ID MUTL_LACJO Reviewed; 630 AA. AC Q74KW0; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 26-FEB-2008, entry version 36. DE DNA mismatch repair protein mutL. GN Name=mutL; OrderedLocusNames=LJ_0466; OS Lactobacillus johnsonii. OC Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; OC Lactobacillus. OX NCBI_TaxID=33959; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCC 533; RX PubMed=14983040; DOI=10.1073/pnas.0307327101; RA Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., RA Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., RA Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.; RT "The genome sequence of the probiotic intestinal bacterium RT Lactobacillus johnsonii NCC 533."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004). CC -!- FUNCTION: This protein is involved in the repair of mismatches in CC DNA. It is required for dam-dependent methyl-directed DNA mismatch CC repair. May act as a "molecular matchmaker", a protein that CC promotes the formation of a stable complex between two or more CC DNA-binding proteins in an ATP-dependent manner without itself CC being part of a final effector complex (By similarity). CC -!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017198; AAS08458.1; -; Genomic_DNA. DR RefSeq; NP_964492.1; -. DR HSSP; P23367; 1B62. DR GeneID; 2742151; -. DR GenomeReviews; AE017198_GR; LJ_0466. DR KEGG; ljo:LJ0466; -. DR BioCyc; LJOH257314:LJ_0466-MON; -. DR GO; GO:0006298; P:mismatch repair; IEA:HAMAP. DR HAMAP; MF_00149; -; 1. DR InterPro; IPR003594; ATP_bd_ATPase. DR InterPro; IPR002099; DNA_mismatch_repair. DR InterPro; IPR013507; DNA_mismatch_repair_C. DR InterPro; IPR014762; DNA_mismatch_repair_CS. DR InterPro; IPR014763; DNA_mismatch_repair_N. DR InterPro; IPR014790; MutL_C. DR Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1. DR PANTHER; PTHR10073; DNA_mis_repair; 1. DR Pfam; PF01119; DNA_mis_repair; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF08676; MutL_C; 1. DR SMART; SM00387; HATPase_c; 1. DR TIGRFAMs; TIGR00585; mutl; 1. DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1. PE 3: Inferred from homology; KW Complete proteome; DNA damage; DNA repair. FT CHAIN 1 630 DNA mismatch repair protein mutL. FT /FTId=PRO_1000010033. SQ SEQUENCE 630 AA; 71188 MW; 4B456B442FACE2C5 CRC64; MSKIHELSPE LTNQIAAGEV IERPASVVKE LCENSLDAGS KRIRIDFIDA GLKQITVQDN GSGIAKDQID LAFTRHATSK IATERDLFNI STLGFRGEAL ASIAAVSHVE VTTSNDNLGG VRAIFSGSEK KLQEDAASPK GTKITVSDLF FNTPARLKYL RSERTEILKI VDIVNRLALG HPDVSFTLTN NGKVLLKTNG RDDLRQDIAN IYGRQLAEKM NILKGKSPDF EISGLISDPN TTRSNRNFIS LLLNGRYIKN YRLTQAIMAG YGNKLRPRRY PIAVVKIELD PLLVDVNVHP TKQEVRLSKE QELERLLTTS ISEALEQNNQ IDSGLNNLLA PKKSTNIDQL KFNLNKDVVN TARPVEFTPQ VEPDQNAEVH ETGANFVSLD QVRNDDKYVI TSTWNDNVNQ QVQLSPFDEE KDMQGKDDSI ISSGDEILAN NLPELTYMGQ TKSYLIAHHE EDLYLIDQVN AYRRLAYDQI LQDLNSENIS QQGLLSPLIL DFSNVDYLKL KENLENLQEF GLFLEDFGQN SLILRTYPMW LQPDAEKNVR MILDLYLNQT EHDISKLKAQ IAGEITMRQS ARRRMLNPVE AQELLKELRN SSDPYQDFEG KIIIIQLSEN DLNKMFKKDE //