ID RL2_THET2 Reviewed; 276 AA. AC Q72I07; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 26-NOV-2014, entry version 76. DE RecName: Full=50S ribosomal protein L2 {ECO:0000255|HAMAP-Rule:MF_01320}; GN Name=rplB {ECO:0000255|HAMAP-Rule:MF_01320}; GN OrderedLocusNames=TT_C1325; OS Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039). OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; OC Thermus. OX NCBI_TaxID=262724; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HB27 / ATCC BAA-163 / DSM 7039; RX PubMed=15064768; DOI=10.1038/nbt956; RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., RA Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., RA Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., RA Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.; RT "The genome sequence of the extreme thermophile Thermus RT thermophilus."; RL Nat. Biotechnol. 22:547-553(2004). CC -!- FUNCTION: One of the primary rRNA binding proteins. Required for CC association of the 30S and 50S subunits to form the 70S ribosome, CC for tRNA binding and peptide bond formation. It has been suggested CC to have peptidyltransferase activity; this is somewhat CC controversial. Makes several contacts with the 16S rRNA in the 70S CC ribosome. {ECO:0000255|HAMAP-Rule:MF_01320}. CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms a bridge to the CC 30S subunit in the 70S ribosome. {ECO:0000255|HAMAP- CC Rule:MF_01320}. CC -!- SIMILARITY: Belongs to the ribosomal protein L2P family. CC {ECO:0000255|HAMAP-Rule:MF_01320}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE017221; AAS81667.1; -; Genomic_DNA. DR RefSeq; YP_005294.1; NC_005835.1. DR PDB; 1VSA; X-ray; 3.71 A; B=1-276. DR PDB; 1VSP; X-ray; 3.83 A; B=1-276. DR PDB; 3D5B; X-ray; 3.21 A; D=1-276. DR PDB; 3D5D; X-ray; 3.21 A; D=1-276. DR PDB; 3F1F; X-ray; 3.00 A; D=1-276. DR PDB; 3F1H; X-ray; 3.00 A; D=1-276. DR PDB; 3MRZ; X-ray; 3.62 A; C=2-276. DR PDB; 3MS1; X-ray; 3.62 A; C=2-276. DR PDB; 3PYO; X-ray; 3.50 A; C=2-272. DR PDB; 3PYR; X-ray; 3.50 A; C=2-272. DR PDB; 3PYT; X-ray; 3.40 A; C=2-272. DR PDB; 3PYV; X-ray; 3.40 A; C=2-272. DR PDB; 4KBU; X-ray; 3.86 A; D=2-276. DR PDB; 4KBW; X-ray; 3.86 A; D=2-276. DR PDB; 4KCZ; X-ray; 3.50 A; D=2-276. DR PDB; 4KD2; X-ray; 3.50 A; D=2-276. DR PDB; 4KD9; X-ray; 3.50 A; D=2-276. DR PDB; 4KDB; X-ray; 3.50 A; D=2-276. DR PDB; 4KDH; X-ray; 4.00 A; D=2-276. DR PDB; 4KDK; X-ray; 4.00 A; D=2-276. DR PDB; 4KFI; X-ray; 3.40 A; D=2-272. DR PDB; 4KFL; X-ray; 3.40 A; D=2-272. DR PDB; 4L6J; X-ray; 3.40 A; D=2-272. DR PDB; 4L6L; X-ray; 3.40 A; D=2-272. DR PDB; 4QS1; X-ray; 3.80 A; D=2-276. DR PDB; 4QS3; X-ray; 3.80 A; D=2-276. DR PDBsum; 1VSA; -. DR PDBsum; 1VSP; -. DR PDBsum; 3D5B; -. DR PDBsum; 3D5D; -. DR PDBsum; 3F1F; -. DR PDBsum; 3F1H; -. DR PDBsum; 3MRZ; -. DR PDBsum; 3MS1; -. DR PDBsum; 3PYO; -. DR PDBsum; 3PYR; -. DR PDBsum; 3PYT; -. DR PDBsum; 3PYV; -. DR PDBsum; 4KBU; -. DR PDBsum; 4KBW; -. DR PDBsum; 4KCZ; -. DR PDBsum; 4KD2; -. DR PDBsum; 4KD9; -. DR PDBsum; 4KDB; -. DR PDBsum; 4KDH; -. DR PDBsum; 4KDK; -. DR PDBsum; 4KFI; -. DR PDBsum; 4KFL; -. DR PDBsum; 4L6J; -. DR PDBsum; 4L6L; -. DR PDBsum; 4QS1; -. DR PDBsum; 4QS3; -. DR ProteinModelPortal; Q72I07; -. DR SMR; Q72I07; 2-273. DR STRING; 262724.TTC1325; -. DR EnsemblBacteria; AAS81667; AAS81667; TT_C1325. DR GeneID; 2775711; -. DR KEGG; tth:TTC1325; -. DR PATRIC; 23953057; VBITheThe54392_1317. DR eggNOG; COG0090; -. DR KO; K02886; -. DR OMA; VYIRINE; -. DR OrthoDB; EOG6TR0J1; -. DR BioCyc; TTHE262724:GCAT-1340-MONOMER; -. DR EvolutionaryTrace; Q72I07; -. DR GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-HAMAP. