ID AT5G3_RAT STANDARD; PRT; 142 AA. AC Q71S46; DT 25-OCT-2004 (Rel. 45, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE ATP synthase lipid-binding protein, mitochondrial precursor DE (EC 3.6.3.14) (ATP synthase proteolipid P3) (ATPase protein 9) (ATPase DE subunit C). GN Name=Atp5g3; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=21352956; PubMed=11459924; RA Li H.S., Zhang J.Y., Thompson B.S., Deng X.Y., Ford M.E., Wood P.G., RA Stolz D.B., Eagon P.K., Whitcomb D.C.; RT "Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in RT pancreas after chronic ethanol feeding."; RL Physiol. Genomics 6:91-98(2001). CC -!- FUNCTION: This protein is one of the chains of the nonenzymatic CC membrane component (F0) of mitochondrial ATPase. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + CC H(+)(Out). CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic CC core - and CF(0) - the membrane proton channel. CF(1) has five CC subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) CC has three main subunits: a, b and c. CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial membrane; CC multi-pass membrane protein (By similarity). CC -!- DISEASE: This protein is the major protein stored in the storage CC bodies of animals or humans affected with ceroid lipofuscinosis CC (Batten disease). CC -!- MISCELLANEOUS: There are three genes which encode the CC mitochondrial ATP synthase proteolipid and they specify precursors CC with different import sequences but identical mature proteins CC (Potential). CC -!- SIMILARITY: Belongs to the ATPase C chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF315374; AAG60677.1; -; mRNA. DR Ensembl; ENSRNOG00000001596; Rattus norvegicus. DR RGD; 620052; Atp5g3. DR InterPro; IPR002379; ATPase_Csub. DR InterPro; IPR000454; Eub_ATPase_Csub. DR Pfam; PF00137; ATP-synt_C; 1. DR PRINTS; PR00124; ATPASEC. DR PROSITE; PS00605; ATPASE_C; 1. KW CF(0); Hydrogen ion transport; Ion transport; Lipid-binding; Membrane; KW Mitochondrion; Transit peptide; Transmembrane; Transport. FT TRANSIT 1 67 Mitochondrion (By similarity). FT CHAIN 68 142 ATP synthase lipid-binding protein. FT /FTId=PRO_0000002570. FT TRANSMEM 83 103 Potential. FT TRANSMEM 118 138 Potential. FT SITE 125 125 Reversibly protonated during proton FT transport (By similarity). SQ SEQUENCE 142 AA; 14693 MW; 19EC0D1710A0AA3F CRC64; MFACAKLACT PSLIRAGSRV AYRPISASVL SRPEASRTGE GSTVFNGAQN GVSQLIQREF QTSAISRDID TAAKFIGAGA ATVGVAGSGA GIGTVFGSLI IGYARNPSLK QQLFSYAILG FALSEAMGLF CLMVAFLILF AM //