ID Q76HH2_THUAA Unreviewed; 348 AA. AC Q76HH2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 11-JUN-2014, entry version 50. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2; DE EC=1.6.5.3; GN Name=ND2; OS Thunnus alalunga (Albacore) (Scomber alalunga). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Pelagimorpharia; Scombriformes; Scombridae; Thunnus. OX NCBI_TaxID=8235; RN [1] RP NUCLEOTIDE SEQUENCE. RA Manchado M., Catanese G., Infante C.; RT "Complete mitochondrial DNA sequence of albacore (Thunnus alalunga)."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Martinez Ibarra C., Ishizaki S., Nagashima Y.; RT "Development of a PCR-based method for differentiation of tuna and RT related species in canned products."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RA Martinez Ibarra C., Ishizaki S., Nagashima Y.; RT "Development of a PCR-based method for differentiation of tuna and RT related species in canned products."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU256526; ADA69862.1; -; Genomic_DNA. DR EMBL; JN086151; AEI53252.1; -; Genomic_DNA. DR EMBL; AB101291; BAD06493.1; -; Genomic_DNA. DR RefSeq; NP_955706.1; NC_005317.1. DR GeneID; 2702240; -. DR CTD; 4536; -. DR HOVERGEN; HBG016692; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR001750; NADH_UbQ/plastoQ_OxRdtase. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Oxidored_q1; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; KW Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; KW Transmembrane; Transmembrane helix; Transport; Ubiquinone. SQ SEQUENCE 348 AA; 37632 MW; F0C05ECF3CECBA9F CRC64; MNPYILATLL FGLGLGTTIT FASSHWLLAW MGLEMNTLAI IPLMAQNHHP RAVEATTKYF LTQATAAAML LFASTTNAWL TGQWNIEQMT HPIPTTMIML ALALKIGLAP VHAWLPEVLQ GLDLTTGLIL STWQKLAPFA LILQIHPTNP ALLIVLGVAS TLVGGWGGLN QTQLRKILAY SSIAHLGWMI LILQFSPSLT LLTLLTYFIM TFSAFLVFKL NKATNINTLA TSWAKAPALT SLTPLVLLSL GGLPPLTGFM PKWLILQELS KQDLAPVATL AALSALLSLY FYLRLSYAMT LTMSPNNLSG TASWRLPSLQ PTLPVATSLV ATLALLPLTP AITAILTL //