ID Q76NL8_PLAF7 Unreviewed; 1193 AA. AC Q76NL8; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 20-JAN-2016, entry version 75. DE SubName: Full=Falcilysin {ECO:0000313|EMBL:CAD52728.1}; GN Name=flN {ECO:0000313|EMBL:CAD52728.1}; GN ORFNames=PF13_0322 {ECO:0000313|EMBL:CAD52728.1}; OS Plasmodium falciparum (isolate 3D7). OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Laverania). OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAD52728.1, ECO:0000313|Proteomes:UP000001450}; RN [1] {ECO:0000213|PDB:3S5I, ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M} RP X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH MAGNESIUM AND RP ZINC, X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS), X-RAY CRYSTALLOGRAPHY RP (1.74 ANGSTROMS), AND X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN RP COMPLEX WITH ZINC. RA Morgunova E., Ponpuak M., Istvan E., Popov A., Goldberg D., RA Eneqvist T.; RT "Crystal structures of falcilysin, a M16 metalloprotease from the RT malaria parasite Plasmodium falciparum."; RL Submitted (MAY-2011) to the PDB data bank. CC -!- SIMILARITY: Belongs to the peptidase M16 family. CC {ECO:0000256|RuleBase:RU004447}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL844509; CAD52728.1; -; Genomic_DNA. DR RefSeq; XP_001350319.1; XM_001350283.1. DR PDB; 3S5H; X-ray; 1.60 A; A=1-1193. DR PDB; 3S5I; X-ray; 1.74 A; A=1-1193. DR PDB; 3S5K; X-ray; 3.20 A; A=1-1193. DR PDB; 3S5M; X-ray; 1.55 A; A=1-1193. DR PDBsum; 3S5H; -. DR PDBsum; 3S5I; -. DR PDBsum; 3S5K; -. DR PDBsum; 3S5M; -. DR ProteinModelPortal; Q76NL8; -. DR SMR; Q76NL8; 71-659. DR IntAct; Q76NL8; 4. DR MINT; MINT-1609030; -. DR MEROPS; M16.011; -. DR EnsemblProtists; PF13_0322:mRNA; PF13_0322:pep; PF13_0322. DR GeneDB; PF3D7_1360800.1:pep; -. DR GeneID; 814283; -. DR KEGG; pfa:PF13_0322; -. DR EuPathDB; PlasmoDB:PF3D7_1360800; -. DR HOGENOM; HOG000281714; -. DR InParanoid; Q76NL8; -. DR KO; K06972; -. DR OMA; PSEDITY; -. DR PhylomeDB; Q76NL8; -. DR Proteomes; UP000001450; Chromosome 13. DR GO; GO:0020011; C:apicoplast; IDA:GeneDB. DR GO; GO:0020020; C:food vacuole; IDA:GeneDB. DR GO; GO:0004222; F:metalloendopeptidase activity; TAS:GeneDB. DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central. DR GO; GO:0042540; P:hemoglobin catabolic process; IDA:GeneDB. DR GO; GO:0016485; P:protein processing; IBA:GO_Central. DR Gene3D; 3.30.830.10; -; 2. DR InterPro; IPR011249; Metalloenz_LuxS/M16. DR InterPro; IPR011237; Pept_M16_dom. DR InterPro; IPR011765; Pept_M16_N. DR InterPro; IPR007863; Peptidase_M16_C. DR InterPro; IPR013578; Peptidase_M16C_assoc. DR Pfam; PF08367; M16C_assoc; 2. DR Pfam; PF00675; Peptidase_M16; 1. DR Pfam; PF05193; Peptidase_M16_C; 1. DR SUPFAM; SSF63411; SSF63411; 4. