ID Q773G3_PRRSV Unreviewed; 123 AA. AC Q773G3; DT 23-MAY-2018, integrated into UniProtKB/TrEMBL. DT 23-MAY-2018, sequence version 1. DT 29-MAY-2024, entry version 41. DE RecName: Full=Nucleoprotein {ECO:0000256|ARBA:ARBA00014389}; DE AltName: Full=Nucleocapsid protein {ECO:0000256|ARBA:ARBA00033344}; GN Name=ORF7 {ECO:0000313|EMBL:AAU20782.1}; GN Synonyms=N {ECO:0000313|EMBL:ABO40170.1}; OS Porcine reproductive and respiratory syndrome virus (PRRSV). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Arnidovirineae; Arteriviridae; Variarterivirinae; OC Betaarterivirus; Ampobartevirus; Betaarterivirus suid 2. OX NCBI_TaxID=28344 {ECO:0000313|EMBL:AAO13198.1, ECO:0000313|Proteomes:UP000164333}; OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:AAA85827.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ISU-1894 {ECO:0000313|EMBL:AAA85827.1}; RA Meng X.-J.; RL Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAA85827.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ISU-1894 {ECO:0000313|EMBL:AAA85827.1}; RX PubMed=7794115; DOI=10.1007/BF01309962; RA Meng X.J., Paul P.S., Halbur P.G., Lum M.A.; RT "Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of RT porcine reproductive and respiratory syndrome virus (PRRSV): implication RT for the existence of two genotypes of PRRSV in the U.S.A. and Europe."; RL Arch. Virol. 140:745-755(1995). RN [3] {ECO:0000313|EMBL:CAA11090.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Danish DK3506-12 {ECO:0000313|EMBL:CAA11090.1}; RX PubMed=9787654; DOI=10.1007/s007050050409; RA Madsen K.G., Hansen C.M., Madsen E.S., Strandbygaard B., Boetner A., RA Soerensen K.J.; RT "Sequence analysis of porcine reproductive and respiratory syndrome virus RT of the American type collected from Danish swine herds."; RL Arch. Virol. 143:1683-1700(1998). RN [4] {ECO:0000313|EMBL:AAC64115.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=S1 {ECO:0000313|EMBL:AAC64115.1}; RA Jiang P., Chen P.Y., Jiang Z.H., Cai B.X., Cai J.L., Tong Y.Y.; RT "Characteristic of Open Reading Frame 5, 6 and 7 Genes of Porcine RT Reproductive and Respiratory Syndrome Virus (S1) isolated in P.R. China."; RL Zhongguo Yu Fang Shou Yi Xue Bao 0:0-0(1998). RN [5] {ECO:0000313|EMBL:AAC64115.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=S1 {ECO:0000313|EMBL:AAC64115.1}; RA Jiang P., Chen P.Y., Jiang Z.H., Cai B.X., Cai J.L., Tong Y.Y.; RT "Comparison of ORF5 Gene of Two isolates of Porcine Reproductive and RT Respiratory Syndrome Virus from Different Regions of P.R. China."; RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAC36680.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOBL vaccine strain {ECO:0000313|EMBL:AAC36680.1}; RX PubMed=10226618; DOI=10.1007/s007050050523; RA Yang L., Yoon K.J., Li Y., Lee J.H., Zimmerman J.J., Frey M.L., RA Harmon K.M., Platt K.B.; RT "Antigenic and genetic variations of the 15 kD nucleocapsid protein of RT porcine reproductive and respiratory syndrome virus isolates."; RL Arch. Virol. 144:525-546(1999). RN [7] {ECO:0000313|EMBL:AAD37049.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Vac {ECO:0000313|EMBL:AAD37049.1}; RX PubMed=10664392; DOI=10.1007/s007050050652; RA Storgaard T., Oleksiewicz M., Botner A.; RT "Examination of the selective pressures on a live PRRS vaccine virus."; RL Arch. Virol. 144:2389-2401(1999). RN [8] {ECO:0000313|EMBL:AAG02140.1, ECO:0000313|Proteomes:UP000115075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MLV RespPRRS/Repro {ECO:0000313|EMBL:AAG02140.1}; RX PubMed=10948988; DOI=10.1007/s007050070115; RA Allende R., Kutish G.F., Laegreid W., Lu Z., Lewis T.L., Rock D.L., RA Friesen J., Galeota J.A., Doster A.R., Osorio F.A.; RT "Mutations in the genome of porcine reproductive and respiratory syndrome RT virus responsible for the attenuation phenotype."; RL Arch. Virol. 145:1149-1161(2000). RN [9] {ECO:0000313|EMBL:AAG13733.1, ECO:0000313|Proteomes:UP000149815} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PA8 {ECO:0000313|EMBL:AAG13733.1}; RX PubMed=11205119; DOI=10.1007/s007050070022; RA Wootton S., Yoo D., Rogan D.; RT "Full-length sequence of a Canadian porcine reproductive and respiratory RT syndrome virus (PRRSV) isolate."; RL Arch. Virol. 