ID Q79758_9HIV1 Unreviewed; 206 AA. AC Q79758; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 18-JUL-2018, entry version 83. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051655}; GN Name=nef {ECO:0000313|EMBL:AAA44979.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAA44979.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AAA44979.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=1985198; RA Delassus S., Cheynier R., Wain-Hobson S.; RT "Evolution of human immunodeficiency virus type 1 nef and long RT terminal repeat sequences over 4 years in vivo and in vitro."; RL J. Virol. 65:225-231(1991). CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS01051624}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01051622}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS01051622}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS01051622}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS01051605}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M58281; AAA44979.1; -; Genomic_RNA. DR ProteinModelPortal; Q79758; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-UniRule. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR GO; GO:0039504; P:suppression by virus of host adaptive immune response; IEA:UniProtKB-UniRule. DR GO; GO:0046776; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-UniRule. DR GO; GO:0039505; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II; IEA:UniProtKB-UniRule. DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR HAMAP; MF_04078; NEF_HIV; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor_sf. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS01051610}; KW Host membrane {ECO:0000256|SAAS:SAAS01051635}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01051595}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS01051602}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 206 AA; 23524 MW; 679A5C3C34CA2B02 CRC64; MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV LVWKFDSSLT FHHKARELHP EYYKDC //