ID Q79758 PRELIMINARY; PRT; 206 AA. AC Q79758; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-JUN-2001 (TrEMBLrel. 17, Last annotation update) DE NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN). GN NEF. OS Human immunodeficiency virus type 1. OC Viruses; Retroid viruses; Retroviridae; Lentivirus. OX NCBI_TaxID=11676; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=91087286; PubMed=1985198; RA Delassus S., Cheynier R., Wain-Hobson S.; RT "Evolution of human immunodeficiency virus type 1 nef and long RT terminal repeat sequences over 4 years in vivo and in vitro."; RL J. Virol. 65:225-231(1991). CC -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING CC ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF CC PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS CC INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION CC AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY CC TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M58281; AAA44979.1; -. DR HSSP; Q70627; 2NEF. DR InterPro; IPR001558; F-protein. DR Pfam; PF00469; F-protein; 1. KW AIDS; GTP-binding; Myristate. SQ SEQUENCE 206 AA; 23524 MW; 679A5C3C34CA2B02 CRC64; MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV LVWKFDSSLT FHHKARELHP EYYKDC //