ID MUTL_LACJO Reviewed; 630 AA. AC Q74KW0; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 03-MAY-2023, entry version 125. DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149}; GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=LJ_0466; OS Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533). OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae; OC Lactobacillus. OX NCBI_TaxID=257314; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CNCM I-1225 / La1 / NCC 533; RX PubMed=14983040; DOI=10.1073/pnas.0307327101; RA Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., RA Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., RA Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.; RT "The genome sequence of the probiotic intestinal bacterium Lactobacillus RT johnsonii NCC 533."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004). CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA. CC It is required for dam-dependent methyl-directed DNA mismatch repair. CC May act as a 'molecular matchmaker', a protein that promotes the CC formation of a stable complex between two or more DNA-binding proteins CC in an ATP-dependent manner without itself being part of a final CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}. CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family. CC {ECO:0000255|HAMAP-Rule:MF_00149}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017198; AAS08458.1; -; Genomic_DNA. DR RefSeq; WP_011161603.1; NC_005362.1. DR AlphaFoldDB; Q74KW0; -. DR SMR; Q74KW0; -. DR STRING; 257314.LJ_0466; -. DR EnsemblBacteria; AAS08458; AAS08458; LJ_0466. DR KEGG; ljo:LJ_0466; -. DR PATRIC; fig|257314.6.peg.493; -. DR eggNOG; COG0323; Bacteria. DR HOGENOM; CLU_004131_4_1_9; -. DR OMA; AHERIMY; -. DR Proteomes; UP000000581; Chromosome. DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro. DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule. DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1. DR CDD; cd00782; MutL_Trans; 1. DR Gene3D; 3.30.230.10; -; 1. DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1. DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1. DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1. DR HAMAP; MF_00149; DNA_mis_repair; 1. DR InterPro; IPR014762; DNA_mismatch_repair_CS. DR InterPro; IPR020667; DNA_mismatch_repair_MutL. DR InterPro; IPR002099; DNA_mismatch_repair_N. DR InterPro; IPR013507; DNA_mismatch_S5_2-like. DR InterPro; IPR036890; HATPase_C_sf. DR InterPro; IPR038973; MutL/Mlh/Pms. DR InterPro; IPR014790; MutL_C. DR InterPro; IPR042120; MutL_C_dimsub. DR InterPro; IPR042121; MutL_C_regsub. DR InterPro; IPR037198; MutL_C_sf. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1. DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1. DR Pfam; PF01119; DNA_mis_repair; 1. DR Pfam; PF13589; HATPase_c_3; 1. DR Pfam; PF08676; MutL_C; 1. DR SMART; SM01340; DNA_mis_repair; 1. DR SMART; SM00853; MutL_C; 1. DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1. DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1. DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1. DR TIGRFAMs; TIGR00585; mutl; 1. DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1. PE 3: Inferred from homology; KW DNA damage; DNA repair; Reference proteome. FT CHAIN 1..630 FT /note="DNA mismatch repair protein MutL" FT /id="PRO_1000010033" SQ SEQUENCE 630 AA; 71188 MW; 4B456B442FACE2C5 CRC64; MSKIHELSPE LTNQIAAGEV IERPASVVKE LCENSLDAGS KRIRIDFIDA GLKQITVQDN GSGIAKDQID LAFTRHATSK IATERDLFNI STLGFRGEAL ASIAAVSHVE VTTSNDNLGG VRAIFSGSEK KLQEDAASPK GTKITVSDLF FNTPARLKYL RSERTEILKI VDIVNRLALG HPDVSFTLTN NGKVLLKTNG RDDLRQDIAN IYGRQLAEKM NILKGKSPDF EISGLISDPN TTRSNRNFIS LLLNGRYIKN YRLTQAIMAG YGNKLRPRRY PIAVVKIELD PLLVDVNVHP TKQEVRLSKE QELERLLTTS ISEALEQNNQ IDSGLNNLLA PKKSTNIDQL KFNLNKDVVN TARPVEFTPQ VEPDQNAEVH ETGANFVSLD QVRNDDKYVI TSTWNDNVNQ QVQLSPFDEE KDMQGKDDSI ISSGDEILAN NLPELTYMGQ TKSYLIAHHE EDLYLIDQVN AYRRLAYDQI LQDLNSENIS QQGLLSPLIL DFSNVDYLKL KENLENLQEF GLFLEDFGQN SLILRTYPMW LQPDAEKNVR MILDLYLNQT EHDISKLKAQ IAGEITMRQS ARRRMLNPVE AQELLKELRN SSDPYQDFEG KIIIIQLSEN DLNKMFKKDE //