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:3S5H, ECO:0000213|PDB:3S5I, KW ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000001450}; KW Magnesium {ECO:0000213|PDB:3S5M}; KW Metal-binding {ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}; KW Reference proteome {ECO:0000313|Proteomes:UP000001450}; KW Zinc {ECO:0000213|PDB:3S5K, ECO:0000213|PDB:3S5M}. FT DOMAIN 125 218 Peptidase_M16. {ECO:0000259|Pfam: FT PF00675}. FT DOMAIN 282 509 Peptidase_M16_C. {ECO:0000259|Pfam: FT PF05193}. FT DOMAIN 584 680 M16C_assoc. {ECO:0000259|Pfam:PF08367}. FT DOMAIN 718 899 M16C_assoc. {ECO:0000259|Pfam:PF08367}. FT COILED 583 619 {ECO:0000256|SAM:Coils}. FT COILED 895 922 {ECO:0000256|SAM:Coils}. FT METAL 129 129 Zinc; via tele nitrogen. FT {ECO:0000213|PDB:3S5K, ECO:0000213|PDB: FT 3S5M}. FT METAL 133 133 Zinc; via tele nitrogen. FT {ECO:0000213|PDB:3S5K, ECO:0000213|PDB: FT 3S5M}. FT METAL 152 152 Magnesium. {ECO:0000213|PDB:3S5M}. FT METAL 157 157 Magnesium; via tele nitrogen. FT {ECO:0000213|PDB:3S5M}. FT METAL 243 243 Zinc. {ECO:0000213|PDB:3S5K, FT ECO:0000213|PDB:3S5M}. SQ SEQUENCE 1193 AA; 138863 MW; DBA1FC548ED5056A CRC64; MNLTKLMKVI GYINIITNCV QSFTNRADKK RYNVFAKSFI NTINTNLYTF KAVMSKTPEW IHEKSPKHNS YDIIEKRYNE EFKMTYTVYQ HKKAKTQVIS LGTNDPLDVE QAFAFYVKTL THSGKGIPHI LEHSVLSGSK NYNYKNSIGL LEKGTLHTHL NAYTFNDRTV YMAGSMNNKD FFNIMGVYMD SVFQPNVLEN KYIFETEGWT YEVEKLKEDE KGKAEIPQMK DYKVSFNGIV YNEMKGALSS PLEDLYHEEM KYMFPDNVHS NNSGGDPKEI TNLTYEEFKE FYYKNYNPKK VKVFFFSKNN PTELLNFVDQ YLGQLDYSKY RDDAVESVEY QTYKKGPFYI KKKYGDHSEE KENLVSVAWL LNPKVDKTNN HNNNHSNNQS SENNGYSNGS HSSDLSLENP TDYFVLLIIN NLLIHTPESV LYKALTDCGL GNNVIDRGLN DSLVQYIFSI GLKGIKRNNE KIKNFDKVHY EVEDVIMNAL KKVVKEGFNK SAVEASINNI EFILKEANLK TSKSIDFVFE MTSKLNYNRD PLLIFEFEKY LNIVKNKIKN EPMYLEKFVE KHFINNAHRS VILLEGDENY AQEQENLEKQ ELKKRIENFN EQEKEQVIKN FEELSKYKNA EESPEHLNKF PIISISDLNK KTLEVPVNVY FTNINENNNI METYNKLKTN EHMLKDNMDV FLKKYVLKND KHNTNNNNNN NNNMDYSFTE TKYEGNVPIL VYEMPTTGIV YLQFVFSLDH LTVDELAYLN LFKTLILENK TNKRSSEDFV ILREKNIGSM SANVALYSKD DHLNVTDKYN AQALFNLEMH VLSHKCNDAL NIALEAVKES DFSNKKKVID ILKRKINGMK TTFSEKGYAI LMKYVKAHLN SKHYAHNIIY GYENYLKLQE QLELAENDFK TLENILVRIR NKIFNKKNLM VSVTSDYGAL KHLFVNSNES LKNLVSYFEE NDKYINDMQN KVNDPTVMGW NEEIKSKKLF DEEKVKKEFF VLPTFVNSVS MSGILFKPGE YLDPSFTVIV AALKNSYLWD TVRGLNGAYG VFADIEYDGS VVFLSARDPN LEKTLATFRE SAKGLRKMAD TMTENDLLRY IINTIGTIDK PRRGIELSKL SFLRLISNES EQDRVEFRKR IMNTKKEDFY KFADLLESKV NEFEKNIVII TTKEKANEYI ANVDGEFKKV LIE //