ID UTS2B_HUMAN Reviewed; 119 AA. AC Q765I0; DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 02-OCT-2007, entry version 25. DE Urotensin-2B precursor (Urotensin-IIB) (U-IIB) (UIIB) (Urotensin II- DE related peptide) (Urotensin 2 domain-containing protein). GN Name=UTS2D; Synonyms=URP, UTS2B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=22898141; PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102; RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.; RT "Identification of urotensin II-related peptide as the urotensin II- RT immunoreactive molecule in the rat brain."; RL Biochem. Biophys. Res. Commun. 310:860-868(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Nothacker H.-P., Civelli O.; RT "Characterization of a novel urotensin II precursor: urotensin II B RT (U2B)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Potent vasoconstrictor (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- SIMILARITY: Belongs to the urotensin-2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB116021; BAC98929.1; -; mRNA. DR EMBL; AY321313; AAQ83883.1; -; mRNA. DR RefSeq; NP_937795.1; -. DR UniGene; Hs.518492; -. DR Ensembl; ENSG00000188958; Homo sapiens. DR GeneID; 257313; -. DR KEGG; hsa:257313; -. DR HGNC; HGNC:30894; UTS2D. DR PharmGKB; PA142670632; -. DR InterPro; IPR001483; Urotensin_II. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues; Hormone; Secreted; Signal. FT SIGNAL 1 28 Potential. FT PROPEP 29 109 By similarity. FT /FTId=PRO_0000036357. FT PEPTIDE 112 119 Urotensin-2B. FT /FTId=PRO_0000036358. FT DISULFID 113 118 By similarity. SQ SEQUENCE 119 AA; 13775 MW; D94C335DB222EE62 CRC64; MNKILSSTVC FGLLTLLSVL IFLQSVHGRP YLTQGNEIFP DKKYTNREEL LLALLNKNFD FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV DGLFSSHPSK RACFWKYCV //