ID Q6ZY54_KLEPN Unreviewed; 263 AA. AC Q6ZY54; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 01-OCT-2014, entry version 40. DE RecName: Full=Beta-lactamase {ECO:0000256|RuleBase:RU361140}; DE EC=3.5.2.6 {ECO:0000256|RuleBase:RU361140}; DE Flags: Fragment {ECO:0000313|EMBL:CAG25835.1}; GN Name=blaLEN {ECO:0000313|EMBL:CAG25835.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:CAG25835.1}; RN [1] {ECO:0000313|EMBL:CAG25835.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=UD827:1 {ECO:0000313|EMBL:CAG25835.1}; RX PubMed=15215087; DOI=10.1128/AAC.48.7.2400-2408.2004; RA Haeggman S., Loefdahl S., Paauw A., Verhoef J., Brisse S.; RT "Diversity and evolution of the class A chromosomal beta-lactamase RT gene in Klebsiella pneumoniae."; RL Antimicrob. Agents Chemother. 48:2400-2408(2004). CC -!- CATALYTIC ACTIVITY: A beta-lactam + H(2)O = a substituted beta- CC amino acid. {ECO:0000256|RuleBase:RU361140, CC ECO:0000256|SAAS:SAAS00062125}. CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family. CC {ECO:0000256|RuleBase:RU361140}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ635424; CAG25835.1; -; Genomic_DNA. DR ProteinModelPortal; Q6ZY54; -. DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro. DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro. DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. DR Gene3D; 3.40.710.10; -; 1. DR InterPro; IPR012338; Beta-lactam/transpept-like. DR InterPro; IPR000871; Beta-lactam_class-A/D. DR InterPro; IPR023650; Beta-lactam_class-A_AS. DR PRINTS; PR00118; BLACTAMASEA. DR SUPFAM; SSF56601; SSF56601; 1. DR PROSITE; PS00146; BETA_LACTAMASE_A; 1. PE 3: Inferred from homology; KW Antibiotic resistance {ECO:0000256|RuleBase:RU361140, KW ECO:0000256|SAAS:SAAS00129359}; KW Hydrolase {ECO:0000256|RuleBase:RU361140, KW ECO:0000256|SAAS:SAAS00011649}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAG25835.1}. FT NON_TER 263 263 {ECO:0000313|EMBL:CAG25835.1}. SQ SEQUENCE 263 AA; 28331 MW; 7A71E3F2267930B8 CRC64; ATLPLVVYAG PQPLEQIKQS ESQLPGRVGM VEMDLASGRT LAAWRADERF PMVSTFKVLL CGAVLARVDA GLEQLDRRIH YRQQDLVDYS PVSEKHLVDG MTIGELCAAA ITLSDNSAGN LLLATVGGPA GLTAFLRQIG DNVTHLDRWE TALNEALPGD ARDTTTPASM AATLRKLLTA QHLSARSQQQ LLQWMVDDRV AGPLIRAVLP PGWFIADKTG AGERGARGIV ALLGPDGKPE RIVVIYLRDT PASMAERNQH IAG //