ID Q708E5_HUMAN Unreviewed; 402 AA. AC Q708E5; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 12-OCT-2022, entry version 150. DE SubName: Full=C-myb v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS {ECO:0000313|EMBL:CAF04481.1}; DE SubName: Full=V-myb myeloblastosis viral oncogene homolog (Avian), isoform CRA_l {ECO:0000313|EMBL:EAW47978.1}; DE SubName: Full=V-myb myeloblastosis viral oncogene homologue (Avian) {ECO:0000313|EMBL:CAE55169.1}; GN Name=c-myb {ECO:0000313|EMBL:CAE55169.1}; GN Synonyms=MYB {ECO:0000313|EMBL:EAW47978.1}; GN ORFNames=hCG_32380 {ECO:0000313|EMBL:EAW47978.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAF04481.1}; RN [1] {ECO:0000313|EMBL:EAW47978.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., RA Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H., RA Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., RA Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., RA McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., RA Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., RA Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., RA Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., RA Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., RA Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., RA Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., RA Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., RA Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., RA Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., RA Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., RA Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., RA Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., RA Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., RA Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., RA Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., RA Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., RA Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., RA McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., RA Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., RA Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., RA Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., RA Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., RA Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., RA Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., RA Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., RA Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., RA Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., RA Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., RA Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., RA Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., RA Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., RA Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|EMBL:CAF04481.1} RP NUCLEOTIDE SEQUENCE. RA Close J.P., Game L., Clark B., Berginoux J., Gerovassili A., Thein S.; RT "Genome annotation and mutation analysis of a 1.5Mb region of 6q23 RT encompassing a Quantitative Trait Locus for foetal haemoglobin RT expression."; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:CAE55169.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15169551; DOI=10.1186/1471-2164-5-33; RA Close J.P., Game L., Clark B., Bergounioux J., Gerovassili A., Thein S.L.; RT "Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing RT a quantitative trait locus for fetal hemoglobin expression in adults."; RL BMC Genomics 5:33-33(2004). RN [4] {ECO:0000313|EMBL:EAW47978.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ606318; CAE55169.1; -; mRNA. DR EMBL; AJ616791; CAF04481.1; -; mRNA. DR EMBL; AJ616792; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616793; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616794; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616795; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616796; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616797; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616798; CAF04481.1; JOINED; mRNA. DR EMBL; AJ616799; CAF04481.1; JOINED; mRNA. DR EMBL; CH471051; EAW47978.1; -; Genomic_DNA. DR SMR; Q708E5; -. DR MaxQB; Q708E5; -. DR PRIDE; Q708E5; -. DR UCSC; uc063rpo.1; human. DR VEuPathDB; HostDB:ENSG00000118513; -. DR ChiTaRS; MYB; human. DR ExpressionAtlas; Q708E5; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd00167; SANT; 3. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017930; Myb_dom. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR012642; Tscrpt_reg_Wos2-domain. DR Pfam; PF07988; LMSTEN; 1. DR Pfam; PF00249; Myb_DNA-binding; 3. DR SMART; SM00717; SANT; 3. DR SUPFAM; SSF46689; SSF46689; 2. DR PROSITE; PS51294; HTH_MYB; 3. DR PROSITE; PS50090; MYB_LIKE; 3. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}. FT DOMAIN 35..86 FT /note="HTH myb-type" FT /evidence="ECO:0000259|PROSITE:PS51294" FT DOMAIN 35..86 FT /note="Myb-like" FT /evidence="ECO:0000259|PROSITE:PS50090" FT DOMAIN 87..142 FT /note="HTH myb-type" FT /evidence="ECO:0000259|PROSITE:PS51294" FT DOMAIN 87..138 FT /note="Myb-like" FT /evidence="ECO:0000259|PROSITE:PS50090" FT DOMAIN 139..189 FT /note="Myb-like" FT /evidence="ECO:0000259|PROSITE:PS50090" FT DOMAIN 143..193 FT /note="HTH myb-type" FT /evidence="ECO:0000259|PROSITE:PS51294" FT REGION 335..368 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 402 AA; 46065 MW; 331FC406EC1C335C CRC64; MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE HHSTPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SM //