ID   UBR3_HUMAN              Reviewed;        1888 AA.
AC   Q6ZT12; B4DZR7; Q2KHN5; Q6ZR55; Q6ZSC2; Q8IVE7; Q8ND96;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   10-FEB-2021, entry version 151.
DE   RecName: Full=E3 ubiquitin-protein ligase UBR3;
DE            EC=2.3.2.27;
DE   AltName: Full=N-recognin-3;
DE   AltName: Full=RING-type E3 ubiquitin transferase UBR3;
DE   AltName: Full=Ubiquitin-protein ligase E3-alpha-3;
DE   AltName: Full=Ubiquitin-protein ligase E3-alpha-III;
DE   AltName: Full=Zinc finger protein 650;
GN   Name=UBR3; Synonyms=KIAA2024, ZNF650;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Brain;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "The nucleotide sequence of a long cDNA clone isolated from human.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1092-1888 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [LARGE
RP   SCALE MRNA] OF 1330-1888 (ISOFORM 4).
RC   TISSUE=Brain, Testis, Tongue, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1432-1888 (ISOFORMS 1/2).
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   FUNCTION.
RX   PubMed=27331610; DOI=10.7554/elife.15258;
RA   Li T., Giagtzoglou N., Eberl D.F., Jaiswal S.N., Cai T., Godt D.,
RA   Groves A.K., Bellen H.J.;
RT   "The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in
RT   the auditory organs of Drosophila and mammals.";
RL   Elife 5:E15258-E15258(2016).
CC   -!- FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end
CC       rule pathway (By similarity). Does not bind to proteins bearing
CC       specific N-terminal residues that are destabilizing according to the N-
CC       end rule, leading to their ubiquitination and subsequent degradation
CC       (By similarity). May play a role in Shh signaling by mediating the
CC       ubiquitination of Kif7 (By similarity). May be important for MYH9
CC       function in certain tissues, possibly by regulating the ubiquitination
CC       of MYH9 and consequently affecting its interaction with MYO7A
CC       (PubMed:27331610). {ECO:0000250|UniProtKB:Q5U430,
CC       ECO:0000269|PubMed:27331610}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with UBE2A and UBE2B.
CC       {ECO:0000250|UniProtKB:Q5U430}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q6ZT12-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZT12-2; Sequence=VSP_030354, VSP_023142;
CC       Name=3;
CC         IsoId=Q6ZT12-3; Sequence=VSP_023141;
CC       Name=4;
CC         IsoId=Q6ZT12-4; Sequence=VSP_036405;
CC   -!- SIMILARITY: Belongs to the UBR1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC23120.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC86783.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC87032.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAG64179.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD38857.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB095944; BAC23120.1; ALT_INIT; mRNA.
DR   EMBL; AK126998; BAC86783.1; ALT_INIT; mRNA.
DR   EMBL; AK127553; BAC87032.1; ALT_INIT; mRNA.
DR   EMBL; AK128490; BAC87462.1; -; mRNA.
DR   EMBL; AK303062; BAG64179.1; ALT_INIT; mRNA.
DR   EMBL; AC009967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092641; AAY14890.1; -; Genomic_DNA.
DR   EMBL; AL834144; CAD38857.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS2238.2; -. [Q6ZT12-1]
DR   RefSeq; NP_742067.3; NM_172070.3. [Q6ZT12-1]
DR   SMR; Q6ZT12; -.
DR   BioGRID; 126237; 55.
DR   IntAct; Q6ZT12; 31.
DR   STRING; 9606.ENSP00000396068; -.
DR   iPTMnet; Q6ZT12; -.
DR   PhosphoSitePlus; Q6ZT12; -.
DR   BioMuta; UBR3; -.
DR   DMDM; 166214992; -.
DR   EPD; Q6ZT12; -.
DR   jPOST; Q6ZT12; -.
DR   MassIVE; Q6ZT12; -.
DR   MaxQB; Q6ZT12; -.
DR   PaxDb; Q6ZT12; -.
DR   PeptideAtlas; Q6ZT12; -.
DR   PRIDE; Q6ZT12; -.
DR   ProteomicsDB; 68252; -. [Q6ZT12-1]
DR   ProteomicsDB; 68253; -. [Q6ZT12-2]
DR   ProteomicsDB; 68254; -. [Q6ZT12-3]
DR   ProteomicsDB; 68255; -. [Q6ZT12-4]
DR   Antibodypedia; 33822; 39 antibodies.
