ID Q75B50_ASHGO PRELIMINARY; PRT; 623 AA. AC Q75B50; DT 05-JUL-2004 (TrEMBLrel. 27, Created) DT 05-JUL-2004 (TrEMBLrel. 27, Last sequence update) DT 05-JUL-2004 (TrEMBLrel. 27, Last annotation update) DE ADL273Cp. GN OrderedLocusNames=ADL273C; OS Ashbya gossypii (Yeast) (Eremothecium gossypii). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Eremothecium. OX NCBI_TaxID=33169; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 10895; RX PubMed=15001715; DOI=10.1126/science.1095781; RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., RA Gaffney T.D., Philippsen P.; RT "The Ashbya gossypii genome as a tool for mapping the ancient RT Saccharomyces cerevisiae genome."; RL Science 304:304-307(2004). CC -!- FUNCTION: EIF4A is both a subunit of a high molecular weight CC protein complex involved in cap recognition and is required as a CC single polypeptide chain for mRNA binding to ribosome. It is an CC ATP-dependent single stranded DNA-binding protein with a sequence- CC independent unwinding activity (helicase) (By similarity). CC -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of CC which varies with external and internal environmental conditions. CC It is composed of at least EIF4A, EIF4E and EIF4G (By similarity). CC -!- SIMILARITY: Belongs to the DEAD box helicase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016817; AAS51647.1; -. DR AGD; ADL273C; -. DR GO; GO:0005524; F:ATP binding; IEA. DR GO; GO:0008026; F:ATP-dependent helicase activity; IEA. DR GO; GO:0003676; F:nucleic acid binding; IEA. DR InterPro; IPR001410; DEAD. DR InterPro; IPR011545; DEAD/DEAH_N. DR InterPro; IPR000629; DEAD_box. DR InterPro; IPR001650; Helicase_C. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR SMART; SM00487; DEXDc; 1. DR SMART; SM00490; HELICc; 1. DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1. KW ATP-binding; Complete proteome; Helicase; Hydrolase; KW Initiation factor; Protein biosynthesis. SQ SEQUENCE 623 AA; 67594 MW; 067857C2AFA91CAB CRC64; MSELVNKMEN LSVGDSAQKK SAYVPPHVKR RMKEGGSEPS SRNTENFGNG GRFGGSEHNG FGGGRGSWFG GNARGGGPRS SDRGGSSRFG KWVDGKHVPM KRNEKLEVQL FGTPEDPNFQ SSGINFDNYD DIPVDASGED VPDPITEFTS PPLDELLLEN IKLARFTKPT PVQKYSVPIV AKGRDLMACA QTGSGKTGGF LFPVLSQSFS NGPASTPDES GYYMRKAYPT AVVLAPTREL ATQIFDEAKK FTYRSWVKPC VVYGGADIRQ QIRELERGCD LIVATPGRLN DLLERGKISL CSVKYLVLDE ADRMLDMGFE PQIRHIVEGC DMPTVENRQT LMFSATFPTD IQHLAADFLK DYIFLSVGRV GSTSENITQK VLHVEDIDKR SVLLDLLAAS DGGLTLVFVE TKRMADALTD FLIMQNLSAT AIHGDRTQAE RERALAFFRT GRANVLVATA VAARGLDIPN VTHVINYDLP SDIDDYVHRI GRTGRAGNTG LATAFFNRGN KNVVKELVDI LEEANQEVPS FLSQIAKEMS YGGGGGKSSR GGRGGYSRGN STRDFRRHGG GGGSEWSSAN RASSGWGNAT RTGSGWGDSS GFGGSTESWS NASKTVGSNN SWW //