ID   Q70AG6_RAT              Unreviewed;       169 AA.
AC   Q70AG6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   22-FEB-2023, entry version 82.
DE   SubName: Full=Activation-induced cytidine deaminase {ECO:0000313|EMBL:CAE54297.2};
DE            EC=3.5.4.5 {ECO:0000313|EMBL:CAE54297.2};
DE   Flags: Fragment;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE54297.2};
RN   [1] {ECO:0000313|EMBL:CAE54297.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB-DR {ECO:0000313|EMBL:CAE54297.2};
RC   TISSUE=Peyer's Patches {ECO:0000313|EMBL:CAE54297.2};
RA   Hendicks J., Dammers P.M., Visser A., Kroese F.G.M.;
RT   "Cloning of rat activated induced deaminase from Peyer's Patches.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAE54297.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB-DR {ECO:0000313|EMBL:CAE54297.2};
RC   TISSUE=Peyer's Patches {ECO:0000313|EMBL:CAE54297.2};
RA   Hendricks J.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; AJ606071; CAE54297.2; -; mRNA.
DR   AlphaFoldDB; Q70AG6; -.
DR   BindingDB; Q70AG6; -.
DR   ChEMBL; CHEMBL3653; -.
DR   iPTMnet; Q70AG6; -.
DR   PhosphoSitePlus; Q70AG6; -.
DR   UCSC; RGD:1303222; rat.
DR   PhylomeDB; Q70AG6; -.
DR   GO; GO:0004126; F:cytidine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01283; cytidine_deaminase; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_dom.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   PANTHER; PTHR13857; MRNA EDITING ENZYME; 1.
DR   PANTHER; PTHR13857:SF10; SINGLE-STRANDED DNA CYTOSINE DEAMINASE; 1.
DR   Pfam; PF18772; APOBEC2; 1.
DR   SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1.
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000313|EMBL:CAE54297.2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          1..100
FT                   /note="CMP/dCMP-type deaminase"
FT                   /evidence="ECO:0000259|PROSITE:PS51747"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAE54297.2"
SQ   SEQUENCE   169 AA;  20352 MW;  FFA2AF6151489FCF CRC64;
     CYVVKRRDSA TSFSLDFGHL RNKSGCHVEL LFLRYISDWD LDPGRCYRVT WFTSWSPCYD
     CARHVAEFLR WNPNLSLRIF TARLYFCEDR KAEPEGLRRL HRAGVQIGIM TFKDYFYCWN
     TFVENHERTF KAWEGLHENS VRLTRQLRRI LLPLYEVDDL RDAFRILGL
//