145:2297-2323(2000). RN [10] {ECO:0000313|EMBL:AAK20467.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=16244B {ECO:0000313|EMBL:AAK20467.1}; RX PubMed=11044133; DOI=10.1128/JVI.74.22.10834-10837.2000; RA Allende R., Laegreid W.W., Kutish G.F., Galeota J.A., Wills R.W., RA Osorio F.A.; RT "Porcine reproductive and respiratory syndrome virus: description of RT persistence in individual pigs upon experimental infection."; RL J. Virol. 74:10834-10837(2000). RN [11] {ECO:0000313|EMBL:AAG49626.1, ECO:0000313|Proteomes:UP000148928} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BJ-4 {ECO:0000313|EMBL:AAG49626.1}; RA Yang H., Huang F., Guo X., Gao Y., Li H., Chen S.; RT "Sequencing the Genome of Porcine Reproductive and Respiratory Syndrome RT Virus Isolate BJ-4."; RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAG13733.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PA8 {ECO:0000313|EMBL:AAG13733.1}; RA Wootton S.K., Yoo D.; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:AAO13198.1, ECO:0000313|Proteomes:UP000164333} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VR-2332 {ECO:0000313|EMBL:AAO13198.1}; RX PubMed=12610145; DOI=10.1128/JVI.77.6.3702-3711.2003; RA Nielsen H.S., Liu G., Nielsen J., Oleksiewicz M.B., Botner A., RA Storgaard T., Faaberg K.S.; RT "Generation of an infectious clone of VR-2332, a highly virulent North RT American-type isolate of porcine reproductive and respiratory syndrome RT virus."; RL J. Virol. 77:3702-3711(2003). RN [14] {ECO:0000313|EMBL:AAS78207.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1530B {ECO:0000313|EMBL:AAS78207.1}; RX PubMed=15507307; DOI=10.1016/j.vetimm.2004.09.009; RA Lee S.M., Schommer S.K., Kleiboeker S.B.; RT "Porcine reproductive and respiratory syndrome virus field isolates differ RT in in vitro interferon phenotypes."; RL Vet. Immunol. Immunopathol. 102:217-231(2004). RN [15] {ECO:0000313|Proteomes:UP000104281, ECO:0000313|Proteomes:UP000115425} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PL97-1 {ECO:0000313|EMBL:AAT00230.1}, and PL97-1/LP1 RC {ECO:0000313|EMBL:AAU20782.1}; RX PubMed=15246654; DOI=10.1016/j.virusres.2004.04.003; RA Kang S.Y., Yun S.I., Park H.S., Park C.K., Choi H.S., Lee Y.M.; RT "Molecular characterization of PL97-1, the first Korean isolate of the RT porcine reproductive and respiratory syndrome virus."; RL Virus Res. 104:165-179(2004). RN [16] {ECO:0000313|EMBL:AAP81809.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=VR-2332 {ECO:0000313|EMBL:AAP81809.1}; RX PubMed=15325083; DOI=10.1016/j.virusres.2004.04.015; RA Yuan S., Murtaugh M.P., Schumann F.A., Mickelson D., Faaberg K.S.; RT "Characterization of heteroclite subgenomic RNAs associated with PRRSV RT infection."; RL Virus Res. 105:75-87(2004). RN [17] {ECO:0000313|EMBL:AAT00230.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PL97-1 {ECO:0000313|EMBL:AAT00230.1}; RA Kang S.-Y., Yun S.-I., Park H.-S., Park C.-K., Choi H.-S., Lee Y.-M.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:AAU20782.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PL97-1/LP1 {ECO:0000313|EMBL:AAU20782.1}; RA Choi Y.-J., Yun S.-I., Kang S.-Y., Choi H.-S., Lee Y.-M.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [19] {ECO:0000313|EMBL:AAY53878.1, ECO:0000313|Proteomes:UP000140239} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=01NP1.2 {ECO:0000313|EMBL:AAY53878.1}; RA Amonsin A., Pariyothorn N., Puranaveja S., Koowattananukul C., RA Wongyanin P., Suradhat S., Thanawongnuwech R.; RT "Full-length sequence of a Thai porcine reproductive and respiratory RT syndrome virus (PRRSV) isolate."; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [20] {ECO:0000313|EMBL:AAD27658.1, ECO:0000313|Proteomes:UP000173839} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RespPRRS vaccine {ECO:0000313|EMBL:AAD27658.1}; RA Nelsen C.J., Regan K., Faaberg K.S., Murtaugh M.P.; RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. RN [21] {ECO:0000313|EMBL:ABB18280.1, ECO:0000313|Proteomes:UP000147722} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Liu G., Han J., Liu H., Wang Y., Roof M.B., Vaughn E.M., Burkhart K.M., RA Faaberg K.S.; RT "Infectious Clone of Porcine Reproductive and Respiratory Syndrome Virus RT Type 2 Strain VR-2332."