ID Q6ZWL1_HUMAN Unreviewed; 279 AA. AC Q6ZWL1; A6NCM2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 13-NOV-2013, entry version 63. DE SubName: Full=cDNA FLJ16017 fis, clone TESTI2002618, weakly similar to ADAM 2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis; RA Suzuki O., Sasaki N., Aotsuka S., Shoji T., Ichihara T., Shiohata N., RA Matsumoto K., Hirano M., Sano S., Nomura R., Yoshikawa Y., RA Matsumura Y., Moriya S., Chiba E., Momiyama H., Onogawa S., RA Kaeriyama S., Satoh N., Matsunawa H., Takahashi E., Kataoka R., RA Kuga N., Kuroda A., Satoh I., Kamata K., Takami S., Terashima Y., RA Watanabe M., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., RA Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., RA Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., RA Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., RA Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y., RA Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC -!- SIMILARITY: Contains 1 peptidase M12B domain. CC -!- SIMILARITY: Contains peptidase M12B domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK122608; BAC85489.1; -; mRNA. DR IPI; IPI00446857; -. DR UniGene; Hs.521545; -. DR ProteinModelPortal; Q6ZWL1; -. DR SMR; Q6ZWL1; 184-275. DR PRIDE; Q6ZWL1; -. DR HOGENOM; HOG000230883; -. DR HOVERGEN; HBG065758; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR Gene3D; 3.40.390.10; -; 1. DR InterPro; IPR024079; MetalloPept_cat_dom. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF01421; Reprolysin; 1. DR PROSITE; PS50215; ADAM_MEPRO; 1. PE 2: Evidence at transcript level; KW Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Protease; KW Secreted. SQ SEQUENCE 279 AA; 32092 MW; 02630EBBB7153321 CRC64; MFRLWLLLAG LCGLLASRPG FQNSLLQIVI PEKIQTNTND SSEIEYEQIS YIIPIDEKLY TVHLKQRYFL ADNFMIYLYN QGSMNTYSSD IQTQCYYQGN IEGYPDSMVT LSTCSGLRGI LQFENVSYGI EPLESAVEFQ HVLYKLKNED NDIAIFIDRS LKEQPMDDNI FISEKSEPAV PDLFPLYLEM HIVVDKTLYD YWGSDSMIVT NKVIEIVGLA NSMFTQFKVT IVLSSLELWS DENKISTVGE ADWREMKSVI VVLRLNVDLQ AVVIFELVY //