ID Q79758_9HIV1 Unreviewed; 206 AA. AC Q79758; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 28-JUN-2011, entry version 57. DE RecName: Full=Protein Nef; GN Name=nef; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=91087286; PubMed=1985198; RA Delassus S., Cheynier R., Wain-Hobson S.; RT "Evolution of human immunodeficiency virus type 1 nef and long RT terminal repeat sequences over 4 years in vivo and in vitro."; RL J. Virol. 65:225-231(1991). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M58281; AAA44979.1; -; Genomic_RNA. DR HSSP; Q70627; 2NEF. DR ProteinModelPortal; Q79758; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR InterPro; IPR001558; HIV_Nef. DR Gene3D; G3DSA:3.30.62.10; HIV_Nef; 1. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; HIV_Nef; 1. PE 3: Inferred from homology; KW Host cell membrane; Host membrane; Host-virus interaction; KW Lipoprotein; Membrane; Myristate; Viral immunoevasion; Virulence. SQ SEQUENCE 206 AA; 23524 MW; 679A5C3C34CA2B02 CRC64; MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV LVWKFDSSLT FHHKARELHP EYYKDC //