ID Q701L7_HUMAN Unreviewed; 513 AA. AC Q701L7; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 09-DEC-2015, entry version 61. DE SubName: Full=Type II hair keratin 2 {ECO:0000313|EMBL:CAF31523.1}; GN Name=KRTHB2 {ECO:0000313|EMBL:CAF31523.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAF31523.1}; RN [1] {ECO:0000313|EMBL:CAF31523.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Human scalp {ECO:0000313|EMBL:CAF31523.1}; RX PubMed=10692104; DOI=10.1046/j.1523-1747.2000.00910.x; RA Rogers M.A., Winter H., Langbein L., Wolf C., Schweizer J.; RT "Characterization of a 300 kbp region of human DNA containing the type RT II hair keratin."; RL J. Invest. Dermatol. 114:464-472(2000). RN [2] {ECO:0000313|EMBL:CAF31523.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Human scalp {ECO:0000313|EMBL:CAF31523.1}; RX PubMed=15737194; DOI=10.1111/j.0022-202X.2004.23530.x; RA Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., RA Schweizer J.; RT "Characterization of new members of the human type II keratin gene RT family and a general evaluation of the keratin gene domain on RT chromosome 12q13.13."; RL J. Invest. Dermatol. 124:536-544(2005). CC -!- SIMILARITY: Belongs to the intermediate filament family. CC {ECO:0000256|RuleBase:RU000685}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ628419; CAF31523.1; -; mRNA. DR UniGene; Hs.134640; -. DR ProteinModelPortal; Q701L7; -. DR STRING; 9606.ENSP00000257974; -. DR PaxDb; Q701L7; -. DR PRIDE; Q701L7; -. DR H-InvDB; HIX0036743; -. DR eggNOG; ENOG410IG4R; Eukaryota. DR eggNOG; ENOG410YY6B; LUCA. DR HOVERGEN; HBG013015; -. DR GO; GO:0045095; C:keratin filament; IEA:InterPro. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR InterPro; IPR001664; IF. DR InterPro; IPR018039; Intermediate_filament_CS. DR InterPro; IPR032444; Keratin_2_head. DR InterPro; IPR003054; Keratin_II. DR PANTHER; PTHR23239; PTHR23239; 1. DR Pfam; PF00038; Filament; 1. DR Pfam; PF16208; Keratin_2_head; 1. DR PRINTS; PR01276; TYPE2KERATIN. DR PROSITE; PS00226; IF; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAAS:SAAS00031873, ECO:0000256|SAM:Coils}; KW Intermediate filament {ECO:0000256|RuleBase:RU000685, KW ECO:0000256|SAAS:SAAS00031864}; KW Keratin {ECO:0000313|EMBL:CAF31523.1}. FT DOMAIN 62 116 Keratin_2_head. {ECO:0000259|Pfam: FT PF16208}. FT COILED 124 144 {ECO:0000256|SAM:Coils}. FT COILED 236 256 {ECO:0000256|SAM:Coils}. FT COILED 329 366 {ECO:0000256|SAM:Coils}. FT COILED 375 409 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 513 AA; 56649 MW; C0552BA5B7110BB8 CRC64; MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPILE GYISALRRQL DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSMPV LSTGVLRSNG GCSIVGTGEL YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH //