ID Q77YB1_HRSVA Unreviewed; 64 AA. AC Q77YB1; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 86. DE RecName: Full=Small hydrophobic protein {ECO:0000256|ARBA:ARBA00017613}; DE AltName: Full=Small protein 1A {ECO:0000256|ARBA:ARBA00031803}; GN Name=SH (1A) {ECO:0000313|EMBL:AAC14900.1}; OS Human respiratory syncytial virus A (strain A2). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus; OC Orthopneumovirus hominis. OX NCBI_TaxID=11259 {ECO:0000313|EMBL:AAC14900.1, ECO:0000313|Proteomes:UP000181559}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AAC14900.1, ECO:0000313|Proteomes:UP000181559} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=mutant rA2cp {ECO:0000313|Proteomes:UP000181559}; RX PubMed=9557743; RA Whitehead S.S., Juhasz K., Firestone C.Y., Collins P.L., Murphy B.R.; RT "Recombinant respiratory syncytial virus (RSV) bearing a set of mutations RT from cold-passaged RSV is attenuated in chimpanzees."; RL J. Virol. 72:4467-4471(1998). CC -!- INTERACTION: CC Q77YB1; P51572: BCAP31; Xeno; NbExp=6; IntAct=EBI-11358177, EBI-77683; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}. CC Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648}; Single- CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648}. Host CC Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00024014}; Single-pass CC type II membrane protein {ECO:0000256|ARBA:ARBA00024014}. Host cell CC membrane {ECO:0000256|ARBA:ARBA00004336}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00004336}. Host endoplasmic reticulum CC membrane {ECO:0000256|ARBA:ARBA00004641}; Single-pass type II membrane CC protein {ECO:0000256|ARBA:ARBA00004641}. CC -!- SIMILARITY: Belongs to the orthopneumovirus small hydrophobic protein CC family. {ECO:0000256|ARBA:ARBA00024027}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF035006; AAC14900.1; -; Genomic_RNA. DR SMR; Q77YB1; -. DR IntAct; Q77YB1; 5. DR Proteomes; UP000181559; Genome. DR GO; GO:0044165; C:host cell endoplasmic reticulum; IMP:AgBase. DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0019051; P:induction by virus of host apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW. DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW. DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW. DR InterPro; IPR005327; SHP. DR Pfam; PF03579; SHP; 1. PE 1: Evidence at protein level; KW Activation of host caspases by virus {ECO:0000256|ARBA:ARBA00035732}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023039}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00023039}; KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039}. FT TRANSMEM 20..41 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 64 AA; 7536 MW; 02C92E27F227E66B CRC64; MENTSITIEF SSKFWPYFTL IHMITTIISL LIIISIMIAI LNKLCEYNVF HNKTFELPRA RVNT //