ID   Q79758      PRELIMINARY;      PRT;   206 AA.
AC   Q79758;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT   01-OCT-2002 (TrEMBLrel. 22, Last annotation update)
DE   Nef protein (Negative factor) (27 kDa protein).
GN   NEF.
OS   Human immunodeficiency virus 1.
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11676;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91087286; PubMed=1985198;
RA   Delassus S., Cheynier R., Wain-Hobson S.;
RT   "Evolution of human immunodeficiency virus type 1 nef and long
RT   terminal repeat sequences over 4 year in vivo and in vitro.";
RL   J. Virol. 65:225-231(1991).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES. IT SEEMS TO DOWN-REGULATE THE CD4(T4) ANTIGEN (BY
CC       SIMILARITY).
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DR   EMBL; M58281; AAA44979.1; -.
DR   HSSP; P03406; 1EFN.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   ProDom; PD000031; HIV_Nef; 1.
KW   AIDS; GTP-binding; Lipoprotein; Myristate.
SQ   SEQUENCE   206 AA;  23524 MW;  679A5C3C34CA2B02 CRC64;
     MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA
     QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY
     FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV
     LVWKFDSSLT FHHKARELHP EYYKDC
//