ID Q7KTI7_DROME Unreviewed; 1499 AA. AC Q7KTI7; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 26-JUN-2013, sequence version 2. DT 18-SEP-2013, entry version 105. DE SubName: Full=PDGF-and VEGF-receptor related, isoform N; DE EC=2.7.10.-; DE EC=2.7.10.1; GN Name=Pvr; ORFNames=CG8222, Dmel_CG8222; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a CC [protein]-L-tyrosine phosphate. CC -!- SIMILARITY: Contains 1 protein kinase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014134; AAS64657.2; -; Genomic_DNA. DR RefSeq; NP_995647.2; NM_205925.3. DR UniGene; Dm.4698; -. DR ProteinModelPortal; Q7KTI7; -. DR PRIDE; Q7KTI7; -. DR GeneID; 34127; -. DR KEGG; dme:Dmel_CG8222; -. DR UCSC; CG8222-RF; d. melanogaster. DR CTD; 5817; -. DR FlyBase; FBgn0032006; Pvr. DR InParanoid; Q7KTI7; -. DR KO; K05096; -. DR OrthoDB; EOG4XD265; -. DR NextBio; 786990; -. DR Bgee; Q7KTI7; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004713; F:protein tyrosine kinase activity; NAS:FlyBase. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase. DR GO; GO:0061327; P:anterior Malpighian tubule development; IMP:FlyBase. DR GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase. DR GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase. DR GO; GO:0030031; P:cell projection assembly; IMP:FlyBase. DR GO; GO:0035099; P:hemocyte migration; IMP:FlyBase. DR GO; GO:0035172; P:hemocyte proliferation; TAS:FlyBase. DR GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase. DR GO; GO:0007443; P:Malpighian tubule morphogenesis; IMP:FlyBase. DR GO; GO:0000022; P:mitotic spindle elongation; IMP:FlyBase. DR GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase. DR GO; GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase. DR GO; GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase. DR GO; GO:0007419; P:ventral cord development; IMP:FlyBase. DR Gene3D; 2.60.40.10; -; 5. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR Pfam; PF07679; I-set; 3. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 3. DR SMART; SM00408; IGc2; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF56112; Kinase_like; 1. DR PROSITE; PS50835; IG_LIKE; 4. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 4: Predicted; KW ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; KW Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; KW Reference proteome; Repeat; Transferase; Transmembrane; KW Transmembrane helix; Tyrosine-protein kinase. SQ SEQUENCE 1499 AA; 168872 MW; 4F0DE90513697B13 CRC64; MAMLPRLILL PLLLILRISW SDAVPLQQFS PDPDDSIENC GGENGAPLMT PCKSAIILDA QTSTTLKCED DEPMSWWTSQ SQYVHVKSFD NTEDPARPFG TSLHLIEVTA DYVAAYYCVK TSKFSQIAKE EQSDEAMIEL VNQGYASSIY VYVNDPDTKL VDSHNVVTAR QYTDVVIPCK PAMPDTEVLL ETSNGEMHSS KSVGRYDPQR GFTIEIRSIV DGGDYYCRPN PPFPHNEEEM TSIEVRFIGN GHIDNGKPLP KPVIRSSVEH HVFTDTNFTL DCEQSAYVES VYGMEWFTPS RDENRIFASQ SRTDPKTRNS THQTGRSTLT VLNAQPSDTG LYKCVTTDNS NQNVQRATYR IKVLKQNESY LNVGEPSGHY NVQEYANRTI QMTANFEGFP TPSFSWFKPD GTEVRQSENN FKILSTELST MLQVLNAQLQ DSGTYVLRGS NSFGVVQREY NVSVMDAPAL KMSDAYVQVG SVARLECTVR SYPPAIVTFF FRPCSLEPQW PTCSVLNQNF SFQTRPRPGK LSVERIYEVS FLPTEPGILT CIAQNIIDGK ERRTLTKAHV LLGNISENMT IYGFDKDHKI AKEDNVNFTC EALAYHFDGN LKWFINGEDL KESDSVHIET SHTKYSYKST VHITTISDRD RGTYECRAYH NDKDAVYSSR EIDLYVHDPS APQWTNGGQE GHSKIKRKLS QTLELECAST AVPVAIVRWF KDDKEVTESK LRHIIEKESK LLITHLYPGD EGVYKCVVEN RLDRIERSFT VVISDLPGIS MAWVWFGVIL FLILIGLCVF LAVRYQKEHK RHLALKAAGL ANFEEGAVGH INPDLTLDEQ AELLPYNREF EFPRENLKLG KQLGAGAFGV VLKGEAKGIR REEPTTTVAV KMVKATADNE VVRALVSELK IMVHLGQHLN VVNLLGAVTK NIAKRELMVI VEYCRFGNIQ NFLLRNRKCF INQINPDTDH IDPSIMTQRM SDNYELHRDT NGGGLKYANV GFPIHSYINE PHNNNTQPPT HRRNSDNDPR SGTRAGRTGS GTATYSYDRQ MDTCATVMTT VPEDDQIMSN NSVQPAWRSN YKTDSTEAMT VTTVDLISWA FQVARGMDYL SSKKVLHGDL AARNILLCED NVVKICDFGL ARSMYRGDNY KKSENGKLPI KWLALESLSD HVFSTYSDVW SYGIVLWEMF SLAKVPYPGI DPNQELFNKL NDGYRMEKPK FANQELYEIM LECWRKNPES RPLFAELEKR FANMLGEDVA SHYLDLNNPY MQSNIEYMKK QSTDYLALMG SPDELAPAAP RYVNGHIVPD IRIEELPDDY MEMSRDSDPD ACTAIFSPTR LEGESSDFPD FSSETTFNFP GARQSPTLSN NLNSGSSKPL RKKNGMPTVD VADQAPEEIP MLHRSSTGSD GSPEQGRRFN QALKQQYVTP TPSPRHHVET KLNGEPSENY VNMKPPRKNI PGKTTTGGGG AAAGASTEAF SNPSYQPLST VNEKEQRRY //