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [22] {ECO:0000313|EMBL:AAU20782.1, ECO:0000313|Proteomes:UP000104281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PL97-1/LP1 {ECO:0000313|EMBL:AAU20782.1}; RX PubMed=16378975; DOI=10.1128/JVI.80.2.723-736.2006; RA Choi Y.J., Yun S.I., Kang S.Y., Lee Y.M.; RT "Identification of 5' and 3' cis-acting elements of the porcine RT reproductive and respiratory syndrome virus: acquisition of novel 5' AU- RT rich sequences restored replication of a 5'-proximal 7-nucleotide deletion RT mutant."; RL J. Virol. 80:723-736(2006). RN [23] {ECO:0000313|EMBL:ABB29771.1, ECO:0000313|Proteomes:UP000126860} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VR-2332 {ECO:0000313|EMBL:ABB29771.1}; RX PubMed=17522233; DOI=10.1128/JVI.00562-07; RA Han J., Liu G., Wang Y., Faaberg K.S.; RT "Identification of nonessential regions of the nsp2 replicase protein of RT porcine reproductive and respiratory syndrome virus strain VR-2332 for RT replication in cell culture."; RL J. Virol. 81:9878-9890(2007). RN [24] {ECO:0000313|EMBL:ABO40170.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=VR-2332 {ECO:0000313|EMBL:ABO40170.1}; RX PubMed=17467931; DOI=10.1016/j.vetmic.2007.03.007; RA Kim W.I., Lee D.S., Johnson W., Roof M., Cha S.H., Yoon K.J.; RT "Effect of genotypic and biotypic differences among PRRS viruses on the RT serologic assessment of pigs for virus infection."; RL Vet. Microbiol. 123:1-14(2007). RN [25] {ECO:0000313|EMBL:ABE73144.1, ECO:0000313|Proteomes:UP000128580} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S1 {ECO:0000313|EMBL:ABE73144.1}; RX PubMed=17671836; DOI=10.1007/s11262-007-0134-8; RA Li G., Huang J., Jiang P., Li Y., Jiang W., Wang X.; RT "Suppression of porcine reproductive and respiratory syndrome virus RT replication in MARC-145 cells by shRNA targeting ORF1 region."; RL Virus Genes 35:673-679(2007). RN [26] {ECO:0000313|EMBL:ABO40170.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=VR-2332 {ECO:0000313|EMBL:ABO40170.1}; RA Kim W.-I., Lee D.-S., Johnson W., Roof M., Cha S.-H., Yoon K.-J.; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. RN [27] {ECO:0000313|EMBL:ABR23539.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=03KKGD7O7 {ECO:0000313|EMBL:ABR23539.1}; RA Yoon S.-H., Choi E.-J., Lee C.-H., Kim B.-H., Song J.-Y.; RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases. RN [28] {ECO:0000313|EMBL:ABU87648.1, ECO:0000313|Proteomes:UP000162391} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=QUAL1_Before {ECO:0000313|EMBL:ABU87648.1}; RA Murtaugh M.P., Abrahante J.E.; RT "Mechanisms of failed protection against PRRS in sow herds."; RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. RN [29] {ECO:0000313|EMBL:ABY66098.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RV63 {ECO:0000313|EMBL:ABY66107.1}, and RV68 RC {ECO:0000313|EMBL:ABY66098.1}; RA Ran Z., Chen X., Guo X., Ge X., Yoon K., Yang H.; RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. RN [30] {ECO:0000313|EMBL:ABR23539.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=03KKGD7O7 {ECO:0000313|EMBL:ABR23539.1}; RX PubMed=18227969; DOI=10.1007/s00705-007-0027-0; RA Yoon S.H., Song J.-Y., Lee C.-H., Choi E.-J., Cho I.S., Kim B.; RT "Genetic characterization of the Korean porcine reproductive and RT respiratory syndrome viruses based on the nucleocapsid protein gene (ORF7) RT sequences."; RL Arch. Virol. 153:627-635(2008). RN [31] {ECO:0000313|Proteomes:UP000105699, ECO:0000313|Proteomes:UP000159672} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RV63 {ECO:0000313|EMBL:ABY66107.1}, and RV68 RC {ECO:0000313|EMBL:ABY66098.1}; RX PubMed=18357408; DOI=10.1007/s00705-008-0064-3; RA Ran Z.G., Chen X.Y., Guo X., Ge X.N., Yoon K.J., Yang H.C.; RT "Recovery of viable porcine reproductive and respiratory syndrome virus RT from an infectious clone containing a partial deletion within the Nsp2- RT encoding region."; RL Arch. Virol. 153:899-907(2008). RN [32] {ECO:0000313|EMBL:ACJ71774.