ID Q7KPV0_CAEEL Unreviewed; 378 AA. AC Q7KPV0; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 16-JAN-2019, entry version 53. DE SubName: Full=G protein, Subunit Alpha {ECO:0000313|EMBL:CCD73235.2}; GN Name=gsa-1 {ECO:0000313|EMBL:CCD73235.2, GN ECO:0000313|WormBase:R06A10.2a}; GN ORFNames=CELE_R06A10.2 {ECO:0000313|EMBL:CCD73235.2}, R06A10.2 GN {ECO:0000313|WormBase:R06A10.2a}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73235.2, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|EMBL:CCD73235.2, ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73235.2, RC ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RA Sulson J.E., Waterston R.; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX284601; CCD73235.2; -; Genomic_DNA. DR PIR; D87723; D87723. DR PIR; T37243; T37245. DR RefSeq; NP_490817.4; NM_058416.5. DR ProteinModelPortal; Q7KPV0; -. DR SMR; Q7KPV0; -. DR STRING; 6239.R06A10.2.1; -. DR EPD; Q7KPV0; -. DR PaxDb; Q7KPV0; -. DR EnsemblMetazoa; R06A10.2a.1; R06A10.2a.1; WBGene00001745. DR EnsemblMetazoa; R06A10.2a.2; R06A10.2a.2; WBGene00001745. DR GeneID; 171687; -. DR KEGG; cel:CELE_R06A10.2; -. DR CTD; 171687; -. DR WormBase; R06A10.2a; CE47896; WBGene00001745; gsa-1. DR eggNOG; KOG0099; Eukaryota. DR eggNOG; ENOG410XPC4; LUCA. DR GeneTree; ENSGT00940000168108; -. DR InParanoid; Q7KPV0; -. DR KO; K04632; -. DR OMA; QENRATC; -. DR OrthoDB; 754573at2759; -. DR Reactome; R-CEL-163359; Glucagon signaling in metabolic regulation. DR Reactome; R-CEL-164378; PKA activation in glucagon signalling. DR Reactome; R-CEL-170660; Adenylate cyclase activating pathway. DR Reactome; R-CEL-170670; Adenylate cyclase inhibitory pathway. DR Reactome; R-CEL-418555; G alpha (s) signalling events. DR Reactome; R-CEL-432040; Vasopressin regulates renal water homeostasis via Aquaporins. DR Proteomes; UP000001940; Chromosome I. DR Bgee; WBGene00001745; Expressed in 3 organ(s), highest expression level in multi-cellular organism. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central. DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central. DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central. DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:GO_Central. DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0090038; P:negative regulation of protein kinase C signaling; IGI:WormBase. DR GO; GO:1900195; P:positive regulation of oocyte maturation; IMP:UniProtKB. DR GO; GO:2000292; P:regulation of defecation; IGI:UniProtKB. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IGI:WormBase. DR CDD; cd00066; G-alpha; 1. DR Gene3D; 1.10.400.10; -; 1. DR InterPro; IPR000367; Gprotein_alpha_S. DR InterPro; IPR001019; Gprotein_alpha_su. DR InterPro; IPR011025; GproteinA_insert. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR10218; PTHR10218; 1. DR Pfam; PF00503; G-alpha; 1. DR PRINTS; PR00318; GPROTEINA. DR PRINTS; PR00443; GPROTEINAS. DR SMART; SM00275; G_alpha; 1. DR SUPFAM; SSF47895; SSF47895; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW GTP-binding {ECO:0000256|SAAS:SAAS00059430}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00059456}; KW Proteomics identification {ECO:0000213|EPD:Q7KPV0, KW ECO:0000213|PeptideAtlas:Q7KPV0}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. SQ SEQUENCE 378 AA; 44413 MW; A75AE7370820EB9C CRC64; MRLMGCVGAG ADAEGREARK VNKQIEEQLA KDKQVMRATH RLLLLGAGES GKSTIVKQMR ILHINGFNEA EKREKITDIR RNVRDAMQVI LRAMDEIVPK VSLDDPSTAI SRDYILRITN DPEDNYPSEF YDHILTCWKD KGVMACYERS SEYQLIDCAQ YFLDKVDVVR QNNYDPSEQD ILRCRVMTTG IFETKFEVDK VRFHMFDVGG QRDERRKWIQ CFNDVTAIIF VCASSSYNLV LWEDNTQNRL RESLALFKNI WNNRWLKTIS VILFLNKQDL LSEKIKAKRY LLESFFPEFE GYNLPNDAVF DNQEDKDVVR AKYFIRGEFL RISTANSDGR HHCYPHFTCA VDTENIRRVF NDCRDIIQRI HLRQYELL //