ID CNTFR_CANLF Reviewed; 372 AA. AC Q71DR4; DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 03-AUG-2022, entry version 120. DE RecName: Full=Ciliary neurotrophic factor receptor subunit alpha; DE Short=CNTF receptor subunit alpha; DE Short=CNTFR-alpha; DE Flags: Precursor; GN Name=CNTFR; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=12882818; DOI=10.1167/iovs.02-0763; RA Beltran W.A., Zhang Q., Kijas J.W., Gu D., Rohrer H., Jordan J.A., RA Aguirre G.D.; RT "Cloning, mapping, and retinal expression of the canine ciliary RT neurotrophic factor receptor alpha (CNTFRalpha)."; RL Invest. Ophthalmol. Vis. Sci. 44:3642-3649(2003). CC -!- FUNCTION: Binds to CNTF. The alpha subunit provides the receptor CC specificity (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Forms a heterotrimer with LIFR and IL6ST. Interacts with CC heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF- CC 1. Either alone or in complex with the heterodimer CLCF1-CRLF1 CC interacts with SORL1; this interaction may promote internalization and CC lysosomal degradation. {ECO:0000250|UniProtKB:P26992}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI- CC anchor {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Expressed in retina, brain, spleen, lung, liver and CC kidney. In the retina it is highly expressed by photoreceptors, but CC also found in the RPE, inner nuclear layer and ganglion cells. CC {ECO:0000269|PubMed:12882818}. CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein CC folding and thereby efficient intracellular transport and cell-surface CC receptor binding. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF529215; AAQ09101.1; -; mRNA. DR RefSeq; NP_001003353.1; NM_001003353.1. DR RefSeq; XP_005626431.1; XM_005626374.2. DR RefSeq; XP_005626433.1; XM_005626376.2. DR RefSeq; XP_005626434.1; XM_005626377.2. DR RefSeq; XP_013973126.1; XM_014117651.1. DR AlphaFoldDB; Q71DR4; -. DR BMRB; Q71DR4; -. DR SMR; Q71DR4; -. DR STRING; 9612.ENSCAFP00000002838; -. DR PaxDb; Q71DR4; -. DR Ensembl; ENSCAFT00040016416; ENSCAFP00040014222; ENSCAFG00040008832. DR Ensembl; ENSCAFT00845042894; ENSCAFP00845033622; ENSCAFG00845024273. DR GeneID; 442941; -. DR KEGG; cfa:442941; -. DR CTD; 1271; -. DR VEuPathDB; HostDB:ENSCAFG00845024273; -. DR eggNOG; ENOG502QUDK; Eukaryota. DR GeneTree; ENSGT00940000158864; -. DR HOGENOM; CLU_047259_0_0_1; -. DR InParanoid; Q71DR4; -. DR OMA; KICDTGE; -. DR OrthoDB; 741136at2759; -. DR TreeFam; TF331210; -. DR Reactome; R-CFA-6788467; IL-6-type cytokine receptor ligand interactions. DR Proteomes; UP000002254; Chromosome 11. DR Bgee; ENSCAFG00000001932; Expressed in thymus and 45 other tissues. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; IBA:GO_Central. DR GO; GO:0097059; C:CNTFR-CLCF1 complex; IBA:GO_Central. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0043235; C:receptor complex; IBA:GO_Central. DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central. DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central. DR GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; -; 3. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR Pfam; PF00041; fn3; 1. DR SMART; SM00060; FN3; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR PROSITE; PS50853; FN3; 2. DR PROSITE; PS01354; HEMATOPO_REC_L_F3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; KW Immunoglobulin domain; Lipoprotein; Membrane; Receptor; Reference proteome; KW Repeat; Signal. FT SIGNAL 1..22 FT /evidence="ECO:0000255" FT CHAIN 23..342 FT /note="Ciliary neurotrophic factor receptor subunit alpha" FT /id="PRO_0000010989" FT PROPEP 343..372 FT /note="Removed in mature form" FT /evidence="ECO:0000255" FT /id="PRO_0000010990" FT DOMAIN 27..104 FT /note="Ig-like C2-type" FT DOMAIN 108..205 FT /note="Fibronectin type-III 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT DOMAIN 206..306 FT /note="Fibronectin type-III 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316" FT REGION 301..340 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 290..294 FT /note="WSXWS motif" FT COMPBIAS 312..330 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT LIPID 342 FT /note="GPI-anchor amidated serine" FT /evidence="ECO:0000255" FT CARBOHYD 60 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 70 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 142 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 190 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 46..89 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114" SQ SEQUENCE 372 AA; 40831 MW; 529405A00807BC0A CRC64; MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN GTDLALDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI LDQWQHVELS DGTTHTITDA YAGKEYIIQV AAKDYEIGTW SDWSVAAHAT PWTEEPRHLT TEAQAPETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LIHVPVTLAL AAAAATANSL LI //