DR   Ensembl; ENST00000272793; ENSP00000272793; ENSG00000144357. [Q6ZT12-1]
DR   Ensembl; ENST00000418381; ENSP00000396068; ENSG00000144357. [Q6ZT12-1]
DR   GeneID; 130507; -.
DR   KEGG; hsa:130507; -.
DR   UCSC; uc010zdi.3; human. [Q6ZT12-1]
DR   CTD; 130507; -.
DR   DisGeNET; 130507; -.
DR   GeneCards; UBR3; -.
DR   HGNC; HGNC:30467; UBR3.
DR   HPA; ENSG00000144357; Tissue enhanced (skeletal).
DR   MIM; 613831; gene.
DR   neXtProt; NX_Q6ZT12; -.
DR   OpenTargets; ENSG00000144357; -.
DR   PharmGKB; PA162407919; -.
DR   VEuPathDB; HostDB:ENSG00000144357.16; -.
DR   eggNOG; KOG1139; Eukaryota.
DR   GeneTree; ENSGT00950000183075; -.
DR   HOGENOM; CLU_000651_2_1_1; -.
DR   InParanoid; Q6ZT12; -.
DR   OMA; TLTDFEC; -.
DR   OrthoDB; 81415at2759; -.
DR   PhylomeDB; Q6ZT12; -.
DR   TreeFam; TF323875; -.
DR   PathwayCommons; Q6ZT12; -.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 130507; 6 hits in 877 CRISPR screens.
DR   ChiTaRS; UBR3; human.
DR   GenomeRNAi; 130507; -.
DR   Pharos; Q6ZT12; Tbio.
DR   PRO; PR:Q6ZT12; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q6ZT12; protein.
DR   Bgee; ENSG00000144357; Expressed in biceps brachii and 222 other tissues.
DR   ExpressionAtlas; Q6ZT12; baseline and differential.
DR   Genevisible; Q6ZT12; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0042048; P:olfactory behavior; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; ISS:UniProtKB.
DR   GO; GO:0001967; P:suckling behavior; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IBA:GO_Central.
DR   InterPro; IPR044046; E3_ligase_UBR-like_C.
DR   InterPro; IPR039164; UBR1-like.
DR   InterPro; IPR003126; Znf_UBR.
DR   PANTHER; PTHR21497; PTHR21497; 1.
DR   Pfam; PF18995; PRT6_C; 1.
DR   Pfam; PF02207; zf-UBR; 1.
DR   SMART; SM00396; ZnF_UBR1; 1.
DR   PROSITE; PS51157; ZF_UBR; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Membrane; Metal-binding; Phosphoprotein;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   CHAIN           1..1888
FT                   /note="E3 ubiquitin-protein ligase UBR3"
FT                   /id="PRO_0000278184"
FT   TRANSMEM        761..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        919..939
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1806..1826
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         118..189
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00508"
FT   ZN_FING         1306..1364
FT                   /note="RING-type; degenerate"
FT   COILED          1168..1199
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        2..118
FT                   /note="Ala-rich"
FT   COMPBIAS        1766..1808
FT                   /note="Cys-rich"
FT   MOD_RES         343
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5U430"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5U430"
FT   MOD_RES         1199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5U430"
FT   VAR_SEQ         1..1494
