ID DED1_ASHGO Reviewed; 623 AA. AC Q75B50; DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 12-JUN-2007, entry version 28. DE ATP-dependent RNA helicase DED1 (EC 3.6.1.-). GN Name=DED1; OrderedLocusNames=ADL273C; OS Ashbya gossypii (Yeast) (Eremothecium gossypii). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Eremothecium. OX NCBI_TaxID=33169; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51; RX PubMed=15001715; DOI=10.1126/science.1095781; RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., RA Gaffney T.D., Philippsen P.; RT "The Ashbya gossypii genome as a tool for mapping the ancient RT Saccharomyces cerevisiae genome."; RL Science 304:304-307(2004). CC -!- FUNCTION: ATP-binding RNA helicase involved in translation CC initiation. Remodels RNA in response to ADP and ATP concentrations CC by facilitating disruption, but also formation of RNA duplexes (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD CC box family of RNA helicases and controls ATP binding and CC hydrolysis. CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1 CC subfamily. CC -!- SIMILARITY: Contains 1 helicase ATP-binding domain. CC -!- SIMILARITY: Contains 1 helicase C-terminal domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016817; AAS51647.1; -; Genomic_DNA. DR AGD; ADL273C; -. DR InterPro; IPR014001; DEAD-like_N. DR InterPro; IPR011545; DEAD/DEAH_N. DR InterPro; IPR000629; DEAD_box. DR InterPro; IPR014014; DEAD_Q_motif. DR InterPro; IPR014021; Helic_SF1/SF2_ATP_bd. DR InterPro; IPR001650; Helicase_C. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1. DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1. DR PROSITE; PS51194; HELICASE_CTER; 1. DR PROSITE; PS51195; Q_MOTIF; 1. KW ATP-binding; Complete proteome; Helicase; Hydrolase; KW Initiation factor; Nucleotide-binding; Protein biosynthesis; KW RNA-binding. FT CHAIN 1 623 ATP-dependent RNA helicase DED1. FT /FTId=PRO_0000227953. FT DOMAIN 177 365 Helicase ATP-binding. FT DOMAIN 392 536 Helicase C-terminal. FT NP_BIND 190 197 ATP (By similarity). FT MOTIF 146 174 Q motif. FT MOTIF 309 312 DEAD box. SQ SEQUENCE 623 AA; 67595 MW; 067857C2AFA91CAB CRC64; MSELVNKMEN LSVGDSAQKK SAYVPPHVKR RMKEGGSEPS SRNTENFGNG GRFGGSEHNG FGGGRGSWFG GNARGGGPRS SDRGGSSRFG KWVDGKHVPM KRNEKLEVQL FGTPEDPNFQ SSGINFDNYD DIPVDASGED VPDPITEFTS PPLDELLLEN IKLARFTKPT PVQKYSVPIV AKGRDLMACA QTGSGKTGGF LFPVLSQSFS NGPASTPDES GYYMRKAYPT AVVLAPTREL ATQIFDEAKK FTYRSWVKPC VVYGGADIRQ QIRELERGCD LIVATPGRLN DLLERGKISL CSVKYLVLDE ADRMLDMGFE PQIRHIVEGC DMPTVENRQT LMFSATFPTD IQHLAADFLK DYIFLSVGRV GSTSENITQK VLHVEDIDKR SVLLDLLAAS DGGLTLVFVE TKRMADALTD FLIMQNLSAT AIHGDRTQAE RERALAFFRT GRANVLVATA VAARGLDIPN VTHVINYDLP SDIDDYVHRI GRTGRAGNTG LATAFFNRGN KNVVKELVDI LEEANQEVPS FLSQIAKEMS YGGGGGKSSR GGRGGYSRGN STRDFRRHGG GGGSEWSSAN RASSGWGNAT RTGSGWGDSS GFGGSTESWS NASKTVGSNN SWW //