ID CNTFR_CANLF Reviewed; 372 AA. AC Q71DR4; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 05-OCT-2016, entry version 91. DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha; DE Short=CNTF receptor subunit alpha; DE Short=CNTFR-alpha; DE Flags: Precursor; GN Name=CNTFR; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; OC Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12882818; DOI=10.1167/iovs.02-0763; RA Beltran W.A., Zhang Q., Kijas J.W., Gu D., Rohrer H., Jordan J.A., RA Aguirre G.D.; RT "Cloning, mapping, and retinal expression of the canine ciliary RT neurotrophic factor receptor alpha (CNTFRalpha)."; RL Invest. Ophthalmol. Vis. Sci. 44:3642-3649(2003). CC -!- FUNCTION: Binds to CNTF. The alpha subunit provides the receptor CC specificity (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Heterotrimer of the alpha subunit, LIFR and IL6ST. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, CC GPI-anchor {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in retina, brain, spleen, lung, CC liver and kidney. In the retina it is highly expressed by CC photoreceptors, but also found in the RPE, inner nuclear layer and CC ganglion cells. {ECO:0000269|PubMed:12882818}. CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein CC folding and thereby efficient intracellular transport and cell- CC surface receptor binding. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 CC subfamily. {ECO:0000305}. CC -!- SIMILARITY: Contains 2 fibronectin type-III domains. CC {ECO:0000255|PROSITE-ProRule:PRU00316}. CC -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) CC domain. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF529215; AAQ09101.1; -; mRNA. DR RefSeq; NP_001003353.1; NM_001003353.1. DR RefSeq; XP_005626431.1; XM_005626374.2. DR RefSeq; XP_005626433.1; XM_005626376.2. DR RefSeq; XP_005626434.1; XM_005626377.2. DR RefSeq; XP_013973126.1; XM_014117651.1. DR UniGene; Cfa.3908; -. DR ProteinModelPortal; Q71DR4; -. DR STRING; 9615.ENSCAFP00000002838; -. DR PaxDb; Q71DR4; -. DR Ensembl; ENSCAFT00000003056; ENSCAFP00000002838; ENSCAFG00000001932. DR GeneID; 442941; -. DR KEGG; cfa:442941; -. DR CTD; 1271; -. DR eggNOG; ENOG410IH2U; Eukaryota. DR eggNOG; ENOG4110HUW; LUCA. DR GeneTree; ENSGT00530000063103; -. DR HOGENOM; HOG000171060; -. DR HOVERGEN; HBG051048; -. DR InParanoid; Q71DR4; -. DR KO; K05059; -. DR OMA; QETPHVQ; -. DR OrthoDB; EOG091G0B8P; -. DR TreeFam; TF331210; -. DR Reactome; R-CFA-6788467; IL-6-type cytokine receptor ligand interactions. DR Proteomes; UP000002254; Chromosome 11. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl. DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IEA:Ensembl. DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IEA:Ensembl. DR GO; GO:0004897; F:ciliary neurotrophic factor receptor activity; IEA:Ensembl. DR GO; GO:0003360; P:brainstem development; IEA:Ensembl. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl. DR GO; GO:0007548; P:sex differentiation; IEA:Ensembl. DR GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl. DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR Pfam; PF00041; fn3; 1. DR SMART; SM00060; FN3; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR PROSITE; PS50853; FN3; 2. DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; KW GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Receptor; KW Reference proteome; Repeat; Signal. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 342 Ciliary neurotrophic factor receptor FT subunit alpha. FT /FTId=PRO_0000010989. FT PROPEP 343 372 Removed in mature form. {ECO:0000255}. FT /FTId=PRO_0000010990. FT DOMAIN 27 104 Ig-like C2-type. FT DOMAIN 108 205 Fibronectin type-III 1. FT {ECO:0000255|PROSITE-ProRule:PRU00316}. FT DOMAIN 206 306 Fibronectin type-III 2. FT {ECO:0000255|PROSITE-ProRule:PRU00316}. FT MOTIF 290 294 WSXWS motif. FT LIPID 342 342 GPI-anchor amidated serine. FT {ECO:0000255}. FT CARBOHYD 60 60 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 70 70 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 142 142 N-linked (GlcNAc...). {ECO:0000255}. FT CARBOHYD 190 190 N-linked (GlcNAc...). {ECO:0000255}. FT DISULFID 46 89 {ECO:0000255|PROSITE-ProRule:PRU00114}. SQ SEQUENCE 372 AA; 40831 MW; 529405A00807BC0A CRC64; MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LIHVPVTLAL AAAAATANSL LI //