS TYSDVWSYGI VLWEMFSLAK VPYPGIDPNQ ELFNKLNDGY RMEKPKFANQ ELYEIMLECW RKNPESRPLF AELEKRFANM LGEDVASHYL DLNNPYMQSN IEYMKKQSTD YLALMGSPDE LAPAAPRYVN GHIVPDIRIE ELPDDYMEMS RDSDPDACTA IFSPTRLEGE SSDFPDFSSE TTFNFPGARQ SPTLSNNLNS GSSKPLRKKN GMPTVDVADQ APEEIPMLHR SSTGSDGSPE QGRRFNQALK QQYVTPTPSP RHHVETKLNG EPSENYVNMK PPRKNIPGKT TTGGGGAAAG ASTEAFSNPS YQPLSTVNEK EQRRY //