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CA {ECO:0000313|EMBL:ACJ71774.1}; RX PubMed=19107402; DOI=10.1007/s12275-008-0224-x; RA Koo H.N., Oh J.M., Lee J.K., Choi J.Y., Lee K.S., Roh J.Y., Je Y.H., RA Jin B.R., Yoo S.S., Kim J.S., Kim Y.I., Yoon I.J., Woo S.D.; RT "Molecular characterization of ORFs 2 to 7 of Korean porcine reproductive RT and respiratory syndrome virus (CA) and its protein expression by RT recombinant baculoviruses."; RL J. Microbiol. 46:709-719(2008). RN [33] {ECO:0000313|EMBL:ABO87448.1, ECO:0000313|Proteomes:UP000163702} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Ingelvac MLV {ECO:0000313|EMBL:ABO87448.1}; RX PubMed=17976680; DOI=10.1016/j.virol.2007.09.032; RA Wang Y., Liang Y., Han J., Burkhart K.M., Vaughn E.M., Roof M.B., RA Faaberg K.S.; RT "Attenuation of porcine reproductive and respiratory syndrome virus strain RT MN184 using chimeric construction with vaccine sequence."; RL Virology 371:418-429(2008). RN [34] {ECO:0000313|Proteomes:UP000149596, ECO:0000313|Proteomes:UP000150457} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PRRSV01 {ECO:0000313|EMBL:ACH87562.1}, PRRSV02 RC {ECO:0000313|EMBL:ACH87570.1}, and PRRSV03 RC {ECO:0000313|EMBL:ACH87578.1}; RA Chen H.T.; RT "Genomic sequence of Porcine Reproductive and Respiratory Syndrome Virus RT Isolate."; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. RN [35] {ECO:0000313|EMBL:ACJ71774.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CA {ECO:0000313|EMBL:ACJ71774.1}; RA Koo H.-N., Oh J.-M., Lee J.-K., Choi J.-Y., Lee K.-S., Roh J.-Y., Je Y.-H., RA Jin B.-R., Yoo S.-S., Kim J.-S., Kim Y.-I., Yoon I.-J., Woo S.-D.; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. RN [36] {ECO:0000313|EMBL:ACU01777.1, ECO:0000313|Proteomes:UP000144283} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VR-2332 {ECO:0000313|EMBL:ACU01777.1}; RX PubMed=19587037; DOI=10.1128/JVI.00834-09; RA Han J., Rutherford M.S., Faaberg K.S.; RT "The porcine reproductive and respiratory syndrome virus nsp2 cysteine RT protease domain possesses both trans- and cis-cleavage activities."; RL J. Virol. 83:9449-9463(2009). RN [37] {ECO:0000313|EMBL:ACO06937.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=GX0809 {ECO:0000313|EMBL:ACO06937.1}; RX PubMed=19559739; DOI=10.1016/j.virusres.2009.06.014; RA Zhou L., Chen S., Zhang J., Zeng J., Guo X., Ge X., Zhang D., Yang H.; RT "Molecular variation analysis of porcine reproductive and respiratory RT syndrome virus in China."; RL Virus Res. 145:97-105(2009). RN [38] {ECO:0000313|EMBL:ACP43269.1, ECO:0000313|Proteomes:UP000137421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Clone20 {ECO:0000313|EMBL:ACP43269.1}; RA Huang Q., Xiao S., Chen H.; RT "Genome sequencing of Porcine reproductive and respiratory syndrome virus RT strains Clone20."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [39] {ECO:0000313|EMBL:ACY29605.1, ECO:0000313|Proteomes:UP000124145} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SD1-100 {ECO:0000313|EMBL:ACY29605.1}; RA Zhang J., Wu J., Niu Z.; RT "Genome sequence analysis of two PRRSV isolates from pig herds in Shandong RT area, China."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [40] {ECO:0000313|EMBL:ACU01789.1, ECO:0000313|Proteomes:UP000126532} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VR-2332 {ECO:0000313|EMBL:ACU01789.1}; RX PubMed=20668084; DOI=10.1128/JVI.01208-10; RA Han J., Rutherford M.S., Faaberg K.S.; RT "Proteolytic products of the porcine reproductive and respiratory syndrome RT virus nsp2 replicase protein."; RL J. Virol. 84:10102-10112(2010). RN [41] {ECO:0000313|EMBL:ADM34154.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hun03 {ECO:0000313|EMBL:ADM34154.1}; RX PubMed=20713151; DOI=10.1016/j.mcp.2010.08.002; RA Balka G., Hornyak A., Dan A., Ladinig A., Biksi I., Rusvai M.; RT "PriProET based melting point analyses on PRRSV positive field samples."; RL Mol. Cell. Probes 24:411-414(2010). RN [42] {ECO:0000313|EMBL:AFN88231.1, ECO:0000313|Proteomes:UP000157935} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=VR2385 {ECO:0000313|EMBL:AFN88231.1}; RX PubMed=21763365; DOI=10.1016/j.virusres.2011.06.027; RA Ni Y.Y., Huang Y.W., Cao D., Opriessnig T., Meng X.J.; RT "Establishment of a DNA-launched infectious clone for a highly RT pneumovirulent strain of type 2 porcine reproductive and respiratory RT syndrome virus: identification and in vitro and in vivo characterization of RT a large spontaneous deletion in the nsp2 region."; RL Virus Res. 160:264-273(2011). RN [43] {ECO:0000313|EMBL:AFB17972.