ID   Q7KTI7_DROME            Unreviewed;      1499 AA.
AC   Q7KTI7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   26-JUN-2013, entry version 103.
DE   SubName: Full=PDGF-and VEGF-receptor related, isoform N;
DE            EC=2.7.10.-;
DE            EC=2.7.10.1;
GN   Name=Pvr; ORFNames=CG8222, Dmel_CG8222;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; AE014134; AAS64657.2; -; Genomic_DNA.
DR   RefSeq; NP_995647.2; NM_205925.3.
DR   UniGene; Dm.4698; -.
DR   ProteinModelPortal; Q7KTI7; -.
DR   SMR; Q7KTI7; 32-489, 560-1070.
DR   PRIDE; Q7KTI7; -.
DR   GeneID; 34127; -.
DR   UCSC; CG8222-RF; d. melanogaster.
DR   CTD; 5817; -.
DR   FlyBase; FBgn0032006; Pvr.
DR   InParanoid; Q7KTI7; -.
DR   OrthoDB; EOG4XD265; -.
DR   GenomeRNAi; 34127; -.
DR   NextBio; 786990; -.
DR   Bgee; Q7KTI7; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; NAS:FlyBase.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC.
DR   GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR   GO; GO:0061327; P:anterior Malpighian tubule development; IMP:FlyBase.
DR   GO; GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
DR   GO; GO:0007298; P:border follicle cell migration; IMP:FlyBase.
DR   GO; GO:0030031; P:cell projection assembly; IMP:FlyBase.
DR   GO; GO:0035099; P:hemocyte migration; IMP:FlyBase.
DR   GO; GO:0035172; P:hemocyte proliferation; TAS:FlyBase.
DR   GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IMP:FlyBase.
DR   GO; GO:0007443; P:Malpighian tubule morphogenesis; IMP:FlyBase.
DR   GO; GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
DR   GO; GO:0008360; P:regulation of cell shape; IMP:FlyBase.
DR   GO; GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase.
DR   GO; GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.
DR   GO; GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.
DR   GO; GO:0007419; P:ventral cord development; IMP:FlyBase.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07679; I-set; 3.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain;
KW   Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor;
KW   Reference proteome; Repeat; Transferase; Transmembrane;
KW   Transmembrane helix; Tyrosine-protein kinase.
SQ   SEQUENCE   1499 AA;  168872 MW;  4F0DE90513697B13 CRC64;
     MAMLPRLILL PLLLILRISW SDAVPLQQFS PDPDDSIENC GGENGAPLMT PCKSAIILDA
     QTSTTLKCED DEPMSWWTSQ SQYVHVKSFD NTEDPARPFG TSLHLIEVTA DYVAAYYCVK
     TSKFSQIAKE EQSDEAMIEL VNQGYASSIY VYVNDPDTKL VDSHNVVTAR QYTDVVIPCK
     PAMPDTEVLL ETSNGEMHSS KSVGRYDPQR GFTIEIRSIV DGGDYYCRPN PPFPHNEEEM
     TSIEVRFIGN GHIDNGKPLP KPVIRSSVEH HVFTDTNFTL DCEQSAYVES VYGMEWFTPS
     RDENRIFASQ SRTDPKTRNS THQTGRSTLT VLNAQPSDTG LYKCVTTDNS NQNVQRATYR
     IKVLKQNESY LNVGEPSGHY NVQEYANRTI QMTANFEGFP TPSFSWFKPD GTEVRQSENN
     FKILSTELST MLQVLNAQLQ DSGTYVLRGS NSFGVVQREY NVSVMDAPAL KMSDAYVQVG
     SVARLECTVR SYPPAIVTFF FRPCSLEPQW PTCSVLNQNF SFQTRPRPGK LSVERIYEVS
     FLPTEPGILT CIAQNIIDGK ERRTLTKAHV LLGNISENMT IYGFDKDHKI AKEDNVNFTC
     EALAYHFDGN LKWFINGEDL KESDSVHIET SHTKYSYKST VHITTISDRD RGTYECRAYH
     NDKDAVYSSR EIDLYVHDPS APQWTNGGQE GHSKIKRKLS QTLELECAST AVPVAIVRWF
     KDDKEVTESK LRHIIEKESK LLITHLYPGD EGVYKCVVEN RLDRIERSFT VVISDLPGIS
     MAWVWFGVIL FLILIGLCVF LAVRYQKEHK RHLALKAAGL ANFEEGAVGH INPDLTLDEQ
     AELLPYNREF EFPRENLKLG KQLGAGAFGV VLKGEAKGIR REEPTTTVAV KMVKATADNE
     VVRALVSELK IMVHLGQHLN VVNLLGAVTK NIAKRELMVI VEYCRFGNIQ NFLLRNRKCF
     INQINPDTDH IDPSIMTQRM SDNYELHRDT NGGGLKYANV GFPIHSYINE PHNNNTQPPT
     HRRNSDNDPR SGTRAGRTGS GTATYSYDRQ MDTCATVMTT VPEDDQIMSN NSVQPAWRSN
     YKTDSTEAMT VTTVDLISWA FQVARGMDYL SSKKVLHGDL AARNILLCED NVVKICDFGL
     ARSMYRGDNY KKSENGKLPI KWLALESLSD HVFSTYSDVW SYGIVLWEMF SLAKVPYPGI
     DPNQELFNKL NDGYRMEKPK FANQELYEIM LECWRKNPES RPLFAELEKR FANMLGEDVA
     SHYLDLNNPY MQSNIEYMKK QSTDYLALMG SPDELAPAAP RYVNGHIVPD IRIEELPDDY
     MEMSRDSDPD ACTAIFSPTR LEGESSDFPD FSSETTFNFP GARQSPTLSN NLNSGSSKPL
     RKKNGMPTVD VADQAPEEIP MLHRSSTGSD GSPEQGRRFN QALKQQYVTP TPSPRHHVET
     KLNGEPSENY VNMKPPRKNI PGKTTTGGGG AAAGASTEAF SNPSYQPLST VNEKEQRRY
//