ID Q7KNF5_DROME Unreviewed; 554 AA. AC Q7KNF5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 10-OCT-2018, entry version 136. DE SubName: Full=Suppressor of variegation 2-10, isoform A {ECO:0000313|EMBL:AAF58984.1}; DE SubName: Full=Zimp-A {ECO:0000313|EMBL:AAD29287.1}; GN Name=Su(var)2-10 {ECO:0000313|EMBL:AAF58984.1, GN ECO:0000313|FlyBase:FBgn0003612}; GN Synonyms=zimp {ECO:0000313|EMBL:AAD29287.1}; GN ORFNames=CG8068 {ECO:0000313|FlyBase:FBgn0003612}, Dmel_CG8068 GN {ECO:0000313|EMBL:AAF58984.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD29287.1}; RN [1] {ECO:0000313|EMBL:AAD29287.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=10095110; DOI=10.1016/S0378-1119(99)00033-5; RA Mohr S.E., Boswell R.E.; RT "Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential RT gene in Drosophila melanogaster."; RL Gene 229:109-116(1999). RN [2] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [5] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [6] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [7] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF58984.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAF58984.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF114486; AAD29287.1; -; Genomic_DNA. DR EMBL; AE013599; AAF58984.1; -; Genomic_DNA. DR RefSeq; NP_523664.1; NM_078940.3. DR UniGene; Dm.7311; -. DR EnsemblMetazoa; FBtr0088578; FBpp0087659; FBgn0003612. DR GeneID; 35927; -. DR UCSC; CG8068-RA; d. melanogaster. DR CTD; 35927; -. DR FlyBase; FBgn0003612; Su(var)2-10. DR eggNOG; KOG2169; Eukaryota. DR eggNOG; ENOG410XQ2E; LUCA. DR GeneTree; ENSGT00550000074410; -. DR OrthoDB; EOG091G08G5; -. DR Reactome; R-DME-196791; Vitamin D (calciferol) metabolism. DR Reactome; R-DME-210671; Transcriptional repression by nuclear factors. DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins. DR Reactome; R-DME-3232118; SUMOylation of transcription factors. DR Reactome; R-DME-3899300; SUMOylation of transcription cofactors. DR Reactome; R-DME-4090294; SUMOylation of intracellular receptors. DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins. DR Reactome; R-DME-4755510; SUMOylation of immune response proteins. DR Reactome; R-DME-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. DR Reactome; R-DME-5693571; Nonhomologous End-Joining (NHEJ). DR Reactome; R-DME-5696395; Formation of Incision Complex in GG-NER. DR GenomeRNAi; 35927; -. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0003612; Expressed in 32 organ(s), highest expression level in egg cell. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005652; C:nuclear lamina; IDA:FlyBase. DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0005700; C:polytene chromosome; IDA:FlyBase. DR GO; GO:0035012; C:polytene chromosome, telomeric region; IDA:FlyBase. DR GO; GO:0003677; F:DNA binding; ISS:FlyBase. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030261; P:chromosome condensation; IMP:FlyBase. DR GO; GO:0051276; P:chromosome organization; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; HMP:FlyBase. DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:FlyBase. DR GO; GO:0030097; P:hemopoiesis; TAS:FlyBase. DR GO; GO:0007446; P:imaginal disc growth; TAS:FlyBase. DR GO; GO:0007259; P:JAK-STAT cascade; TAS:Reactome. DR GO; GO:0046426; P:negative regulation of JAK-STAT cascade; NAS:FlyBase. DR GO; GO:0045089; P:positive regulation of innate immune response; HMP:FlyBase. DR Gene3D; 1.10.720.30; -; 1. DR Gene3D; 2.60.120.780; -; 1. DR Gene3D; 3.30.40.10; -; 1. DR InterPro; IPR023321; PINIT. DR InterPro; IPR038654; PINIT_sf. DR InterPro; IPR003034; SAP_dom. DR InterPro; IPR036361; SAP_dom_sf. DR InterPro; IPR004181; Znf_MIZ. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR Pfam; PF14324; PINIT; 1. DR Pfam; PF02037; SAP; 1. DR Pfam; PF02891; zf-MIZ; 1. DR SMART; SM00513; SAP; 1. DR SUPFAM; SSF68906; SSF68906; 1. DR PROSITE; PS51466; PINIT; 1. DR PROSITE; PS50800; SAP; 1. DR PROSITE; PS51044; ZF_SP_RING; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00452}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q7KNF5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00452}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00452}. FT DOMAIN 2 36 SAP. {ECO:0000259|PROSITE:PS50800}. FT DOMAIN 113 278 PINIT. {ECO:0000259|PROSITE:PS51466}. FT DOMAIN 310 387 SP-RING-type. {ECO:0000259|PROSITE: FT PS51044}. FT ZN_FING 310 387 SP-RING-type. {ECO:0000256|PROSITE- FT ProRule:PRU00452}. SQ SEQUENCE 554 AA; 61692 MW; 8599FD263578B565 CRC64; MVQMLRVVEL QKILSFLNIS FAGRKTDLQS RILSFLRTNL ELLAPKVQEV YAQSVQEQNA TLQYIDPTRM YSHIQLPPTV QPNPVGLVGS GQGVQVPGGQ MNVVGGAPFL HTHSINSQLP IHPDVRLKKL AFYDVLGTLI KPSTLVPRNT QRVQEVPFYF TLTPQQATEI ASNRDIRNSS KVEHAIQVQL RFCLVETSCD QEDCFPPNVN VKVNNKLCQL PNVIPTNRPN VEPKRPPRPV NVTSNVKLSP TVTNTITVQW CPDYTRSYCL AVYLVKKLTS TQLLQRMKTK GVKPADYTRG LIKEKLTEDA DCEIATTMLK VSLNCPLGKM KMLLPCRAST CSHLQCFDAS LYLQMNERKP TWNCPVCDKP AIYDNLVIDG YFQEVLGSSL LKSDDTEIQL HQDGSWSTPG LRSETQILDT PSKPAQKVEV ISDDIELISD DAKPVKRDLS PAQDEQPTST SNSETVDLTL SDSDDDMPLA KRRPPAKQAV ASSTSNGSGG GQRAYTPAQQ PQQSGGNVFK KPQKAEELYK RVHLGVWLRP RKPKPESSRR PNVG //