ID Q7KNF5_DROME Unreviewed; 554 AA. AC Q7KNF5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 29-SEP-2021, entry version 158. DE SubName: Full=Suppressor of variegation 2-10, isoform A {ECO:0000313|EMBL:AAF58984.1}; DE SubName: Full=Zimp-A {ECO:0000313|EMBL:AAD29287.1}; GN Name=Su(var)2-10 {ECO:0000313|EMBL:AAF58984.1, GN ECO:0000313|FlyBase:FBgn0003612}; GN Synonyms=CLOT2057 {ECO:0000313|EMBL:AAF58984.1}, Dmel\CG8068 GN {ECO:0000313|EMBL:AAF58984.1}, DmPias {ECO:0000313|EMBL:AAF58984.1}, GN DPIAS {ECO:0000313|EMBL:AAF58984.1}, Dpias GN {ECO:0000313|EMBL:AAF58984.1}, dPIAS {ECO:0000313|EMBL:AAF58984.1}, GN dpias {ECO:0000313|EMBL:AAF58984.1}, i184 GN {ECO:0000313|EMBL:AAF58984.1}, l(2)03697 GN {ECO:0000313|EMBL:AAF58984.1}, PIAS {ECO:0000313|EMBL:AAF58984.1}, GN pias {ECO:0000313|EMBL:AAF58984.1}, Su(var)-10 GN {ECO:0000313|EMBL:AAF58984.1}, SU(VAR)2-10 GN {ECO:0000313|EMBL:AAF58984.1}, Su(Var)2-10 GN {ECO:0000313|EMBL:AAF58984.1}, Su-var(2)10 GN {ECO:0000313|EMBL:AAF58984.1}, Suvar(2)10 GN {ECO:0000313|EMBL:AAF58984.1}, ZIMP {ECO:0000313|EMBL:AAF58984.1}, GN zimp {ECO:0000313|EMBL:AAD29287.1}, ZimpA GN {ECO:0000313|EMBL:AAF58984.1}, ZimpB {ECO:0000313|EMBL:AAF58984.1}; GN ORFNames=CG8068 {ECO:0000313|EMBL:AAF58984.1, GN ECO:0000313|FlyBase:FBgn0003612}, Dmel_CG8068 GN {ECO:0000313|EMBL:AAF58984.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD29287.1}; RN [1] {ECO:0000313|EMBL:AAD29287.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10095110; DOI=10.1016/S0378-1119(99)00033-5; RA Mohr S.E., Boswell R.E.; RT "Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene RT in Drosophila melanogaster."; RL Gene 229:109-116(1999). RN [2] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [6] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [15] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- PATHWAY: Protein modification; protein sumoylation. CC {ECO:0000256|ARBA:ARBA00004718}. CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}. CC -!- SIMILARITY: Belongs to the PIAS family. CC {ECO:0000256|ARBA:ARBA00005383}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF114486; AAD29287.1; -; Genomic_DNA. DR EMBL; AE013599; AAF58984.1; -; Genomic_DNA. DR RefSeq; NP_523664.1; NM_078940.3. DR SMR; Q7KNF5; -. DR DNASU; 35927; -. DR EnsemblMetazoa; FBtr0088578; FBpp0087659; FBgn0003612. DR GeneID; 35927; -. DR UCSC; CG8068-RA; d. melanogaster. DR CTD; 35927; -. DR FlyBase; FBgn0003612; Su(var)2-10. DR VEuPathDB; VectorBase:FBgn0003612; -. DR GeneTree; ENSGT01030000234539; -. DR Reactome; R-DME-210671; Transcriptional repression by nuclear factors. DR UniPathway; UPA00886; -. DR BioGRID-ORCS; 35927; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 35927; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0003612; Expressed in embryo and 40 other tissues. DR ExpressionAtlas; Q7KNF5; baseline and differential. DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IBA:GO_Central. DR GO; GO:0061665; F:SUMO ligase activity; IBA:GO_Central. DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0051276; P:chromosome organization; TAS:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; HMP:FlyBase. DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:FlyBase. DR GO; GO:0007446; P:imaginal disc growth; TAS:FlyBase. DR GO; GO:0045089; P:positive regulation of innate immune response; HMP:FlyBase. DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 1.10.720.30; -; 1. DR Gene3D; 2.60.120.780; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR027226; PIAS1/PIAS3. DR InterPro; IPR023321; PINIT. DR InterPro; IPR038654; PINIT_sf. DR InterPro; IPR003034; SAP_dom. DR InterPro; IPR036361; SAP_dom_sf. DR InterPro; IPR004181; Znf_MIZ. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR10782:SF11; PTHR10782:SF11; 1. DR Pfam; PF14324; PINIT; 1. DR Pfam; PF02891; zf-MIZ; 1. DR SMART; SM00513; SAP; 1. DR SUPFAM; SSF68906; SSF68906; 1. DR PROSITE; PS51466; PINIT; 1. DR PROSITE; PS50800; SAP; 1. DR PROSITE; PS51044; ZF_SP_RING; 1. PE 1: Evidence at protein level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7KNF5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00452}. FT DOMAIN 2..36 FT /note="SAP" FT /evidence="ECO:0000259|PROSITE:PS50800" FT DOMAIN 113..278 FT /note="PINIT" FT /evidence="ECO:0000259|PROSITE:PS51466" FT DOMAIN 310..387 FT /note="SP-RING-type" FT /evidence="ECO:0000259|PROSITE:PS51044" FT REGION 402..525 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 535..554 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 402..422 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 429..450 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 452..468 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 488..519 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 554 AA; 61692 MW; 8599FD263578B565 CRC64; MVQMLRVVEL QKILSFLNIS FAGRKTDLQS RILSFLRTNL ELLAPKVQEV YAQSVQEQNA TLQYIDPTRM YSHIQLPPTV QPNPVGLVGS GQGVQVPGGQ MNVVGGAPFL HTHSINSQLP IHPDVRLKKL AFYDVLGTLI KPSTLVPRNT QRVQEVPFYF TLTPQQATEI ASNRDIRNSS KVEHAIQVQL RFCLVETSCD QEDCFPPNVN VKVNNKLCQL PNVIPTNRPN VEPKRPPRPV NVTSNVKLSP TVTNTITVQW CPDYTRSYCL AVYLVKKLTS TQLLQRMKTK GVKPADYTRG LIKEKLTEDA DCEIATTMLK VSLNCPLGKM KMLLPCRAST CSHLQCFDAS LYLQMNERKP TWNCPVCDKP AIYDNLVIDG YFQEVLGSSL LKSDDTEIQL HQDGSWSTPG LRSETQILDT PSKPAQKVEV ISDDIELISD DAKPVKRDLS PAQDEQPTST SNSETVDLTL SDSDDDMPLA KRRPPAKQAV ASSTSNGSGG GQRAYTPAQQ PQQSGGNVFK KPQKAEELYK RVHLGVWLRP RKPKPESSRR PNVG //