ID NU4LM_RHYRA Reviewed; 98 AA. AC Q70XJ0; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 14-DEC-2022, entry version 60. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L; OS Rhyncholestes raphanurus (Chilean shrew opossum). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Paucituberculata; Caenolestidae; Rhyncholestes. OX NCBI_TaxID=33559; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=15475160; DOI=10.1016/j.gene.2004.07.040; RA Nilsson M.A., Arnason U., Spencer P.B.S., Janke A.; RT "Marsupial relationships and a timeline for marsupial radiation in South RT Gondwana."; RL Gene 340:189-196(2004). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. {ECO:0000250|UniProtKB:P03902}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000250|UniProtKB:P03902}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ508399; CAD48221.1; -; Genomic_DNA. DR RefSeq; YP_003721.1; NC_005829.1. DR AlphaFoldDB; Q70XJ0; -. DR SMR; Q70XJ0; -. DR GeneID; 2769054; -. DR CTD; 4539; -. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix; KW Transport; Ubiquinone. FT CHAIN 1..98 FT /note="NADH-ubiquinone oxidoreductase chain 4L" FT /id="PRO_0000275119" FT TRANSMEM 1..21 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 26..46 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 59..79 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 98 AA; 10665 MW; 55E154BC128450C9 CRC64; MTTIYLNLIL AFTLALSGVL IYRSHLLSTL LCLEGMMLSL FILMALTISH FHMFSLSMAP LILLVFSACE AGVGLALLVK TSNAHGNDHV QSLNLLQC //