ID   CA122_HUMAN             Reviewed;         110 AA.
AC   Q6ZSJ8; A2RQF4; E9PQ13; Q56A71;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   22-APR-2020, entry version 106.
DE   RecName: Full=Uncharacterized protein C1orf122;
DE   AltName: Full=Protein ALAESM;
GN   Name=C1orf122;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Subthalamic nucleus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Chen S., Guo J.H., Yu L.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZSJ8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZSJ8-2; Sequence=VSP_046648;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH57819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=BAC86950.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR   EMBL; AK127381; BAC86950.1; ALT_SEQ; mRNA.
DR   EMBL; AY517499; AAS76640.1; -; mRNA.
DR   EMBL; AL929472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057819; AAH57819.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS427.2; -. [Q6ZSJ8-1]
DR   CCDS; CCDS44112.1; -. [Q6ZSJ8-2]
DR   RefSeq; NP_001136198.1; NM_001142726.1. [Q6ZSJ8-2]
DR   RefSeq; NP_940848.2; NM_198446.2. [Q6ZSJ8-1]
DR   SMR; Q6ZSJ8; -.
DR   BioGrid; 126077; 11.
DR   IntAct; Q6ZSJ8; 10.
DR   STRING; 9606.ENSP00000362133; -.
DR   iPTMnet; Q6ZSJ8; -.
DR   PhosphoSitePlus; Q6ZSJ8; -.
DR   BioMuta; C1orf122; -.
DR   EPD; Q6ZSJ8; -.
DR   jPOST; Q6ZSJ8; -.
DR   MassIVE; Q6ZSJ8; -.
DR   MaxQB; Q6ZSJ8; -.
DR   PaxDb; Q6ZSJ8; -.
DR   PeptideAtlas; Q6ZSJ8; -.
DR   PRIDE; Q6ZSJ8; -.
DR   ProteomicsDB; 22883; -.
DR   ProteomicsDB; 68221; -. [Q6ZSJ8-1]
DR   TopDownProteomics; Q6ZSJ8-1; -. [Q6ZSJ8-1]
DR   Antibodypedia; 54370; 51 antibodies.
DR   Ensembl; ENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
DR   Ensembl; ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
DR   Ensembl; ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
DR   GeneID; 127687; -.
DR   KEGG; hsa:127687; -.
DR   UCSC; uc001ccd.3; human. [Q6ZSJ8-1]
DR   CTD; 127687; -.
DR   GeneCards; C1orf122; -.
DR   HGNC; HGNC:24789; C1orf122.
DR   HPA; ENSG00000197982; Low tissue specificity.
DR   neXtProt; NX_Q6ZSJ8; -.
DR   OpenTargets; ENSG00000197982; -.
DR   PharmGKB; PA142672440; -.
DR   eggNOG; ENOG410JCWU; Eukaryota.
DR   eggNOG; ENOG41117TV; LUCA.
DR   GeneTree; ENSGT00570000079623; -.
DR   HOGENOM; CLU_3175232_0_0_1; -.
DR   InParanoid; Q6ZSJ8; -.
DR   OMA; AREARPH; -.
DR   OrthoDB; 1560404at2759; -.
DR   ChiTaRS; C1orf122; human.
DR   GenomeRNAi; 127687; -.
DR   Pharos; Q6ZSJ8; Tdark.
DR   PRO; PR:Q6ZSJ8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q6ZSJ8; protein.
DR   Bgee; ENSG00000197982; Expressed in substantia nigra and 203 other tissues.
DR   Genevisible; Q6ZSJ8; HS.
DR   InterPro; IPR031714; DUF4726.
DR   PANTHER; PTHR41401; PTHR41401; 1.
DR   Pfam; PF15855; DUF4726; 1.
PE   4: Predicted;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..110
FT                   /note="Uncharacterized protein C1orf122"
FT                   /id="PRO_0000254193"
FT   COILED          36..68
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..63
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_046648"
SQ   SEQUENCE   110 AA;  11471 MW;  C63352FB57850CFE CRC64;
     MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR QRQLLDTIAA
     CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP KDAGDGAAEP
//