ID DPH1_ASHGO STANDARD; PRT; 426 AA. AC Q75AZ9; DT 24-JAN-2006 (Rel. 49, Created) DT 24-JAN-2006 (Rel. 49, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Diphthamide biosynthesis protein 1. GN Name=DPH1; OrderedLocusNames=ADL229W; OS Ashbya gossypii (Yeast) (Eremothecium gossypii). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Eremothecium. OX NCBI_TaxID=33169; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 10895; RX PubMed=15001715; DOI=10.1126/science.1095781; RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., RA Gaffney T.D., Philippsen P.; RT "The Ashbya gossypii genome as a tool for mapping the ancient RT Saccharomyces cerevisiae genome."; RL Science 304:304-307(2004). CC -!- FUNCTION: Required for the first step of diphtamide biosynthesis, CC the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L- CC methionine to a histidine residue. Diphthamide is a post- CC translational modification of histidine which occurs in elongation CC factor 2 (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the DPH1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016817; AAS51691.1; -; Genomic_DNA. DR AGD; ADL229W; -. DR InterPro; IPR002728; Diphthamide_syn. DR PANTHER; PTHR10762; Diphthamide_syn; 1. DR Pfam; PF01866; Diphthamide_syn; 1. DR ProDom; PD004399; Diphthamide_syn; 1. DR TIGRFAMs; TIGR00322; diphth2_R; 1. KW Complete proteome. SQ SEQUENCE 426 AA; 48184 MW; F080D8449B600DDD CRC64; MSTADEVTKK PRRRFVGVSR GENKVSTKQV SGDEAKELVR SAKSNTGARR AINQIPDEIL NDENLQEAIK LLPSNYNFEI HKTVWNIRKH NAKRVALQMP EGLLIYSLVI SDILEQFCNC ETVVMGDVSY GACCIDDFTA RALGCDFIVH YAHSCLVPVD VTSIKILYVF VTIGIDEDHL MKTLQKNFAK GTSLAVFGTI QFNPAIHSIR EKLLYSESHM LYITPPQIKP LSKGEVLGCT SQRLPKEQFA AMVYVGDGRF HLESAMIHNP DIPAFRYDPY SRKFTRETYD QHQLVEVRSS AIEKARNSQC FGLILGALGR QGNLATVANL EKKLRAAGKK VVRIILSEIF PQKLAMFDHI DAFVQVACPR LSIDWGYAFN KPLLTPYETN VMLGQDRMFN EKYYPMDYYE VNGYGRGKQP THDNVI //