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CP07-401-9 {ECO:0000313|EMBL:AFB17972.1}; RX PubMed=22825696; DOI=10.1007/s00705-012-1408-6; RA Yoon S.H., Kim H., Park B., Kim H.; RT "Tracing the genetic history of porcine reproductive and respiratory RT syndrome viruses derived from the complete ORF 5-7 sequences: a Bayesian RT coalescent approach."; RL Arch. Virol. 157:2143-2151(2012). RN [44] {ECO:0000313|EMBL:AET99118.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Stendal_V1445/99 {ECO:0000313|EMBL:AET99118.1}; RX PubMed=22807507; RA Wernike K., Bonilauri P., Dauber M., Errington J., Revilla Fernandez S., RA Hjulsager C., Isaksson M., Stadejek T., Beer M., Hoffmann B.; RT "Porcine reproductive and respiratory syndrome virus: Interlaboratory ring RT trial to evaluate real-time reverse transcription polymerase chain reaction RT detection methods."; RL J. Vet. Diagn. Invest. 24:855-866(2012). RN [45] {ECO:0000313|EMBL:AFU75330.1, ECO:0000313|Proteomes:UP000136120} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SD23983 {ECO:0000313|EMBL:AFU75330.1}; RX PubMed=23043113; DOI=10.1073/pnas.1211145109; RA Fang Y., Treffers E.E., Li Y., Tas A., Sun Z., van der Meer Y., de Ru A.H., RA van Veelen P.A., Atkins J.F., Snijder E.J., Firth A.E.; RT "Efficient -2 frameshifting by mammalian ribosomes to synthesize an RT additional arterivirus protein."; RL Proc. Natl. Acad. Sci. U.S.A. 109:E2920-E2928(2012). RN [46] {ECO:0000313|EMBL:AFM73568.1, ECO:0000313|Proteomes:UP000114021} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A2MC2 {ECO:0000313|EMBL:AFM73568.1}; RX PubMed=22704065; DOI=10.1016/j.virol.2012.05.015; RA Nan Y., Wang R., Shen M., Faaberg K.S., Samal S.K., Zhang Y.J.; RT "Induction of type I interferons by a novel porcine reproductive and RT respiratory syndrome virus isolate."; RL Virology 432:261-270(2012). RN [47] {ECO:0000313|EMBL:AFN88231.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=VR2385 {ECO:0000313|EMBL:AFN88231.1}; RA Ni Y.Y.; RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases. RN [48] {ECO:0000313|EMBL:AFV25451.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=YN-2011 {ECO:0000313|EMBL:AFV25451.1}; RA Yan Y.-L., Gao H., Xin A.-G., Huang H., Shao Z.-Y., Zang Y.-T.; RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases. RN [49] {ECO:0000313|EMBL:AFV25451.1, ECO:0000313|Proteomes:UP000131113} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YN-2011 {ECO:0000313|EMBL:AFV25451.1}; RX PubMed=23405309; RA Yan Y., Xin A., Zhu G., Huang H., Liu Q., Shao Z., Zang Y., Chen L., RA Sun Y., Gao H.; RT "Complete genome sequence of a novel natural recombinant porcine RT reproductive and respiratory syndrome virus isolated from a pig farm in RT yunnan province, southwest china."; RL Genome Announc. 1:E00003-E00012(2013). RN [50] {ECO:0000313|Proteomes:UP000099314, ECO:0000313|Proteomes:UP000102546} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DK-1997-19407B {ECO:0000313|EMBL:AHA83156.1}, DK-2004-1-7-Pl RC {ECO:0000313|EMBL:AHA83174.1}, DK-2004-2-1 RC {ECO:0000313|EMBL:AHA83237.1}, DK-2010-10-2-1 RC {ECO:0000313|EMBL:AHA83201.1}, DK-2010-10-4-1 RC {ECO:0000313|EMBL:AHA83219.1}, DK-2010-10-7-1 RC {ECO:0000313|EMBL:AHA83192.1}, DK-2011-030311-1 RC {ECO:0000313|EMBL:AHA83165.1}, and DK-2012-01-11-3 RC {ECO:0000313|EMBL:AHA83147.1}; RX PubMed=24125764; DOI=10.1016/j.vetmic.2013.09.023; RA Kvisgaard L.K., Hjulsager C.K., Brar M.S., Leung F.C., Larsen L.E.; RT "Genetic dissection of complete genomes of Type 2 PRRS viruses isolated in RT Denmark over a period of 15 years."; RL Vet. Microbiol. 