ID UTS2B_HUMAN STANDARD; PRT; 119 AA. AC Q765I0; DT 01-FEB-2005 (Rel. 46, Created) DT 01-FEB-2005 (Rel. 46, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Urotensin-2B precursor (Urotensin-IIB) (U-IIB) (UIIB) (Urotensin II- DE related peptide). GN Name=UTS2B; Synonyms=URP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain; RX MEDLINE=22898141; PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102; RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.; RT "Identification of urotensin II-related peptide as the urotensin II- RT immunoreactive molecule in the rat brain."; RL Biochem. Biophys. Res. Commun. 310:860-868(2003). RN [2] RP NUCLEOTIDE SEQUENCE. RA Nothacker H.-P., Civelli O.; RT "Characterization of a novel urotensin II precursor: urotensin II B RT (U2B)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Potent vasoconstrictor (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- SIMILARITY: Belongs to the urotensin 2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB116021; BAC98929.1; -. DR EMBL; AY321313; AAQ83883.1; -. DR InterPro; IPR001483; Urotensin_II. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. KW Cleavage on pair of basic residues; Hormone; Signal. FT SIGNAL 1 28 Potential. FT PROPEP 29 109 By similarity. FT PEPTIDE 112 119 Urotensin-2B. FT DISULFID 113 118 By similarity. SQ SEQUENCE 119 AA; 13775 MW; D94C335DB222EE62 CRC64; MNKILSSTVC FGLLTLLSVL IFLQSVHGRP YLTQGNEIFP DKKYTNREEL LLALLNKNFD FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV DGLFSSHPSK RACFWKYCV //