ID NU4LM_RHYRA Reviewed; 98 AA. AC Q70XJ0; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 05-DEC-2018, entry version 53. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 4L; GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L; OS Rhyncholestes raphanurus (Chilean shrew opossum). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Paucituberculata; Caenolestidae; Rhyncholestes. OX NCBI_TaxID=33559; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=15475160; DOI=10.1016/j.gene.2004.07.040; RA Nilsson M.A., Arnason U., Spencer P.B.S., Janke A.; RT "Marsupial relationships and a timeline for marsupial radiation in RT South Gondwana."; RL Gene 340:189-196(2004). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi- CC pass membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ508399; CAD48221.1; -; Genomic_DNA. DR RefSeq; YP_003721.1; NC_005829.1. DR SMR; Q70XJ0; -. DR GeneID; 2769054; -. DR CTD; 4539; -. DR HOVERGEN; HBG071122; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434; PTHR11434; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; KW Ubiquinone. FT CHAIN 1 98 NADH-ubiquinone oxidoreductase chain 4L. FT /FTId=PRO_0000275119. FT TRANSMEM 1 21 Helical. {ECO:0000255}. FT TRANSMEM 26 46 Helical. {ECO:0000255}. FT TRANSMEM 59 79 Helical. {ECO:0000255}. SQ SEQUENCE 98 AA; 10665 MW; 55E154BC128450C9 CRC64; MTTIYLNLIL AFTLALSGVL IYRSHLLSTL LCLEGMMLSL FILMALTISH FHMFSLSMAP LILLVFSACE AGVGLALLVK TSNAHGNDHV QSLNLLQC //