167:334-344(2013). RN [51] {ECO:0000313|EMBL:AHZ97947.1, ECO:0000313|Proteomes:UP000148226} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=GZ1101 {ECO:0000313|EMBL:AHZ97947.1}; RA Zhou L., Yang X.R., Tian Y., Yin S.Y., Geng G., Ge X.N., Guo X., Yang H.C.; RT "Genetic diversity of the porcine reproductive and respiratory syndrome RT virus in China during 2008-2012."; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [52] {ECO:0000313|EMBL:AHC53276.1, ECO:0000313|Proteomes:UP000165682} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=XW002 {ECO:0000313|EMBL:AHC53276.1}; RA Wang X., Murtaugh M.P., Stone S.; RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases. RN [53] {ECO:0000313|Proteomes:UP000132277, ECO:0000313|Proteomes:UP000148546} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DK-2010-10-13-1 {ECO:0000313|EMBL:AHF71371.1}, and RC DK-2011-88005-A8-Pl {ECO:0000313|EMBL:AHF71379.1}; RX PubMed=24371078; DOI=10.1128/JVI.02858-13; RA Martin-Valls G.E., Kvisgaard L.K., Tello M., Darwich L., Cortey M., RA Burgara-Estrella A.J., Hernandez J., Larsen L.E., Mateu E.; RT "Analysis of ORF5 and full-length genome sequences of porcine reproductive RT and respiratory syndrome virus isolates of genotypes 1 and 2 retrieved RT worldwide provides evidence that recombination is a common phenomenon and RT may produce mosaic isolates."; RL J. Virol. 88:3170-3181(2014). RN [54] {ECO:0000313|EMBL:AGW31706.1, ECO:0000313|Proteomes:UP000125927} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HK15 {ECO:0000313|EMBL:AGW31706.1}; RX PubMed=24698958; RA Brar M.S., Shi M., Hui R.K., Leung F.C.; RT "Genomic Evolution of Porcine Reproductive and Respiratory Syndrome Virus RT (PRRSV) Isolates Revealed by Deep Sequencing."; RL PLoS ONE 9:E88807-E88807(2014). RN [55] {ECO:0000313|EMBL:AIU44073.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C1 {ECO:0000313|EMBL:AIU44073.1}; RA Zhang J.E., Yang H., Guo J., Deng Z., Luo H., Luo M., Zhao B.; RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases. RN [56] {ECO:0000313|Proteomes:UP000115143, ECO:0000313|Proteomes:UP000116194} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Cw46 {ECO:0000313|EMBL:AKS03719.1}, TY RC {ECO:0000313|EMBL:AKS03926.1}, TY1 {ECO:0000313|EMBL:AKS03890.1}, and RC WSV {ECO:0000313|EMBL:AKS03935.1}; RA Huang Y.-L., Deng M.-C., Chang C.-Y., Huang T.-S., Tsai H.-J., Chang C., RA Wang F.-I.; RT "Molecular epidemiology of porcine reproductive and respiratory syndrome RT viruses isolated from 1991 to 2013 in Taiwan."; RL Arch. Virol. 0:0-0(2015). RN [57] {ECO:0000313|EMBL:AIU44073.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C1 {ECO:0000313|EMBL:AIU44073.1}; RX PubMed=25958135; DOI=10.1016/j.meegid.2015.05.006; RA Wang F.X., Qin L.T., Liu Y., Liu X., Sun N., Yang Y., Chen T., Zhu H.W., RA Ren J.Q., Sun Y.J., Cheng S.P., Wen Y.J.; RT "Novel Nsp2 deletion based on molecular epidemiology and evolution of RT porcine reproductive and respiratory syndrome virus in Shandong Province RT from 2013 to 2014."; RL Infect. Genet. Evol. 33:219-226(2015). RN [58] {ECO:0000313|EMBL:AKZ21429.1, ECO:0000313|Proteomes:UP000107343} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FJSD {ECO:0000313|EMBL:AKZ21429.1}; RA Murphy D.; RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases. RN [59] {ECO:0000313|Proteomes:UP000119324, ECO:0000313|Proteomes:UP000120724} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=14-64 {ECO:0000313|EMBL:ANP23748.1}, 14-67 RC {ECO:0000313|EMBL:ANP23755.1}, and 14-68 RC {ECO:0000313|EMBL:ANP23762.1}; RA Schirtzinger E., Hause B.; RT "Genetic diversity of porcine reproductive and respiratory syndrome virus RT membrane and glycoprotein genes determined by metagenomic sequencing of RT clinical samples."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [60] {ECO:0000313|EMBL:AKJ32566.1, ECO:0000313|Proteomes:UP000160540} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RVRp22 {ECO:0000313|EMBL:AKJ32566.1}; RX PubMed=26889041; DOI=10.1128/JVI.02836-15; RA Khatun A., Shabir N., Seo B.J., Kim B.S., Yoon K.J., Kim W.I.; RT "The Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive RT and Respiratory Syndrome Virus Is Maintained during Sequential Passages in RT Pigs."; RL J. Virol. 90:4454-4468(2016). RN [61] {ECO:0000313|EMBL:AVL27351.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DMZC217/2015 {ECO:0000313|EMBL:AVL27351.1}; RA Kim H.J., Triplett B.A.; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [62] {ECO:0000313|EMBL:AYP65178.