ID UTS2B_HUMAN Reviewed; 119 AA. AC Q765I0; B3KQY8; D3DNW1; Q2M1Z2; DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot. DT 22-JUL-2008, sequence version 2. DT 24-JUL-2024, entry version 129. DE RecName: Full=Urotensin-2B; DE AltName: Full=Urotensin II-related peptide; DE AltName: Full=Urotensin IIB; DE Short=U-IIB; DE Short=UIIB; DE AltName: Full=Urotensin-2 domain-containing protein; DE Flags: Precursor; GN Name=UTS2B; Synonyms=URP, UTS2D; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-21. RC TISSUE=Brain; RX PubMed=14550283; DOI=10.1016/j.bbrc.2003.09.102; RA Sugo T., Murakami Y., Shimomura Y., Harada M., Abe M., Ishibashi Y., RA Kitada C., Miyajima N., Suzuki N., Mori M., Fujino M.; RT "Identification of urotensin II-related peptide as the urotensin II- RT immunoreactive molecule in the rat brain."; RL Biochem. Biophys. Res. Commun. 310:860-868(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-21. RA Nothacker H.-P., Civelli O.; RT "Characterization of a novel urotensin II precursor: urotensin II B RT (U2B)."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-21. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Cerebellum; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Potent vasoconstrictor. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB116021; BAC98929.1; -; mRNA. DR EMBL; AY321313; AAQ83883.1; -; mRNA. DR EMBL; AK090630; BAG52200.1; -; mRNA. DR EMBL; CH471052; EAW78091.1; -; Genomic_DNA. DR EMBL; CH471052; EAW78092.1; -; Genomic_DNA. DR EMBL; CH471052; EAW78093.1; -; Genomic_DNA. DR EMBL; CH471052; EAW78094.1; -; Genomic_DNA. DR EMBL; BC112166; AAI12167.1; -; mRNA. DR CCDS; CCDS3300.1; -. DR RefSeq; NP_937795.2; NM_198152.3. DR RefSeq; XP_011510933.1; XM_011512631.1. DR AlphaFoldDB; Q765I0; -. DR BioGRID; 129211; 2. DR IntAct; Q765I0; 1. DR STRING; 9606.ENSP00000340526; -. DR PhosphoSitePlus; Q765I0; -. DR BioMuta; UTS2B; -. DR DMDM; 212287929; -. DR jPOST; Q765I0; -. DR MassIVE; Q765I0; -. DR PaxDb; 9606-ENSP00000340526; -. DR Antibodypedia; 19374; 135 antibodies from 18 providers. DR DNASU; 257313; -. DR Ensembl; ENST00000340524.10; ENSP00000340526.5; ENSG00000188958.10. DR Ensembl; ENST00000427544.6; ENSP00000398761.2; ENSG00000188958.10. DR GeneID; 257313; -. DR KEGG; hsa:257313; -. DR MANE-Select; ENST00000340524.10; ENSP00000340526.5; NM_198152.5; NP_937795.2. DR UCSC; uc003fsu.4; human. DR AGR; HGNC:30894; -. DR CTD; 257313; -. DR DisGeNET; 257313; -. DR GeneCards; UTS2B; -. DR HGNC; HGNC:30894; UTS2B. DR HPA; ENSG00000188958; Tissue enhanced (intestine, retina). DR MIM; 618134; gene. DR neXtProt; NX_Q765I0; -. DR OpenTargets; ENSG00000188958; -. DR PharmGKB; PA142670632; -. DR VEuPathDB; HostDB:ENSG00000188958; -. DR eggNOG; ENOG502S3JR; Eukaryota. DR GeneTree; ENSGT00390000003511; -. DR HOGENOM; CLU_2060777_0_0_1; -. DR InParanoid; Q765I0; -. DR OMA; TMALCVP; -. DR OrthoDB; 5318638at2759; -. DR PhylomeDB; Q765I0; -. DR TreeFam; TF338338; -. DR PathwayCommons; Q765I0; -. DR Reactome; R-HSA-375276; Peptide ligand-binding receptors. DR Reactome; R-HSA-416476; G alpha (q) signalling events. DR SignaLink; Q765I0; -. DR BioGRID-ORCS; 257313; 10 hits in 1105 CRISPR screens. DR ChiTaRS; UTS2B; human. DR GenomeRNAi; 257313; -. DR Pharos; Q765I0; Tbio. DR PRO; PR:Q765I0; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; Q765I0; Protein. DR Bgee; ENSG00000188958; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 94 other cell types or tissues. DR ExpressionAtlas; Q765I0; baseline and differential. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro. DR GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central. DR InterPro; IPR043255; U-IIB. DR InterPro; IPR001483; Urotensin_II. DR PANTHER; PTHR36876; UROTENSIN-2B; 1. DR PANTHER; PTHR36876:SF1; UROTENSIN-2B; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. PE 3: Inferred from homology; KW Cleavage on pair of basic residues; Disulfide bond; Hormone; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..28 FT /evidence="ECO:0000255" FT PROPEP 29..109 FT /evidence="ECO:0000250" FT /id="PRO_0000036357" FT PEPTIDE 112..119 FT /note="Urotensin-2B" FT /id="PRO_0000036358" FT DISULFID 113..118 FT /evidence="ECO:0000250" FT VARIANT 21 FT /note="S -> I (in dbSNP:rs6788319)" FT /evidence="ECO:0000269|PubMed:14550283, FT ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2" FT /id="VAR_044517" SQ SEQUENCE 119 AA; 13749 MW; 389E27F6469DA596 CRC64; MNKILSSTVC FGLLTLLSVL SFLQSVHGRP YLTQGNEIFP DKKYTNREEL LLALLNKNFD FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV DGLFSSHPSK RACFWKYCV //