ID   Q79758_9HIV1            Unreviewed;       206 AA.
AC   Q79758;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   28-JUN-2011, entry version 57.
DE   RecName: Full=Protein Nef;
GN   Name=nef;
OS   Human immunodeficiency virus 1.
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Lentivirus; Primate lentivirus group.
OX   NCBI_TaxID=11676;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=91087286; PubMed=1985198;
RA   Delassus S., Cheynier R., Wain-Hobson S.;
RT   "Evolution of human immunodeficiency virus type 1 nef and long
RT   terminal repeat sequences over 4 years in vivo and in vitro.";
RL   J. Virol. 65:225-231(1991).
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein
CC       family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M58281; AAA44979.1; -; Genomic_RNA.
DR   HSSP; Q70627; 2NEF.
DR   ProteinModelPortal; Q79758; -.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR001558; HIV_Nef.
DR   Gene3D; G3DSA:3.30.62.10; HIV_Nef; 1.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; HIV_Nef; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host membrane; Host-virus interaction;
KW   Lipoprotein; Membrane; Myristate; Viral immunoevasion; Virulence.
SQ   SEQUENCE   206 AA;  23524 MW;  679A5C3C34CA2B02 CRC64;
     MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA
     QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY
     FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV
     LVWKFDSSLT FHHKARELHP EYYKDC
//