ID   Q79758      PRELIMINARY;      PRT;   206 AA.
AC   Q79758;
DT   01-NOV-1996 (TrEMBLrel. 01, Created)
DT   01-NOV-1996 (TrEMBLrel. 01, Last sequence update)
DT   01-JUN-2001 (TrEMBLrel. 17, Last annotation update)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KDA PROTEIN).
GN   NEF.
OS   Human immunodeficiency virus type 1.
OC   Viruses; Retroid viruses; Retroviridae; Lentivirus.
OX   NCBI_TaxID=11676;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91087286; PubMed=1985198;
RA   Delassus S., Cheynier R., Wain-Hobson S.;
RT   "Evolution of human immunodeficiency virus type 1 nef and long
RT   terminal repeat sequences over 4 years in vivo and in vitro.";
RL   J. Virol. 65:225-231(1991).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEMS TO DOWN REGULATE THE CD4(T4) ANTIGEN. NEF
CC       PROTEIN ACCELERATES VIRULENT PROGRESSION OF AIDS BY ITS
CC       INTERACTION WITH CELLULAR PROTEINS INVOLVED IN SIGNAL TRANSDUCTION
CC       AND HOST CELL ACTIVATION. NEF HAS BEEN SHOWN TO BIND SPECIFICALLY
CC       TO A SUBSET OF THE SRC KINASE FAMILY (BY SIMILARITY).
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DR   EMBL; M58281; AAA44979.1; -.
DR   HSSP; Q70627; 2NEF.
DR   InterPro; IPR001558; F-protein.
DR   Pfam; PF00469; F-protein; 1.
KW   AIDS; GTP-binding; Myristate.
SQ   SEQUENCE   206 AA;  23524 MW;  679A5C3C34CA2B02 CRC64;
     MGGKWSKNSM SGWTTIRERM RQAEPAADGV GAVSRDLEKH GAITSSNTAA TNADCAWLEA
     QEEEEVGFPV RPQVPLRPMT RRAAIDLSHF LREKGGLEGL VHSQKRQEIL DLWVYHTQGY
     FPDWQNYTPG PGIRWPLTLG WCFKLVPVEP EQVEEANEGE NNSLLHPMSQ HGMEDPEKEV
     LVWKFDSSLT FHHKARELHP EYYKDC
//