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KU-N1706 {ECO:0000313|EMBL:AYP65178.1}; RX PubMed=30317394; RA Kwon T., Yoo S.J., Sunwoo S.Y., Lee D.U., Je S.H., Park J.W., Park C.K., RA Lyoo Y.S.; RT "Independent evolution of porcine reproductive and respiratory syndrome RT virus 2 with genetic heterogeneity in antigenic regions of structural RT proteins in Korea."; RL Arch. Virol. 0:0-0(2018). RN [63] {ECO:0000313|EMBL:AVL27351.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DMZC217/2015 {ECO:0000313|EMBL:AVL27351.1}; RX PubMed=29504285; RA Martinez-Bautista N.R., Sciutto-Conde E., Cervantes-Torres J., RA Segura-Velazquez R., Mercado Garcia M.C., Ramirez-Mendoza H., RA Trujillo Ortega M.E., Delgadillo Alvarez J., Castillo-Juarez H., RA Sanchez-Betancourt J.I.; RT "Phylogenetic analysis of ORF5 and ORF7 of porcine reproductive and RT respiratory syndrome (PRRS) virus and the frequency of wild-type PRRS virus RT in Mexico."; RL Transbound. Emerg. Dis. 0:0-0(2018). RN [64] {ECO:0000313|EMBL:QCO69288.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=14D279 {ECO:0000313|EMBL:QCO69288.1}; RA Kim S.-H., Park J.-Y., Lee K.-K., Park C.-K.; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. RN [65] {ECO:0000313|EMBL:QCO69288.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=14D279 {ECO:0000313|EMBL:QCO69288.1}; RX PubMed=30817949; DOI=.1016/j.jviromet.2019.02.008; RA Park J.Y., Kim S.H., Lee K.K., Kim Y.H., Moon B.Y., So B., Park C.K.; RT "Differential detection of porcine reproductive and respiratory syndrome RT virus genotypes by a fluorescence melting curve analysis using peptide RT nucleic acid probe-mediated one-step real-time RT-PCR."; RL J. Virol. Methods 267:29-34(2019). RN [66] {ECO:0000313|EMBL:QNL09737.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1951167 {ECO:0000313|EMBL:QNL09737.1}; RX PubMed=32817228; DOI=10.1007/s00705-019-04373-z; RA Lalonde C., Provost C., Gagnon C.A.; RT "Whole genome sequencing of porcine reproductive and respiratory syndrome RT virus (PRRSV) from field clinical samples improves the genomic surveillance RT of the virus."; RL J. Clin. Microbiol. 58:0-0(2020). RN [67] {ECO:0000313|EMBL:QGY98616.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=4115R-S1 {ECO:0000313|EMBL:QGY98616.1}; RA Yu F., Yan Y., Shi M., Liu H.-Z., Zhang H.-L., Yang Y.-B., Huang X.-Y., RA Gauger P.C., Zhang J., Zhang Y.-H., Tong G.-Z., Tian Z.-J., Chen J.-J., RA Cai X.-H., Liu D., Li G., An T.-Q.; RT "Phylogenetics, genomic recombination, and NSP2 polymorphic patterns of RT porcine reproductive and respiratory syndrome virus in China and the United RT States in 2014-2018."; RL J. Virol. 0:0-0(2020). CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}. CC -!- SIMILARITY: Belongs to the arteriviridae nucleocapsid family. CC {ECO:0000256|ARBA:ARBA00008461}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U18748; AAA85827.1; -; Genomic_RNA. DR EMBL; AF054970; AAC36680.1; -; Genomic_RNA. DR EMBL; AF090173; AAC64115.1; -; Genomic_RNA. DR EMBL; AF066183; AAD27658.1; -; Genomic_RNA. DR EMBL; AF095478; AAD37049.1; -; Genomic_RNA. DR EMBL; AF159149; AAG02140.1; -; Genomic_RNA. DR EMBL; AF176348; AAG13733.1; -; Genomic_RNA. DR EMBL; AF331831; AAG49626.1; -; Genomic_RNA. DR EMBL; AF299404; AAK20467.1; -; Genomic_RNA. DR EMBL; AY150564; AAO13198.1; -; Genomic_RNA. DR EMBL; AY256686; AAP81809.1; -; mRNA. DR EMBL; AY569972; AAS78207.1; -; Genomic_RNA. DR EMBL; AY585241; AAT00230.1; -; Genomic_RNA. DR EMBL; AY612613; AAU20782.1; -; Genomic_RNA. DR EMBL; DQ056373; AAY53878.1; -; Genomic_RNA. DR EMBL; DQ176021; ABB18280.1; -; Genomic_RNA. DR EMBL; DQ217415; ABB29771.1; -; Genomic_RNA. DR EMBL; DQ459471; ABE73144.1; -; Genomic_RNA. DR EMBL; EF442771; ABO40170.1; -; Genomic_RNA. DR EMBL; EF484033; ABO87448.1; -; Genomic_RNA. DR EMBL; EF441767; ABR23539.1; -; Genomic_RNA. DR EMBL; EF536001; ABU87648.1; -; Genomic_RNA. DR EMBL; EU360128; ABY66098.1; -; Genomic_RNA. DR EMBL; EU360129; ABY66107.1; -; Genomic_RNA. DR EMBL; FJ175687; ACH87562.1; -; Genomic_RNA. DR EMBL; FJ175688; ACH87570.1; -; Genomic_RNA. DR EMBL; FJ175689; ACH87578.1; -; Genomic_RNA. DR EMBL; FJ194950; ACJ71774.1; -; Genomic_RNA. DR EMBL; FJ800721; ACO06937.1; -; Genomic_RNA. DR EMBL; FJ899592; ACP43269.1; -; Genomic_RNA. DR EMBL; FJ524377; ACU01777.1; -; Genomic_RNA. DR EMBL; FJ524376; ACU01789.1; -; Genomic_RNA. DR