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0016740; F:transferase activity; IEA:InterPro. DR GO; GO:0006412; P:translation; IEA:UniProtKB-HAMAP. DR Gene3D; 2.30.30.30; -; 1. DR Gene3D; 2.40.50.140; -; 1. DR Gene3D; 4.10.950.10; -; 1. DR HAMAP; MF_01320_B; Ribosomal_L2_B; 1. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom. DR InterPro; IPR014722; Rib_L2_dom2. DR InterPro; IPR002171; Ribosomal_L2. DR InterPro; IPR005880; Ribosomal_L2_bac/org-type. DR InterPro; IPR022669; Ribosomal_L2_C. DR InterPro; IPR022671; Ribosomal_L2_CS. DR InterPro; IPR014726; Ribosomal_L2_dom3. DR InterPro; IPR008991; Translation_prot_SH3-like. DR PANTHER; PTHR13691; PTHR13691; 1. DR PANTHER; PTHR13691:SF5; PTHR13691:SF5; 1. DR Pfam; PF00181; Ribosomal_L2; 1. DR Pfam; PF03947; Ribosomal_L2_C; 1. DR PIRSF; PIRSF002158; Ribosomal_L2; 1. DR SUPFAM; SSF50104; SSF50104; 1. DR SUPFAM; SSF50249; SSF50249; 1. DR TIGRFAMs; TIGR01171; rplB_bact; 1. DR PROSITE; PS00467; RIBOSOMAL_L2; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Ribonucleoprotein; Ribosomal protein; KW RNA-binding; rRNA-binding. FT CHAIN 1 276 50S ribosomal protein L2. FT /FTId=PRO_0000237259. FT STRAND 3 5 {ECO:0000244|PDB:4L6J}. FT STRAND 9 15 {ECO:0000244|PDB:3F1F}. FT STRAND 17 19 {ECO:0000244|PDB:3F1F}. FT HELIX 21 23 {ECO:0000244|PDB:3D5B}. FT STRAND 33 38 {ECO:0000244|PDB:3D5B}. FT STRAND 45 47 {ECO:0000244|PDB:3F1F}. FT STRAND 50 54 {ECO:0000244|PDB:3F1F}. FT STRAND 61 63 {ECO:0000244|PDB:3D5B}. FT TURN 67 72 {ECO:0000244|PDB:3F1F}. FT STRAND 77 83 {ECO:0000244|PDB:3F1F}. FT STRAND 88 90 {ECO:0000244|PDB:3F1F}. FT STRAND 92 100 {ECO:0000244|PDB:3F1F}. FT STRAND 102 106 {ECO:0000244|PDB:3F1F}. FT STRAND 108 110 {ECO:0000244|PDB:4KFI}. FT STRAND 114 123 {ECO:0000244|PDB:3PYT}. FT STRAND 126 128 {ECO:0000244|PDB:4KCZ}. FT STRAND 130 132 {ECO:0000244|PDB:3D5B}. FT TURN 133 135 {ECO:0000244|PDB:3F1F}. FT STRAND 141 148 {ECO:0000244|PDB:3D5B}. FT TURN 149 151 {ECO:0000244|PDB:3D5B}. FT STRAND 153 155 {ECO:0000244|PDB:3D5B}. FT STRAND 158 160 {ECO:0000244|PDB:4KD2}. FT STRAND 163 169 {ECO:0000244|PDB:3F1F}. FT STRAND 172 176 {ECO:0000244|PDB:3F1F}. FT TURN 178 180 {ECO:0000244|PDB:4KD9}. FT STRAND 182 186 {ECO:0000244|PDB:3F1F}. FT STRAND 190 197 {ECO:0000244|PDB:3D5B}. FT HELIX 199 203 {ECO:0000244|PDB:3F1F}. FT HELIX 209 215 {ECO:0000244|PDB:3F1F}. FT HELIX 223 225 {ECO:0000244|PDB:3F1F}. FT TURN 228 230 {ECO:0000244|PDB:3F1F}. FT TURN 232 235 {ECO:0000244|PDB:4L6J}. FT STRAND 237 239 {ECO:0000244|PDB:3F1F}. FT STRAND 243 245 {ECO:0000244|PDB:3F1F}. FT HELIX 265 269 {ECO:0000244|PDB:3F1F}. FT STRAND 270 272 {ECO:0000244|PDB:4KD2}. SQ SEQUENCE 276 AA; 30468 MW; 7CF40C2BD586349B CRC64; MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW GWQTKGLKTR KRRKPSSRFI IARRKK //