ID   Q79758_9HIV1            Unreviewed;       206 AA.
AC   Q79758;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   18-JUL-2018, entry version 83.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051655};
GN   Name=nef {ECO:0000313|EMBL:AAA44979.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAA44979.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAA44979.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1985198;
RA   Delassus S., Cheynier R., Wain-Hobson S.;
RT   "Evolution of human immunodeficiency virus type 1 nef and long
RT   terminal repeat sequences over 4 years in vivo and in vitro.";
RL   J. Virol. 65:225-231(1991).
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS01051624}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane
CC       {ECO:0000256|SAAS:SAAS01051622}; Lipid-anchor
CC       {ECO:0000256|SAAS:SAAS01051622}; Cytoplasmic side
CC       {ECO:0000256|SAAS:SAAS01051622}.
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein
CC       family. {ECO:0000256|RuleBase:RU000344,
CC       ECO:0000256|SAAS:SAAS01051605}.
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DR   EMBL; M58281; AAA44979.1; -; Genomic_RNA.
DR   ProteinModelPortal; Q79758; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0039504; P:suppression by virus of host adaptive immune response; IEA:UniProtKB-UniRule.
DR   GO; GO:0046776; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-UniRule.
DR   GO; GO:0039505; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II; IEA:UniProtKB-UniRule.
DR   GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.62.10; -; 1.
DR   Gene3D; 4.10.890.10; -; 1.
DR   HAMAP; MF_04078; NEF_HIV; 1.
DR   InterPro; IPR027480; HIV-1_Nef_anchor_sf.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host cell membrane {ECO:0000256|SAAS:SAAS01051610};
KW   Host membrane {ECO:0000256|SAAS:SAAS01051635};
KW   Host-virus interaction {ECO:0000256|SAAS:SAAS01051595};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Membrane {ECO:0000256|SAAS:SAAS01051602};
KW   Myristate {ECO:0000256|RuleBase:RU000344};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|RuleBase:RU000344}.
SQ   SEQUENCE   206 AA;  23524 MW;  679A5C3C34CA2B02 CRC64;
     MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA
     QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY
     FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV
     LVWKFDSSLT FHHKARELHP EYYKDC
//