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_023141"
FT   VAR_SEQ         1..1179
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_030354"
FT   VAR_SEQ         1180..1211
FT                   /note="EERRQKARERQQKLLAEFASRQKSFMETAMDV -> MIASKQRQFTEVFRIM
FT                   SSTFSQSRFLYAAVVT (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_023142"
FT   VAR_SEQ         1485
FT                   /note="N -> NFCFIISPFTKSEIILCQYRKSHDKVYPKY (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_036405"
FT   CONFLICT        1791
FT                   /note="L -> F (in Ref. 2; BAC87032)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1888 AA;  212433 MW;  5F5525B33D2E9153 CRC64;
     MAAAAAAAVG GQQPSQPELP APGLALDKAA TAAHLKAALS RPDNRAGAEE LQALLERVLS
     AERPLAAAAG GEDAAAAGGG GGPGAAEEEA LEWCKCLLAG GGGYDEFCAA VRAYDPAALC
     GLVWTANFVA YRCRTCGISP CMSLCAECFH QGDHTGHDFN MFRSQAGGAC DCGDSNVMRE
     SGFCKRHQIK SSSNIPCVPK DLLMMSEFVL PRFIFCLIQY LREGYNEPAA DGPSEKDLNK
     VLQLLEPQIS FLEDLTKMGG AMRSVLTQVL TNQQNYKDLT SGLGENACVK KSHEKYLIAL
     KSSGLTYPED KLVYGVQEPS AGTSSLAVQG FIGATGTLGQ VDSSDEDDQD GSQGLGKRKR
     VKLSSGTKDQ SIMDVLKHKS FLEELLFWTI KYEFPQKMVT FLLNMLPDQE YKVAFTKTFV
     QHYAFIMKTL KKSHESDTMS NRIVHISVQL FSNEELARQV TEECQLLDIM VTVLLYMMES
     CLIKSELQDE ENSLHVVVNC GEALLKNNTY WPLVSDFINI LSHQSVAKRF LEDHGLLVTW
     MNFVSFFQGM NLNKRELNEH VEFESQTYYA AFAAELEACA QPMWGLLSHC KVRETQEYTR
     NVVRYCLEAL QDWFDAINFV DEPAPNQVTF HLPLHRYYAM FLSKAVKCQE LDLDSVLPDQ
     EMLMKLMIHP LQIQASLAEI HSNMWVRNGL QIKGQAMTYV QSHFCNSMID PDIYLLQVCA
     SRLDPDYFIS SVFERFKVVD LLTMASQHQN TVLDAEHERS MLEGALTFLV ILLSLRLHLG
     MSDDEILRAE MVAQLCMNDR THSSLLDLIP ENPNPKSGII PGSYSFESVL SAVADFKAPV
     FEPGGSMQQG MYTPKAEVWD QEFDPVMVIL RTVYRRDVQS AMDRYTAFLK QSGKFPGNPW
     PPYKKRTSLH PSYKGLMRLL HCKTLHIVLF TLLYKILMDH QNLSEHVLCM VLYLIELGLE
     NSAEEESDEE ASVGGPERCH DSWFPGSNLV SNMRHFINYV RVRVPETAPE VKRDSPASTS
     SDNLGSLQNS GTAQVFSLVA ERRKKFQEII NRSSSEANQV VRPKTSSKWS APGSAPQLTT
     AILEIKESIL SLLIKLHHKL SGKQNSYYPP WLDDIEILIQ PEIPKYSHGD GITAVERILL
     KAASQSRMNK RIIEEICRKV TPPVPPKKVT AAEKKTLDKE ERRQKARERQ QKLLAEFASR
     QKSFMETAMD VDSPENDIPM EITTAEPQVS EAVYDCVICG QSGPSSEDRP TGLVVLLQAS
     SVLGQCRDNV EPKKLPISEE EQIYPWDTCA AVHDVRLSLL QRYFKDSSCL LAVSIGWEGG
     VYVQTCGHTL HIDCHKSYME SLRNDQVLQG FSVDKGEFTC PLCRQFANSV LPCYPGSNVE
     NNPWQRPSNK SIQDLIKEVE ELQGRPGAFP SETNLSKEME SVMKDIKNTT QKKYRDYSKT
     PGSPDNDFLF MYSVARTNLE LELIHRGGNL CSGGASTAGK RSCLNQLFHV LALHMRLYSI
     DSEYNPWRKL TQLEEMNPQL GYEEQQPEVP ILYHDVTSLL LIQILMMPQP LRKDHFTCIV
     KVLFTLLYTQ ALAALSVKCS EEDRSAWKHA GALKKSTCDA EKSYEVLLSF VISELFKGKL
     YHEEGTQECA MVNPIAWSPE SMEKCLQDFC LPFLRITSLL QHHLFGEDLP SCQEEEEFSV
     LASCLGLLPT FYQTEHPFIS ASCLDWPVPA FDIITQWCFE IKSFTERHAE QGKALLIQES
     KWKLPHLLQL PENYNTIFQY YHRKTCSVCT KVPKDPAVCL VCGTFVCLKG LCCKQQSYCE
     CVLHSQNCGA GTGIFLLINA SVIIIIRGHR FCLWGSVYLD AHGEEDRDLR RGKPLYICKE
     RYKVLEQQWI SHTFDHINKR WGPHYNGL
//