ID Q77MD4_9INFA Unreviewed; 97 AA. AC Q77MD4; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 05-OCT-2010, entry version 26. DE SubName: Full=Membrane ion channel M2; GN Name=M; OS Influenza A virus (A/Hong Kong/488/97(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=155222; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Hong Kong/488/97; RX MEDLINE=21615254; PubMed=11748666; DOI=10.1002/jmv.2118; RA Shaw M., Cooper L., Xu X., Thompson W., Krauss S., Guan Y., Zhou N., RA Klimov A., Cox N., Webster R., Lim W., Shortridge K., Subbarao K.; RT "Molecular changes associated with the transmission of avian influenza RT a H5N1 and H9N2 viruses to humans."; RL J. Med. Virol. 66:107-114(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Hong Kong/488/97; RA Shaw M.W., Cooper L.A., Xu X., Thompson W.W., Krauss S.L., Guan Y., RA Zhou N.N., Klimov A., Cox N.J., Webster R.G., Lim W., Shortridge K.F., RA Subbarao K.; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms a proton-selective ion channel that is necessary CC for the efficient release of the viral genome during virus entry. CC After attaching to the cell surface, the virion enters the cell by CC endocytosis. Acidification of the endosome triggers M2 ion channel CC activity. The influx of protons into virion interior is believed CC to disrupt interactions between the viral ribonucleoprotein (RNP), CC matrix protein 1 (M1), and lipid bilayers, thereby freeing the CC viral genome from interaction with viral proteins and enabling RNA CC segments to migrate to the host cell nucleus, where influenza CC virus RNA transcription and replication occur. Also plays a role CC in viral proteins secretory pathway. Elevates the intravesicular CC pH of normally acidic compartments, such as trans-Golgi network, CC preventing newly formed hemagglutinin from premature switching to CC the fusion-active conformation (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF255378; AAK49257.1; -; Genomic_RNA. DR EMBL; AF255377; AAK49257.1; JOINED; Genomic_RNA. DR ProteinModelPortal; Q77MD4; -. DR SMR; Q77MD4; 23-60. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter acti...; IEA:InterPro. DR GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. DR ProDom; PD001031; Flu_M2; 1. PE 3: Inferred from homology; KW Host cell membrane; Host membrane; Hydrogen ion transport; KW Ion transport; Ionic channel; Membrane; Transmembrane; KW Transmembrane helix; Transport; Virion. SQ SEQUENCE 97 AA; 11203 MW; F4C22FD462FF0BF9 CRC64; MSLLTEVETL TRNGWGCRCS DSSDPLVVAA SIIGILHLIL WILDRLFFKC IYRRFKYGLK RGPPTEGVLE SMREEYRQEQ QNAVDVDDGH FVNIELE //