ID Q7KNF5_DROME Unreviewed; 554 AA. AC Q7KNF5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 03-NOV-2009, entry version 52. DE SubName: Full=Suppressor of variegation 2-10, isoform A; DE SubName: Full=Zimp-A; GN Name=Su(var)2-10; Synonyms=zimp; ORFNames=Dmel_CG8068; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=99196989; PubMed=10095110; DOI=10.1016/S0378-1119(99)00033-5; RA Mohr S.E., Boswell R.E.; RT "Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential RT gene in Drosophila melanogaster."; RL Gene 229:109-116(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- SIMILARITY: Contains 1 SAP domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF114486; AAD29287.1; -; Genomic_DNA. DR EMBL; AE013599; AAF58984.1; -; Genomic_DNA. DR RefSeq; NP_523664.1; -. DR UniGene; Dm.7311; -. DR IntAct; Q7KNF5; 1. DR STRING; Q7KNF5; -. DR PRIDE; Q7KNF5; -. DR Ensembl; FBtr0088570; FBpp0087651; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088571; FBpp0087652; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088572; FBpp0087653; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088573; FBpp0087654; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088574; FBpp0087655; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088575; FBpp0087656; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088576; FBpp0087657; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088577; FBpp0087658; FBgn0003612; Drosophila melanogaster. DR Ensembl; FBtr0088578; FBpp0087659; FBgn0003612; Drosophila melanogaster. DR GeneID; 35927; -. DR KEGG; dme:Dmel_CG8068; -. DR UCSC; CG8068-RA; d. melanogaster. DR CTD; 35927; -. DR FlyBase; FBgn0003612; Su(var)2-10. DR NextBio; 795869; -. DR ArrayExpress; Q7KNF5; -. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005737; C:cytoplasm; TAS:FlyBase. DR GO; GO:0005652; C:nuclear lamina; IDA:FlyBase. DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase. DR GO; GO:0035012; C:polytene chromosome, telomeric region; IDA:FlyBase. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030261; P:chromosome condensation; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; TAS:FlyBase. DR GO; GO:0030097; P:hemopoiesis; TAS:FlyBase. DR GO; GO:0007446; P:imaginal disc growth; TAS:FlyBase. DR GO; GO:0046426; P:negative regulation of JAK-STAT cascade; NAS:FlyBase. DR GO; GO:0042176; P:regulation of protein catabolic process; TAS:FlyBase. DR InterPro; IPR003034; SAP_DNA_bd. DR InterPro; IPR004181; Znf_MIZ. DR Pfam; PF02037; SAP; 1. DR Pfam; PF02891; zf-MIZ; 1. DR SMART; SM00513; SAP; 1. DR PROSITE; PS50800; SAP; 1. DR PROSITE; PS51044; ZF_SP_RING; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 554 AA; 61692 MW; 8599FD263578B565 CRC64; MVQMLRVVEL QKILSFLNIS FAGRKTDLQS RILSFLRTNL ELLAPKVQEV YAQSVQEQNA TLQYIDPTRM YSHIQLPPTV QPNPVGLVGS GQGVQVPGGQ MNVVGGAPFL HTHSINSQLP IHPDVRLKKL AFYDVLGTLI KPSTLVPRNT QRVQEVPFYF TLTPQQATEI ASNRDIRNSS KVEHAIQVQL RFCLVETSCD QEDCFPPNVN VKVNNKLCQL PNVIPTNRPN VEPKRPPRPV NVTSNVKLSP TVTNTITVQW CPDYTRSYCL AVYLVKKLTS TQLLQRMKTK GVKPADYTRG LIKEKLTEDA DCEIATTMLK VSLNCPLGKM KMLLPCRAST CSHLQCFDAS LYLQMNERKP TWNCPVCDKP AIYDNLVIDG YFQEVLGSSL LKSDDTEIQL HQDGSWSTPG LRSETQILDT PSKPAQKVEV ISDDIELISD DAKPVKRDLS PAQDEQPTST SNSETVDLTL SDSDDDMPLA KRRPPAKQAV ASSTSNGSGG GQRAYTPAQQ PQQSGGNVFK KPQKAEELYK RVHLGVWLRP RKPKPESSRR PNVG //