ID Q76NL8_PLAF7 Unreviewed; 1193 AA. AC Q76NL8; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 05-OCT-2016, entry version 83. DE SubName: Full=Falcilysin {ECO:0000313|EMBL:CAD52728.1}; DE EC=3.4.24.- {ECO:0000313|EMBL:CAD52728.1}; GN ORFNames=PF3D7_1360800 {ECO:0000313|EMBL:CAD52728.1}; OS Plasmodium falciparum (isolate 3D7). OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD52728.1, ECO:0000313|Proteomes:UP000001450}; RN [1] {ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=12368864; DOI=10.1038/nature01097; RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K., RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., RA Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., RA Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., RA Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., RA McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., RA Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., RA Fraser C.M., Barrell B.; RT "Genome sequence of the human malaria parasite Plasmodium RT falciparum."; RL Nature 419:498-511(2002). RN [2] {ECO:0000313|Proteomes:UP000001450} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450}; RX PubMed=12368867; DOI=10.1038/nature01095; RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., RA Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C., RA Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., RA Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., RA Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., RA Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., RA Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., RA Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., RA Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., RA Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., RA Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., RA Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., RA Sulston J.E., Craig A., Newbold C., Barrell B.G.; RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."; RL Nature 419:527-531(2002). RN [3] {ECO:0000213|PDB:3S5H, ECO:0000213|PDB:3S5I, ECO:0000213|PDB:3S5K} RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH MAGNESIUM AND RP ZINC, X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS), X-RAY CRYSTALLOGRAPHY RP (1.74 ANGSTROMS), AND X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN RP COMPLEX WITH ZINC. RA Morgunova E., Ponpuak M., Istvan E., Popov A., Goldberg D., RA Eneqvist T.; RT "Crystal structures of falcilysin, a M16 metalloprotease from the RT malaria parasite Plasmodium falciparum."; RL Submitted (MAY-2011) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL844509; CAD52728.1; -; Genomic_DNA. DR RefSeq; XP_001350319.1; XM_001350283.1. DR PDB; 3S5H; X-ray; 1.60 A; A=1-1193. DR PDB; 3S5I; X-ray; 1.74 A; A=1-1193. DR PDB; 3S5K; X-ray; 3.20 A; A=1-1193. DR PDB; 3S5M; X-ray; 1.55 A; A=1-1193. DR PDBsum; 3S5H; -. DR PDBsum; 3S5I; -. DR PDBsum; 3S5K; -. DR PDBsum; 3S5M; -. DR ProteinModelPortal; Q76NL8; -. DR IntAct; Q76NL8; 4. DR MINT; MINT-1609030; -. DR MEROPS; M16.011; -. DR SwissPalm; Q76NL8; -. DR EnsemblProtists; PF13_0322:mRNA; PF13_0322:pep; PF13_0322. DR GeneDB; PF3D7_1360800.1:pep; -. DR GeneID; 814283; -. DR KEGG; pfa:PF13_0322; -. DR