ID Q7KPV0_CAEEL Unreviewed; 378 AA. AC Q7KPV0; DT 06-FEB-2013, integrated into UniProtKB/TrEMBL. DT 06-FEB-2013, sequence version 1. DT 26-NOV-2014, entry version 17. DE SubName: Full=Protein GSA-1, isoform a {ECO:0000313|EMBL:CCD73235.2}; GN Name=gsa-1 {ECO:0000313|EMBL:CCD73235.2, GN ECO:0000313|WormBase:R06A10.2a}; GN ORFNames=CELE_R06A10.2 {ECO:0000313|EMBL:CCD73235.2}, R06A10.2 GN {ECO:0000313|WormBase:R06A10.2a}; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73235.2, ECO:0000313|Proteomes:UP000001940}; RN [1] {ECO:0000313|Proteomes:UP000001940} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2 {ECO:0000313|Proteomes:UP000001940}; RX PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO081671; CCD73235.2; -; Genomic_DNA. DR PIR; D87723; D87723. DR PIR; T37243; T37245. DR RefSeq; NP_490817.4; NM_058416.5. DR UniGene; Cel.19686; -. DR ProteinModelPortal; Q7KPV0; -. DR SMR; Q7KPV0; 34-375. DR EnsemblMetazoa; R06A10.2.1; R06A10.2.1; WBGene00001745. DR EnsemblMetazoa; R06A10.2.2; R06A10.2.2; WBGene00001745. DR GeneID; 171687; -. DR KEGG; cel:CELE_R06A10.2; -. DR CTD; 171687; -. DR WormBase; R06A10.2a; CE47896; WBGene00001745; gsa-1. DR GeneTree; ENSGT00770000120503; -. DR InParanoid; Q7KPV0; -. DR KO; K04632; -. DR OMA; MACYERS; -. DR Reactome; REACT_104417; Adenylate cyclase inhibitory pathway. DR Reactome; REACT_235104; Vasopressin regulates renal water homeostasis via Aquaporins. DR Reactome; REACT_238208; G alpha (z) signalling events. DR Reactome; REACT_244831; PKA activation in glucagon signalling. DR Reactome; REACT_249220; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion. DR Reactome; REACT_255560; G alpha (s) signalling events. DR Reactome; REACT_257245; Glucagon signaling in metabolic regulation. DR Reactome; REACT_261412; G alpha (i) signalling events. DR Reactome; REACT_261750; Adenylate cyclase activating pathway. DR Reactome; REACT_270601; Hedgehog 'off' state. DR ExpressionAtlas; Q7KPV0; baseline and differential. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome. DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome. DR GO; GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0003924; F:GTPase activity; IBA:RefGenome. DR GO; GO:0004871; F:signal transducer activity; IBA:RefGenome. DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:RefGenome. DR GO; GO:0090038; P:negative regulation of protein kinase C signaling; IGI:WormBase. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IGI:WormBase. DR GO; GO:0007606; P:sensory perception of chemical stimulus; IBA:RefGenome. DR Gene3D; 1.10.400.10; -; 1. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR000367; Gprotein_alpha_S. DR InterPro; IPR001019; Gprotein_alpha_su. DR InterPro; IPR011025; GproteinA_insert. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR10218; PTHR10218; 1. DR Pfam; PF00503; G-alpha; 1. DR PRINTS; PR00318; GPROTEINA. DR PRINTS; PR00443; GPROTEINAS. DR SMART; SM00275; G_alpha; 1. DR SUPFAM; SSF47895; SSF47895; 1. DR SUPFAM; SSF52540; SSF52540; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000001940}; KW GTP-binding {ECO:0000256|SAAS:SAAS00126938}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS00126918}; KW Reference proteome {ECO:0000313|Proteomes:UP000001940}. SQ SEQUENCE 378 AA; 44413 MW; A75AE7370820EB9C CRC64; MRLMGCVGAG ADAEGREARK VNKQIEEQLA KDKQVMRATH RLLLLGAGES GKSTIVKQMR ILHINGFNEA EKREKITDIR RNVRDAMQVI LRAMDEIVPK VSLDDPSTAI SRDYILRITN DPEDNYPSEF YDHILTCWKD KGVMACYERS SEYQLIDCAQ YFLDKVDVVR QNNYDPSEQD ILRCRVMTTG IFETKFEVDK VRFHMFDVGG QRDERRKWIQ CFNDVTAIIF VCASSSYNLV LWEDNTQNRL RESLALFKNI WNNRWLKTIS VILFLNKQDL LSEKIKAKRY LLESFFPEFE GYNLPNDAVF DNQEDKDVVR AKYFIRGEFL RISTANSDGR HHCYPHFTCA VDTENIRRVF NDCRDIIQRI HLRQYELL //