EMBL; GQ914997; ACY29605.1; -; Genomic_RNA. DR EMBL; GU930363; ADM34154.1; -; Genomic_RNA. DR EMBL; JN651704; AET99118.1; -; Genomic_RNA. DR EMBL; JN809806; AFB17972.1; -; Genomic_RNA. DR EMBL; JQ087873; AFM73568.1; -; Genomic_RNA. DR EMBL; JX044140; AFN88231.1; -; mRNA. DR EMBL; JX258843; AFU75330.1; -; Genomic_RNA. DR EMBL; JX857698; AFV25451.1; -; Genomic_RNA. DR EMBL; KF287142; AGW31706.1; -; Genomic_RNA. DR EMBL; KC862575; AHA83147.1; -; Genomic_RNA. DR EMBL; KC862576; AHA83156.1; -; Genomic_RNA. DR EMBL; KC862577; AHA83165.1; -; Genomic_RNA. DR EMBL; KC862578; AHA83174.1; -; Genomic_RNA. DR EMBL; KC862580; AHA83192.1; -; Genomic_RNA. DR EMBL; KC862581; AHA83201.1; -; Genomic_RNA. DR EMBL; KC862583; AHA83219.1; -; Genomic_RNA. DR EMBL; KC862585; AHA83237.1; -; Genomic_RNA. DR EMBL; KF724413; AHC53276.1; -; Genomic_RNA. DR EMBL; KF183946; AHF71371.1; -; Genomic_RNA. DR EMBL; KF183947; AHF71379.1; -; Genomic_RNA. DR EMBL; KF771273; AHZ97947.1; -; Genomic_RNA. DR EMBL; KM229515; AIU44073.1; -; Viral_cRNA. DR EMBL; KM386622; AKJ32566.1; -; Genomic_RNA. DR EMBL; KP998405; AKS03719.1; -; Genomic_RNA. DR EMBL; KP998424; AKS03890.1; -; Genomic_RNA. DR EMBL; KP998428; AKS03926.1; -; Genomic_RNA. DR EMBL; KP998429; AKS03935.1; -; Genomic_RNA. DR EMBL; KP998474; AKZ21429.1; -; Genomic_RNA. DR EMBL; KT257945; ANP23748.1; -; Genomic_RNA. DR EMBL; KT257946; ANP23755.1; -; Genomic_RNA. DR EMBL; KT257947; ANP23762.1; -; Genomic_RNA. DR EMBL; MF352174; AVL27351.1; -; Genomic_RNA. DR EMBL; MG999919; AYP65178.1; -; Genomic_RNA. DR EMBL; AJ223079; CAA11090.1; -; Genomic_RNA. DR EMBL; MH829977; QCO69288.1; -; Genomic_RNA. DR EMBL; MN073130; QGY98616.1; -; Genomic_RNA. DR EMBL; MN865488; QNL09737.1; -; Genomic_RNA. DR RefSeq; NP_047413.1; NC_001961.1. DR GeneID; 1494888; -. DR KEGG; vg:1494888; -. DR OrthoDB; 21697at10239; -. DR Proteomes; UP000099314; Genome. DR Proteomes; UP000102546; Genome. DR Proteomes; UP000104281; Genome. DR Proteomes; UP000105699; Genome. DR Proteomes; UP000107343; Genome. DR Proteomes; UP000114021; Genome. DR Proteomes; UP000114928; Genome. DR Proteomes; UP000115075; Genome. DR Proteomes; UP000115143; Genome. DR Proteomes; UP000115425; Genome. DR Proteomes; UP000116194; Genome. DR Proteomes; UP000119097; Genome. DR Proteomes; UP000119324; Genome. DR Proteomes; UP000120031; Genome. DR Proteomes; UP000120724; Genome. DR Proteomes; UP000123439; Genome. DR Proteomes; UP000123754; Genome. DR Proteomes; UP000124145; Genome. DR Proteomes; UP000125927; Genome. DR Proteomes; UP000126532; Genome. DR Proteomes; UP000126860; Genome. DR Proteomes; UP000128580; Genome. DR Proteomes; UP000128982; Genome. DR Proteomes; UP000131113; Genome. DR Proteomes; UP000132277; Genome. DR Proteomes; UP000132908; Genome. DR Proteomes; UP000136120; Genome. DR Proteomes; UP000137421; Genome. DR Proteomes; UP000140239; Genome. DR Proteomes; UP000144283; Genome. DR Proteomes; UP000147722; Genome. DR Proteomes; UP000148226; Genome. DR Proteomes; UP000148546; Genome. DR Proteomes; UP000148928; Genome. DR Proteomes; UP000149596; Genome. DR Proteomes; UP000149815; Genome. DR Proteomes; UP000150457; Genome. DR Proteomes; UP000157935; Genome. DR Proteomes; UP000159529; Genome. DR Proteomes; UP000159672; Genome. DR Proteomes; UP000160540; Genome. DR Proteomes; UP000161288; Genome. DR Proteomes; UP000162391; Genome. DR Proteomes; UP000163702; Genome. DR Proteomes; UP000164333; Genome. DR Proteomes; UP000165682; Genome. DR Proteomes; UP000173209; Genome. DR Proteomes; UP000173839; Genome. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW. DR Gene3D; 6.10.140.90; -; 1. DR InterPro; IPR002484; Arte_nucleocap. DR InterPro; IPR037179; Nucleocapsid_C. DR Pfam; PF01481; Arteri_nucleo; 1. DR SUPFAM; SSF103068; Nucleocapsid protein dimerization domain; 1. PE 2: Evidence at transcript level; KW Reference proteome {ECO:0000313|Proteomes:UP000163702}; KW Viral nucleoprotein {ECO:0000313|EMBL:AAO13198.1}; KW Virion {ECO:0000313|EMBL:AAO13198.1}. FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 123 AA; 13576 MW; EB976E593C4C8E53 CRC64; MPNNNGKQQK RKKGDGQPVN QLCQMLGKII AQQNQSRGKG PGKKNKKKNP EKPHFPLATE DDVRHHFTPS ERQLCLSSIQ TAFNQGAGTC TLSDSGRISY TVEFSLPTHH TVRLIRVTAS PSA //