ID Q79758 PRELIMINARY; PRT; 206 AA. AC Q79758; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-JUN-2002 (TrEMBLrel. 21, Last annotation update) DE Negative factor (F-protein) (27 kDa protein). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91087286; PubMed=1985198; RA Delassus S., Cheynier R., Wain-Hobson S.; RT "Evolution of human immunodeficiency virus type 1 nef and long RT terminal repeat sequences over 4 year in vivo and in vitro."; RL J. Virol. 65:225-231(1991). CC -!- SIMILARITY: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN-REGULATE THE CD4(T4) ANTIGEN. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M58281; AAA44979.1; -. DR HSSP; P03406; 1EFN. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; HIV_Nef; 1. KW AIDS; GTP-binding; Myristate. SQ SEQUENCE 206 AA; 23524 MW; 679A5C3C34CA2B02 CRC64; MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV LVWKFDSSLT FHHKARELHP EYYKDC //