EuPathDB; PlasmoDB:PF3D7_1360800; -. DR HOGENOM; HOG000281714; -. DR InParanoid; Q76NL8; -. DR KO; K06972; -. DR OMA; PSEDITY; -. DR PhylomeDB; Q76NL8; -. DR Proteomes; UP000001450; Chromosome 13. DR GO; GO:0020011; C:apicoplast; IDA:GeneDB. DR GO; GO:0020020; C:food vacuole; IDA:GeneDB. DR GO; GO:0004222; F:metalloendopeptidase activity; TAS:GeneDB. DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central. DR GO; GO:0042540; P:hemoglobin catabolic process; IDA:GeneDB. DR GO; GO:0016485; P:protein processing; IBA:GO_Central. DR Gene3D; 3.30.830.10; -; 2. DR InterPro; IPR011249; Metalloenz_LuxS/M16. DR InterPro; IPR011237; Pept_M16_dom. DR InterPro; IPR011765; Pept_M16_N. DR InterPro; IPR007863; Peptidase_M16_C. DR InterPro; IPR013578; Peptidase_M16C_assoc. DR Pfam; PF08367; M16C_assoc; 2. DR Pfam; PF00675; Peptidase_M16; 1. DR Pfam; PF05193; Peptidase_M16_C; 1. DR SMART; SM01264; M16C_associated; 1. DR SUPFAM; SSF63411; SSF63411; 4. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:3S5H, ECO:0000213|PDB:3S5I, KW ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001450}; KW Hydrolase {ECO:0000313|EMBL:CAD52728.1}; KW Magnesium {ECO:0000213|PDB:3S5M}; KW Metal-binding {ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}; KW Reference proteome {ECO:0000313|Proteomes:UP000001450}; KW Zinc {ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}. FT DOMAIN 584 901 M16C_associated. {ECO:0000259|SMART: FT SM01264}. FT COILED 583 619 {ECO:0000256|SAM:Coils}. FT COILED 895 922 {ECO:0000256|SAM:Coils}. FT METAL 129 129 Zinc; via tele nitrogen. FT {ECO:0000213|PDB:3S5K, ECO:0000213|PDB: FT 3S5M}. FT METAL 133 133 Zinc; via tele nitrogen. FT {ECO:0000213|PDB:3S5K, ECO:0000213|PDB: FT 3S5M}. FT METAL 152 152 Magnesium. {ECO:0000213|PDB:3S5M}. FT METAL 157 157 Magnesium; via tele nitrogen. FT {ECO:0000213|PDB:3S5M}. FT METAL 243 243 Zinc. {ECO:0000213|PDB:3S5K, FT ECO:0000213|PDB:3S5M}. SQ SEQUENCE 1193 AA; 138863 MW; DBA1FC548ED5056A CRC64; MNLTKLMKVI GYINIITNCV QSFTNRADKK RYNVFAKSFI NTINTNLYTF KAVMSKTPEW IHEKSPKHNS YDIIEKRYNE EFKMTYTVYQ HKKAKTQVIS LGTNDPLDVE QAFAFYVKTL THSGKGIPHI LEHSVLSGSK NYNYKNSIGL LEKGTLHTHL NAYTFNDRTV YMAGSMNNKD FFNIMGVYMD SVFQPNVLEN KYIFETEGWT YEVEKLKEDE KGKAEIPQMK DYKVSFNGIV YNEMKGALSS PLEDLYHEEM KYMFPDNVHS NNSGGDPKEI TNLTYEEFKE FYYKNYNPKK VKVFFFSKNN PTELLNFVDQ YLGQLDYSKY RDDAVESVEY QTYKKGPFYI KKKYGDHSEE KENLVSVAWL LNPKVDKTNN HNNNHSNNQS SENNGYSNGS HSSDLSLENP TDYFVLLIIN NLLIHTPESV LYKALTDCGL GNNVIDRGLN DSLVQYIFSI GLKGIKRNNE KIKNFDKVHY EVEDVIMNAL KKVVKEGFNK SAVEASINNI EFILKEANLK TSKSIDFVFE MTSKLNYNRD PLLIFEFEKY LNIVKNKIKN EPMYLEKFVE KHFINNAHRS VILLEGDENY AQEQENLEKQ ELKKRIENFN EQEKEQVIKN FEELSKYKNA EESPEHLNKF PIISISDLNK KTLEVPVNVY FTNINENNNI METYNKLKTN EHMLKDNMDV FLKKYVLKND KHNTNNNNNN NNNMDYSFTE TKYEGNVPIL VYEMPTTGIV YLQFVFSLDH LTVDELAYLN LFKTLILENK TNKRSSEDFV ILREKNIGSM SANVALYSKD DHLNVTDKYN AQALFNLEMH VLSHKCNDAL NIALEAVKES DFSNKKKVID ILKRKINGMK TTFSEKGYAI LMKYVKAHLN SKHYAHNIIY GYENYLKLQE QLELAENDFK TLENILVRIR NKIFNKKNLM VSVTSDYGAL KHLFVNSNES LKNLVSYFEE NDKYINDMQN KVNDPTVMGW NEEIKSKKLF DEEKVKKEFF VLPTFVNSVS MSGILFKPGE YLDPSFTVIV AALKNSYLWD TVRGLNGAYG VFADIEYDGS VVFLSARDPN LEKTLATFRE SAKGLRKMAD TMTENDLLRY IINTIGTIDK PRRGIELSKL SFLRLISNES EQDRVEFRKR IMNTKKEDFY KFADLLESKV NEFEKNIVII TTKEKANEYI ANVDGEFKKV LIE //