ID   INT8_HUMAN              Reviewed;         995 AA.
AC   Q75QN2; B2RN92; Q5RKZ3; Q6P1R5; Q7Z314; Q9NVS6; Q9NWY7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   19-JAN-2010, entry version 49.
DE   RecName: Full=Integrator complex subunit 8;
DE            Short=Int8;
DE   AltName: Full=Kaonashi protein 1;
DE            Short=Kaonashi-1;
GN   Name=INTS8; Synonyms=C8orf52;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Atsushi S., Asakawa S., Shimizu N.;
RT   "Novel gene with no significant domain.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain, Testis, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-995 (ISOFORM 2).
RC   TISSUE=Rectum tumor;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 307-995 (ISOFORM 1).
RC   TISSUE=Carcinoma, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
RP   INTEGRATOR COMPLEX.
RX   PubMed=16239144; DOI=10.1016/j.cell.2005.08.019;
RA   Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N.,
RA   Shiekhattar R.;
RT   "Integrator, a multiprotein mediator of small nuclear RNA processing,
RT   associates with the C-terminal repeat of RNA polymerase II.";
RL   Cell 123:265-276(2005).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Epithelium;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in
CC       their 3'-box-dependent processing. The Integrator complex is
CC       associated with the C-terminal domain (CTD) of RNA polymerase II
CC       largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC       genes.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7,
CC       INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q75QN2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q75QN2-2; Sequence=VSP_021469;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 4 TPR repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH50536.1; Type=Frameshift; Positions=985;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB161944; BAD10863.1; -; mRNA.
DR   EMBL; CH471060; EAW91726.1; -; Genomic_DNA.
DR   EMBL; BC050536; AAH50536.1; ALT_FRAME; mRNA.
DR   EMBL; BC064915; AAH64915.1; -; mRNA.
DR   EMBL; BC136754; AAI36755.1; -; mRNA.
DR   EMBL; BX538203; CAD98067.1; -; mRNA.
DR   EMBL; AK000537; BAA91238.1; ALT_INIT; mRNA.
DR   EMBL; AK001403; BAA91671.1; ALT_INIT; mRNA.
DR   EMBL; BK005731; DAA05731.1; -; mRNA.
DR   IPI; IPI00375653; -.
DR   IPI; IPI00797345; -.
DR   RefSeq; NP_060334.2; -.
DR   UniGene; Hs.521693; -.
DR   IntAct; Q75QN2; 1.
DR   STRING; Q75QN2; -.
DR   PhosphoSite; Q75QN2; -.
DR   PRIDE; Q75QN2; -.
DR   Ensembl; ENST00000343161; ENSP00000343274; ENSG00000164941; Homo sapiens.
DR   GeneID; 55656; -.
DR   KEGG; hsa:55656; -.
DR   UCSC; uc003yhb.1; human.
DR   UCSC; uc010mba.1; human.
DR   CTD; 55656; -.
DR   GeneCards; GC08P095906; -.
DR   H-InvDB; HIX0007655; -.
DR   HGNC; HGNC:26048; INTS8.
DR   MIM; 611351; gene.
DR   eggNOG; prNOG15754; -.
DR   HOGENOM; HBG356940; -.
DR   HOVERGEN; Q75QN2; -.
DR   InParanoid; Q75QN2; -.
DR   OMA; FLEQASK; -.
DR   OrthoDB; EOG9FN739; -.
DR   NextBio; 60375; -.
DR   ArrayExpress; Q75QN2; -.
DR   Bgee; Q75QN2; -.
DR   CleanEx; HS_INTS8; -.
DR   Genevestigator; Q75QN2; -.
DR   GermOnline; ENSG00000164941; Homo sapiens.
DR   GO; GO:0032039; C:integrator complex; IDA:HGNC.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0016180; P:snRNA processing; IDA:HGNC.
DR   PROSITE; PS50005; TPR; FALSE_NEG.
DR   PROSITE; PS50293; TPR_REGION; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Nucleus; Phosphoprotein;
KW   Repeat; TPR repeat.
FT   CHAIN         1    995       Integrator complex subunit 8.
FT                                /FTId=PRO_0000259553.
FT   REPEAT      250    288       TPR 1.
FT   REPEAT      320    356       TPR 2.
FT   REPEAT      570    603       TPR 3.
FT   REPEAT      833    866       TPR 4.
FT   MOD_RES      18     18       Phosphothreonine.
FT   VAR_SEQ     879    895       Missing (in isoform 2).
FT                                /FTId=VSP_021469.
FT   CONFLICT    778    778       V -> A (in Ref. 5; BAA91238).
FT   CONFLICT    832    832       N -> S (in Ref. 4; CAD98067).
SQ   SEQUENCE   995 AA;  113088 MW;  24D06E11821BD4D5 CRC64;
     MSAEAADREA ATSSRPCTPP QTCWFEFLLE ESLLEKHLRK PCPDPAPVQL IVQFLEQASK
     PSVNEQNQVQ PPPDNKRNRI LKLLALKVAA HLKWDLDILE KSLSVPVLNM LLNELLCISK
     VPPGTKHVDM DLATLPPTTA MAVLLYNRWA IRTIVQSSFP VKQAKPGPPQ LSVMNQMQQE
     KELTENILKV LKEQAADSIL VLEAALKLNK DLYVHTMRTL DLLAMEPGMV NGETESSTAG
     LKVKTEEMQC QVCYDLGAAY FQQGSTNSAV YENAREKFFR TKELIAEIGS LSLHCTIDEK
     RLAGYCQACD VLVPSSDSTS QQLTPYSQVH ICLRSGNYQE VIQIFIEDNL TLSLPVQFRQ
     SVLRELFKKA QQGNEALDEI CFKVCACNTV RDILEGRTIS VQFNQLFLRP NKEKIDFLLE
     VCSRSVNLEK ASESLKGNMA AFLKNVCLGL EDLQYVFMIS SHELFITLLK DEERKLLVDQ
     MRKRSPRVNL CIKPVTSFYD IPASASVNIG QLEHQLILSV DPWRIRQILI ELHGMTSERQ
     FWTVSNKWEV PSVYSGVILG IKDNLTRDLV YILMAKGLHC STVKDFSHAK QLFAACLELV
     TEFSPKLRQV MLNEMLLLDI HTHEAGTGQA GERPPSDLIS RVRGYLEMRL PDIPLRQVIA
     EECVAFMLNW RENEYLTLQV PAFLLQSNPY VKLGQLLAAT CKELPGPKES RRTAKDLWEV
     VVQICSVSSQ HKRGNDGRVS LIKQRESTLG IMYRSELLSF IKKLREPLVL TIILSLFVKL
     HNVREDIVND ITAEHISIWP SSIPNLQSVD FEAVAITVKE LVRYTLSINP NNHSWLIIQA
     DIYFATNQYS AALHYYLQAG AVCSDFFNKA VPPDVYTDQV IKRMIKCCSL LNCHTQVAIL
     CQFLREIDYK TAFKSLQEQN SHDAMDSYYD YIWDVTILEY LTYLHHKRGE TDKRQIAIKA
     IGQTELNASN PEEVLQLAAQ RRKKKFLQAM AKLYF
//